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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 15, 2011 |
| Title |
Expression data comparing the effect of IKK2 KO on a KRAS mouse model |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Given that the NF-κB pathway plays an important role in tumor development and that IKK2 is the seminal kinase responsible for NF-κB pathway activation, we were particularly interested in exploring the therapeutic potential of IKK2 inhibition in non-small cell lung cancers.
We crossed IKK2fl/fl and KrasG12D mice so that we could simultaneously activate KrasG12D to initiate tumor formation and inactivate IKK2, upon transduction by Cre lentiviral vectors.
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| Overall design |
RNA isolated from finely dissected tumor nodules and tumor cell lines (4A3 and1D3) was applied to microarray analysis using Affymetrix Mouse Gene 1.0 STArrays according to the manufacturer’s instructions.
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| Contributor(s) |
Xia Y, Yeddula N, Ke E, Verma I |
| Citation(s) |
22327365 |
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| Submission date |
Jun 17, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Eugene Ke |
| Organization name |
University of Virginia
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| Department |
MIC
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| Street address |
P.O. Box 800734, 1340 Jefferson Park Avenue
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| City |
Charlottesville |
| State/province |
Virginia |
| ZIP/Postal code |
22903 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| GSM743883 |
IKK2 WT cell line, biological replicate 1 |
| GSM743884 |
IKK2 WT cell line, biological replicate 2 |
| GSM743885 |
IKK2 -/- cell line, biological replicate 1 |
| GSM743886 |
IKK2 -/- cell line, biological replicate 2 |
| GSM743887 |
IKK2 WT tumor, biological replicate 1 |
| GSM743888 |
IKK2 WT tumor, biological replicate 2 |
| GSM743889 |
IKK2 WT tumor, biological replicate 3 |
| GSM743890 |
IKK2 WT tumor, biological replicate 4 |
| GSM743891 |
IKK2 -/- tumor, biological replicate 1 |
| GSM743892 |
IKK2 -/- tumor, biological replicate 2 |
| GSM743893 |
IKK2 -/- tumor, biological replicate 3 |
| GSM743894 |
IKK2 -/- tumor, biological replicate 4 |
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| Relations |
| BioProject |
PRJNA144073 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30049_RAW.tar |
54.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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