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Adenosquamous carcinoma

MedGen UID:
104901
Concept ID:
C0206623
Neoplastic Process
Synonyms: Adenosquamous Carcinoma; Adenosquamous Carcinomas; Carcinoma, Adenosquamous; Carcinomas, Adenosquamous
SNOMED CT: Adenosquamous cell carcinoma (403902008); Adenosquamous carcinoma (403902008); Adenosquamous carcinoma (59367005); Mixed adenocarcinoma and squamous cell carcinoma (59367005); Mixed adenocarcinoma and epidermoid carcinoma (59367005)
 
Monarch Initiative: MONDO:0006074

Definition

An invasive carcinoma composed of malignant glandular cells and malignant squamous cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenosquamous carcinoma

Professional guidelines

PubMed

Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Chiang TH, Kumar A, Desai CS
J Gastrointest Surg 2022 Nov;26(11):2399-2401. Epub 2022 Aug 26 doi: 10.1007/s11605-022-05442-6. PMID: 36028730
Nica A, Marchocki Z, Gien LT, Kupets R, Vicus D, Covens A
Int J Gynecol Cancer 2021 Mar;31(3):447-451. doi: 10.1136/ijgc-2020-001785. PMID: 33649012

Recent clinical studies

Etiology

Kwak HV, Hsu DS, Chang A, Kazantsev GB, Peng PD, Spitzer AL, Chang CK
Perm J 2023 Jun 15;27(2):9-12. Epub 2022 Nov 6 doi: 10.7812/TPP/22.095. PMID: 36336674Free PMC Article
Maroldi R, Borghesi A, Ravanelli M, Golemi S, Farina D
Adv Otorhinolaryngol 2020;84:28-45. Epub 2020 Jul 30 doi: 10.1159/000457923. PMID: 32731233
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Quan J, Zhang R, Liang H, Li F, Liu H
Am Surg 2013 May;79(5):E206-8. PMID: 23635572
Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, De Winter KA, Lutgens LC, van den Bergh AC, van de Steen-Banasik E, Beerman H, van Lent M
Lancet 2000 Apr 22;355(9213):1404-11. doi: 10.1016/s0140-6736(00)02139-5. PMID: 10791524

Diagnosis

Bachmeyer C, Canard A, Wendum D, Amiot X
Am J Med 2023 Aug;136(8):e157-e158. Epub 2023 Apr 15 doi: 10.1016/j.amjmed.2023.03.031. PMID: 37068574
Kwak HV, Hsu DS, Chang A, Kazantsev GB, Peng PD, Spitzer AL, Chang CK
Perm J 2023 Jun 15;27(2):9-12. Epub 2022 Nov 6 doi: 10.7812/TPP/22.095. PMID: 36336674Free PMC Article
Shields JA, Lally SE, Milman T, Shields CL
Indian J Ophthalmol 2019 Oct;67(10):1519. doi: 10.4103/ijo.IJO_1620_19. PMID: 31546469Free PMC Article
Rao N
Semin Diagn Pathol 2014 Jul;31(4):271-7. Epub 2014 Jun 11 doi: 10.1053/j.semdp.2014.06.004. PMID: 25002356
Greer BE, Koh WJ, Abu-Rustum N, Bookman MA, Bristow RE, Campos S, Cho KR, Copeland L, Eifel P, Huh WK, Jaggernauth W, Kapp DS, Kavanagh J, Lipscomb GH, Lurain JR 3rd, Morgan M, Morgan RJ Jr, Powell CB, Remmenga SW, Reynolds RK, Secord AA, Small W Jr, Teng N; National Comprehensive Cancer Network
J Natl Compr Canc Netw 2008 Jan;6(1):14-36. doi: 10.6004/jnccn.2008.0003. PMID: 18267056

Therapy

Tewari KS, Colombo N, Monk BJ, Dubot C, Cáceres MV, Hasegawa K, Shapira-Frommer R, Salman P, Yañez E, Gümüs M, Olivera Hurtado de Mendoza M, Samouëlian V, Castonguay V, Arkhipov A, Tekin C, Li K, Toker S, Keefe SM, Lorusso D
JAMA Oncol 2024 Feb 1;10(2):185-192. doi: 10.1001/jamaoncol.2023.5410. PMID: 38095881Free PMC Article
Oaknin A, Gladieff L, Martínez-García J, Villacampa G, Takekuma M, De Giorgi U, Lindemann K, Woelber L, Colombo N, Duska L, Leary A, Godoy-Ortiz A, Nishio S, Angelergues A, Rubio MJ, Fariñas-Madrid L, Yamaguchi S, Lorusso D, Ray-Coquard I, Manso L, Joly F, Alarcón J, Follana P, Romero I, Lebreton C, Pérez-Fidalgo JA, Yunokawa M, Dahlstrand H, D'Hondt V, Randall LM; ENGOT-Cx10–GEICO 68-C–JGOG1084–GOG-3030 Investigators
Lancet 2024 Jan 6;403(10421):31-43. Epub 2023 Dec 1 doi: 10.1016/S0140-6736(23)02405-4. PMID: 38048793
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Tewari KS, Monk BJ, Vergote I, Miller A, de Melo AC, Kim HS, Kim YM, Lisyanskaya A, Samouëlian V, Lorusso D, Damian F, Chang CL, Gotovkin EA, Takahashi S, Ramone D, Pikiel J, Maćkowiak-Matejczyk B, Guerra Alía EM, Colombo N, Makarova Y, Rischin D, Lheureux S, Hasegawa K, Fujiwara K, Li J, Jamil S, Jankovic V, Chen CI, Seebach F, Weinreich DM, Yancopoulos GD, Lowy I, Mathias M, Fury MG, Oaknin A; Investigators for GOG Protocol 3016 and ENGOT Protocol En-Cx9
N Engl J Med 2022 Feb 10;386(6):544-555. doi: 10.1056/NEJMoa2112187. PMID: 35139273
Ramirez PT, Frumovitz M, Pareja R, Lopez A, Vieira M, Ribeiro R, Buda A, Yan X, Shuzhong Y, Chetty N, Isla D, Tamura M, Zhu T, Robledo KP, Gebski V, Asher R, Behan V, Nicklin JL, Coleman RL, Obermair A
N Engl J Med 2018 Nov 15;379(20):1895-1904. Epub 2018 Oct 31 doi: 10.1056/NEJMoa1806395. PMID: 30380365

Prognosis

Melamed A, Margul DJ, Chen L, Keating NL, Del Carmen MG, Yang J, Seagle BL, Alexander A, Barber EL, Rice LW, Wright JD, Kocherginsky M, Shahabi S, Rauh-Hain JA
N Engl J Med 2018 Nov 15;379(20):1905-1914. Epub 2018 Oct 31 doi: 10.1056/NEJMoa1804923. PMID: 30379613Free PMC Article
Chen YY, Li AF, Huang KH, Lan YT, Chen MH, Chao Y, Lo SS, Wu CW, Shyr YM, Fang WL
Pathol Oncol Res 2015 Jul;21(3):547-51. Epub 2015 Jan 8 doi: 10.1007/s12253-014-9890-7. PMID: 25567665
Quan J, Zhang R, Liang H, Li F, Liu H
Am Surg 2013 May;79(5):E206-8. PMID: 23635572
Houck WV, Fuller CB, McKenna RJ Jr
Ann Thorac Surg 2004 Nov;78(5):1858-60. doi: 10.1016/j.athoracsur.2003.09.139. PMID: 15511502
Turhan OI, Aydin NE, Sariyüce O
Int Urol Nephrol 1999;31(1):89-93. doi: 10.1023/a:1007180024991. PMID: 10408308

Clinical prediction guides

Lorusso D, Colombo N, Dubot C, Cáceres MV, Hasegawa K, Shapira-Frommer R, Salman P, Yañez E, Gümüş M, Olivera M, Samouëlian V, Castonguay V, Arkhipov A, Li K, Toker S, Tekin C, Tewari KS, Monk BJ
Ann Oncol 2025 Jan;36(1):65-75. Epub 2024 Oct 10 doi: 10.1016/j.annonc.2024.10.002. PMID: 39393777
Suzuki Y, Ohkura Y, Koseki M, Nomura K, Matsui A, Ueno M, Kikuchi D, Ohashi K, Hoteya S
Esophagus 2023 Jul;20(3):484-491. Epub 2023 Apr 10 doi: 10.1007/s10388-023-01003-1. PMID: 37036546
Niakan S, Patino A, Jadhav N, Hadro J, Crisi GM, Mason H
Breast J 2021 Feb;27(2):170-172. Epub 2020 Dec 25 doi: 10.1111/tbj.14143. PMID: 33368840
Ramos-Font C, Gómez-Rio M, Rodríguez-Fernández A, Jiménez-Heffernan A, Sánchez Sánchez R, Llamas-Elvira JM
J Surg Oncol 2014 Mar;109(3):218-24. Epub 2013 Oct 25 doi: 10.1002/jso.23476. PMID: 24165875
Aoki Y, Tabuse K, Wada M, Katsumi M, Uda H
Gastroenterol Jpn 1978;13(2):140-5. doi: 10.1007/BF02773859. PMID: 669198

Recent systematic reviews

Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Matsuzaki S, Klar M, Mikami M, Shimada M, Grubbs BH, Fujiwara K, Roman LD, Matsuo K
Curr Oncol Rep 2020 Feb 12;22(3):28. doi: 10.1007/s11912-020-0888-x. PMID: 32052204Free PMC Article
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Lee JY, Lee C, Hahn S, Kim MA, Kim HS, Chung HH, Kim JW, Park NH, Song YS
Int J Gynecol Cancer 2014 Feb;24(2):289-94. doi: 10.1097/IGC.0000000000000063. PMID: 24407572

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