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    pdm3 pou domain motif 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdm3provided by FlyBase
    Official Full Name
    pou domain motif 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0261588
    Locus tag
    Dmel_CG42698
    See related
    AllianceGenome:FB:FBgn0261588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT16994; CG11641; CG14755; CG42698; Dmel\CG42698; Pdm3
    Old locus tag
    Dmel_CG11641; Dmel_CG14755
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in axon guidance; axon target recognition; and sensory perception of smell. Is expressed in several structures, including adult brain cell body rind; adult pars intercerebralis; appendage; chemosensory neurons; and ellipsoid body. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human POU6F1 (POU class 6 homeobox 1) and POU6F2 (POU class 6 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pdm3 in Genome Data Viewer
    Location:
    44C4-44C4; 2-58 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8327490..8396280)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4214995..4283785)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44450 Neighboring gene long noncoding RNA: testis-specific 18 Neighboring gene uncharacterized protein Neighboring gene hug-bell Neighboring gene spacewatch Neighboring gene whipple Neighboring gene uncharacterized protein Neighboring gene comas sola Neighboring gene swift-tuttle Neighboring gene borrelly Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The pdm3 Locus Is a Hotspot for Recurrent Evolution of Female-Limited Color Dimorphism in Drosophila. Yassin A, et al. Curr Biol, 2016 Sep 26. PMID 27546577, Free PMC Article
    2. Evolution of assortative mating following selective introgression of pigmentation genes between two Drosophila species. David JR, et al. Ecol Evol, 2022 Apr. PMID 35432924, Free PMC Article
    3. Evo-devo applied to sleep research: an approach whose time has come. Brown RE. Sleep Adv, 2024. PMID 39022590, Free PMC Article
    4. Thermodynamic model of gene regulation for the Or59b olfactory receptor in Drosophila. González A, et al. PLoS Comput Biol, 2019 Jan. PMID 30653495, Free PMC Article
    5. Olfactory receptor-dependent receptor repression in Drosophila. Mika K, et al. Sci Adv, 2021 Aug. PMID 34362730, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of a molecular basis for the juvenile sleep state.
      Title: Identification of a molecular basis for the juvenile sleep state.
    2. POU domain motif3 (Pdm3) induces wingless (wg) transcription and is essential for development of larval neuromuscular junctions in Drosophila.
      Title: POU domain motif3 (Pdm3) induces wingless (wg) transcription and is essential for development of larval neuromuscular junctions in Drosophila.
    3. Our results...establish Pdm3 as a regulator of interoceptive axon targeting.
      Title: Diversity of Internal Sensory Neuron Axon Projection Patterns Is Controlled by the POU-Domain Protein Pdm3 in Drosophila Larvae.
    4. POU domain motif 3 (Pdm3) is required in ring (R) neurons to control precise axon targeting to the Drosophila ellipsoid body (EB).
      Title: The POU-domain protein Pdm3 regulates axonal targeting of R neurons in the Drosophila ellipsoid body.
    5. This study demonstrates a role for pdm3 in both of the processes that define the functional organization of ORNs in the olfactory system.
      Title: A new Drosophila POU gene, pdm3, acts in odor receptor expression and axon targeting of olfactory neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 8330917-8331345 mobile_element_type = transposon:roo{}775
    • Loc: 8366822-8367021 mobile_element_type = transposon:INE-1{}3539
    • Loc: 8370590-8370783 mobile_element_type = transposon:INE-1{}3540

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pou domain motif 3
    Names
    CG42698-PA
    CG42698-PC
    CG42698-PE
    CG42698-PF
    POU domain motif 3
    pdm3-PA
    pdm3-PC
    pdm3-PE
    pdm3-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8327490..8396280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201956.2 → NP_001188885.2  pou domain motif 3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188885.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD55
      Conserved Domains (2) summary
      pfam00046
      Location:1228 → 1281
      Homeobox; Homeobox domain
      cl22952
      Location:1108 → 1200
      Pou; Pou domain - N-terminal to homeobox domain

    2. NM_001144145.4 → NP_001137617.2  pou domain motif 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137617.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZU0
      Conserved Domains (2) summary
      pfam00046
      Location:1227 → 1280
      Homeobox; Homeobox domain
      cl22952
      Location:1108 → 1199
      Pou; Pou domain - N-terminal to homeobox domain

    3. NM_001299264.1 → NP_001286193.1  pou domain motif 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286193.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEG2
      Conserved Domains (2) summary
      pfam00046
      Location:1209 → 1262
      Homeobox; Homeobox domain
      cl22952
      Location:1108 → 1181
      Pou; Pou domain - N-terminal to homeobox domain

    4. NM_136533.2 → NP_610377.1  pou domain motif 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUR9
      Related
      FBpp0292044
      Conserved Domains (2) summary
      pfam00046
      Location:930 → 983
      Homeobox; Homeobox domain
      cl22952
      Location:811 → 902
      Pou; Pou domain - N-terminal to homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD55 A0A0B4JD55
    A0A0B4LEG2 A0A0B4LEG2
    B7YZU0 B7YZU0
    Q7JUR9 Q7JUR9

    Gene LinkOut

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