|
| Status |
Public on Dec 01, 2011 |
| Title |
Expression data from p27WT, p27CK and KO MEFs cells in quiescence |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Low levels of the cell cycle regulator p27Kip1 are associated with a worse outcome in many tumor types. We report here a new regulatory role of p27Kip1 as a transcriptional regulator. In association with transcriptional factors such as ETS and E2F4 and co-repressors like p130, HDACs and mSin3A, p27 binds to promoters of multiple genes leading to their repression. The p27-target genes participate in RNA processing, translation, respiration and cell cycle. Remarkably, p27-target genes are over-expressed in different human tumors in tight association with a poor clinical prognosis. We also observed a clear correlation between low levels of p27 and over-expression of p27-target genes in tumors. Overall, our findings indicate new tumor suppressor roles of p271 as a transcriptional regulator of genes relevant for oncogenesis.
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| Overall design |
Samples from MEFs p27WT, p27CK and p27KO cells were analyzed
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|
| Contributor(s) |
Pippa R, Espinosa L, Gundem G, García-Escudero R, Domínguez A, Sainz C, Besson A, Pujol MJ, López-Bigas N, Paramio JM, Bachs O |
| Citation(s) |
22179826 |
| |
| Submission date |
Mar 03, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
oriol bachs |
| E-mail(s) |
[email protected], [email protected]
|
| Phone |
636574156
|
| Fax |
0034-934021907
|
| Organization name |
University of Barcelona
|
| Department |
Cell Biology, Immunology and Neurosciences
|
| Street address |
Casanova 143
|
| City |
Barcelona |
| ZIP/Postal code |
08036 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE20069 |
p27Kip1 regulates transcription of genes involved in tumorigenesis |
|
| Relations |
| BioProject |
PRJNA138185 |
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