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| Status |
Public on Jul 03, 2014 |
| Title |
Gene expression profile of human cardiac fibroblasts (HCFs), induced cardiomyocytes (iCMs), and heart |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Global gene expression profile of total 24460 probes in the iCMs. The gene expression shifts from a fibroblast state toward a cardiac-like phenotype by Gata4/Mef2c/Tbx5/Mesp1/Myocd (GMTMM) or GMTMM/miR-133 transduction at 7 days after transduction.
MiR-133 silenced fibroblast signatures in parallel with cardiac gene activation, and Snai1 overexpression inhibited the effects of miR-133-mediated cardiac reprogramming.
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| Overall design |
HCFs were used for negative control, human heart tissue for positive control. Gene expression profiles were compared among HCFs, iCMs and heart. 24460 probes were analyzed in each experiment.
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| Contributor(s) |
Muraoka N, Ieda M |
| Citation(s) |
24920580 |
| |
| Submission date |
Apr 17, 2014 |
| Last update date |
Jul 03, 2014 |
| Contact name |
Satoshi Kondo |
| Organization name |
Toray Industries,Inc.
|
| Department |
New Projects Development Division
|
| Street address |
Tebiro 6-10-1
|
| City |
Kamakura |
| State/province |
Kanagawa |
| ZIP/Postal code |
248-8555 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL13915 |
3D-Gene Human Oligo chip 25k V2.1 |
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| Samples (5)
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| This SubSeries is part of SuperSeries: |
| GSE56913 |
Gene expression profiles of induced cardiomyocytes(iCMs) |
|
| Relations |
| BioProject |
PRJNA244923 |
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