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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 07, 2014 |
| Title |
Expression data from GNMT and MAT1A knockout models that develop all the stages of non-alcoholic fatty liver disease including hepatocellular carcinoma [MAT1A_15months] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Liver global gene expression patterns of 15-month-old MAT1A knockout mice histopathologically determined to have hepatocellular carcinoma (HCC). 5 samples are of tumoral tissue and 5 samples are of peritumoral tissue. All these have their respective wild type patterns. These were analyzed to define signatures to study the pathogenesis of NAFLD-derived HCC, explore which subtypes of cancers can be investigated using mouse models and define a signature of HCC differential survival that can be used to characterize HCC subtypes of different survival derived from mixed etiologies.
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| Overall design |
MAT1A-knockout mice liver tumoral and peritumoral tissue samples having hepatocellular carcinoma were selected for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Frades I |
| Citation(s) |
25993042 |
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| Submission date |
Nov 06, 2014 |
| Last update date |
May 04, 2018 |
| Contact name |
Itziar Frades |
| Organization name |
Swedish University of Agricultural Sciences
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| Department |
Plant Protection Biology
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| Street address |
Sundsvägen 14
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| City |
Alnarp |
| ZIP/Postal code |
SE-230 53 |
| Country |
Sweden |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (15)
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| GSM1539797 |
Wild type used for MAT1A 15 month, replicate 1 |
| GSM1539798 |
Wild type used for MAT1A 15 month, replicate 2 |
| GSM1539799 |
Wild type used for MAT1A 15 month, replicate 3 |
| GSM1539800 |
Wild type used for MAT1A 15 month, replicate 4 |
| GSM1539801 |
Wild type used for MAT1A 15 month, replicate 5 |
| GSM1539802 |
MAT1A knockout at 15 month age, peritumoral tissues, biological replicate 1 |
| GSM1539803 |
MAT1A knockout at 15 month age, peritumoral tissues, biological replicate 2 |
| GSM1539804 |
MAT1A knockout at 15 month age, peritumoral tissues, biological replicate 3 |
| GSM1539805 |
MAT1A knockout at 15 month age, peritumoral tissues, biological replicate 4 |
| GSM1539806 |
MAT1A knockout at 15 month age, peritumoral tissues, biological replicate 5 |
| GSM1539807 |
MAT1A knockout at 15 month age, tumoral tissue, biological replicate 1 |
| GSM1539808 |
MAT1A knockout at 15 month age, tumoral tissue, biological replicate 2 |
| GSM1539809 |
MAT1A knockout at 15 month age, tumoral tissue, biological replicate 3 |
| GSM1539810 |
MAT1A knockout at 15 month age, tumoral tissue, biological replicate 4 |
| GSM1539811 |
MAT1A knockout at 15 month age, tumoral tissue, biological replicate 5 |
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| This SubSeries is part of SuperSeries: |
| GSE63068 |
Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic fatty liver disease |
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| Relations |
| BioProject |
PRJNA266544 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE63062_KO_vs_WT_ratios.txt.gz |
1.2 Mb |
(ftp)(http) |
TXT |
| GSE63062_RAW.tar |
29.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
| Processed data are available on Series record |
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