|
| Status |
Public on Nov 13, 2010 |
| Title |
Effect of PDE4 inhibition on host gene expression of Mtb-infected mouse lungs. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Global gene expressions of Mtb-infected mouse lungs were compared between with and without PDE4 inhibitor treatment. A lot of host genes are differentially expressed 21d and 28d post-Mtb infection. PDE4 inhibitor, however, downregulate 10% of genes among those and genes differentially regulated by PDE4 inhibitor are mainly involved immune response.
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| |
|
| Overall design |
Total RNA was isolated from Mtb-infected mouse lungs with or without CC-3052 (25 mg/kg/day) using Trizol reagent and gene profile was analyed using Affymetrix mouse ST 1.0
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| |
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| Contributor(s) |
Koo M, Guo H, Kaplan G |
| Citation(s) |
21364878 |
| |
| Submission date |
Nov 12, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Mi-Sun Koo |
| E-mail(s) |
[email protected]
|
| Phone |
9738543226
|
| Fax |
972854322
|
| Organization name |
University of Medicine and Dentistry of New Jersey
|
| Department |
Public Health Research Institute
|
| Street address |
225 Warren Street, W250Q
|
| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07103 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (47)
|
|
| Relations |
| BioProject |
PRJNA134885 |
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