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| Status |
Public on Oct 19, 2017 |
| Title |
Expression data from mouse tissue Angiotensin II treated for 0, 1, 3, 7 days |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Angiotensin II (Ang II) mediated signaling plays a key role in the development of hypertension associated target organ damages. However, the gene expression changes regulated by Ang II in the early stage of acute cerebral, cardiac, renal, vascular injury remain unclear.
we investigated Ang II–mediated gene expression alteration associated with the development of early cerebral, cardiac, renal, vascular injury by microarray assay in a mouse model.
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| Overall design |
All mice were euthanized by an overdose of pentobarbital on days 1, 3 and 7 of Angiotensin II treatment. Total RNA was isolated with TRIzol (Invitrogen) fromvessels (n=3 per group) at each time point according to manufacturer’s instructions. Gene expression profiling was performed using Affymetrix GeneChip mouse Genome 430 2.0 array according to the manufacturer’s instructions (Affymetrix, Inc., Santa Clara, CA). On the GeneChip Mouse Genome 430 2.0 Array, over 45,000 probe sets analyze the expression level of over 39,000 transcripts and variants from over 34,000 well characterized mouse genes.
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| Contributor(s) |
Li H, Zhang Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Oct 18, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
李 玉琳 |
| Organization name |
Beijing Institute of Heart Lung and Blood Vessel Diseases
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| Street address |
2 Anzhen Rd, Chaoyang District,
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| City |
Beijing |
| ZIP/Postal code |
100029 |
| Country |
China |
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| Platforms (1) |
| GPL20775 |
[MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CSV version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA414714 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE105114_RAW.tar |
256.8 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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