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Signet ring cell carcinoma

MedGen UID:
61663
•Concept ID:
C0206696
•
Neoplastic Process
Synonym: Signet cell adenocarcinoma
SNOMED CT: Signet ring carcinoma (87737001); Signet ring cell carcinoma (87737001); Signet ring cell adenocarcinoma (87737001)
 
Monarch Initiative: MONDO:0005092

Definition

A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. It may arise from the stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, pancreas, lung, bladder, breast, and prostate gland. [from NCI]

Professional guidelines

PubMed

Retrospective Analysis of Diagnosis and Treatment of Gastric Cancer at Huzhou Central Hospital.
Xiang Y, Yao L
Altern Ther Health Med 2023 Nov;29(8):302-309. PMID: 37632952
Diagnosis and Management of Primary Prostatic Signet Ring Cell Carcinoma: Single-Center Experience.
Li P, Zhou Z, Bao M, Li J, Meng X, Liu B, Tang M
Am J Mens Health 2022 Mar-Apr;16(2):15579883221087839. doi: 10.1177/15579883221087839. PMID: 35315313Free PMC Article
Hereditary Diffuse Gastric Cancer: Approaches to Screening, Surveillance, and Treatment.
Pilonis ND, Tischkowitz M, Fitzgerald RC, di Pietro M
Annu Rev Med 2021 Jan 27;72:263-280. Epub 2020 Nov 20 doi: 10.1146/annurev-med-051019-103216. PMID: 33217247

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastric Cancer, 2023

Recent clinical studies

Etiology

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Hereditary Diffuse Gastric Cancer: Approaches to Screening, Surveillance, and Treatment.
Pilonis ND, Tischkowitz M, Fitzgerald RC, di Pietro M
Annu Rev Med 2021 Jan 27;72:263-280. Epub 2020 Nov 20 doi: 10.1146/annurev-med-051019-103216. PMID: 33217247
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Poorer Prognosis of Primary Signet-Ring Cell Carcinoma of the Breast Compared with Mucinous Carcinoma.
Wu X, Zhang Z, Li X, Lin Q, Chen G, Lu J, Zeng Y, Hu D, Huang K, Lin Z, Yan J
PLoS One 2016;11(9):e0162088. Epub 2016 Sep 1 doi: 10.1371/journal.pone.0162088. PMID: 27583684Free PMC Article
Hereditary gastric cancer.
Carneiro F
Pathologe 2012 Nov;33 Suppl 2:231-4. doi: 10.1007/s00292-012-1677-6. PMID: 23052347

Diagnosis

Single-cell analysis of gastric signet ring cell carcinoma reveals cytological and immune microenvironment features.
Zhao W, Jia Y, Sun G, Yang H, Liu L, Qu X, Ding J, Yu H, Xu B, Zhao S, Xing L, Chai J
Nat Commun 2023 May 24;14(1):2985. doi: 10.1038/s41467-023-38426-4. PMID: 37225691Free PMC Article
Goblet cell adenocarcinoma of the appendix: an update and practical approach to diagnosis and grading.
Bell PD, Pai RK
Hum Pathol 2023 Feb;132:183-196. Epub 2022 Jun 9 doi: 10.1016/j.humpath.2022.06.002. PMID: 35691370
The updated WHO classification of digestive system tumours-gastric adenocarcinoma and dysplasia.
Kushima R
Pathologe 2022 Feb;43(1):8-15. Epub 2021 Nov 22 doi: 10.1007/s00292-021-01023-7. PMID: 34807275
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Primary appendiceal adenocarcinoma.
Ozakyol AH, Sariçam T, Kabukçuoğlu S, Cağa T, Erenoğlu E
Am J Clin Oncol 1999 Oct;22(5):458-9. doi: 10.1097/00000421-199910000-00007. PMID: 10521058

Therapy

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Colorectal signet-ring cell carcinoma treated with FOLFOX plus panitumumab.
Matsushima S, Kobayashi R, Sano H, Hori D, Yanagi M, Goto J, Kobayashi K
Pediatr Int 2022 Jan;64(1):e15374. doi: 10.1111/ped.15374. PMID: 36169041
Crohn's Disease Following Rituximab Treatment for Follicular Lymphoma in a Patient with Synchronous Gastric Signet Ring Cells Carcinoma: A Case Report and Literature Review.
Cavalcanti E, Armentano R, Lolli I
Cancer Res Treat 2020 Oct;52(4):1291-1295. Epub 2020 Jul 13 doi: 10.4143/crt.2020.406. PMID: 32683839Free PMC Article
Undiagnosed Case of Signet Ring Cell Colorectal Carcinoma: A Case Report and Review of the Literature.
Henry M, Delavari N, Webber J
Clin Colorectal Cancer 2020 Sep;19(3):e83-e86. Epub 2020 May 8 doi: 10.1016/j.clcc.2020.04.005. PMID: 32586730
Metastatic Signet-Ring Cell Carcinoma of the Skin.
Chrysanthos NV, Nezi V, Zafiropoulou R, Papatheodoridis G, Manesis E
Am J Gastroenterol 2018 Oct;113(10):1427. doi: 10.1038/s41395-018-0099-3. PMID: 29891852

Prognosis

Metastatic Signet-Ring Cell Carcinoma of the Skin.
Chrysanthos NV, Nezi V, Zafiropoulou R, Papatheodoridis G, Manesis E
Am J Gastroenterol 2018 Oct;113(10):1427. doi: 10.1038/s41395-018-0099-3. PMID: 29891852
Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge.
Pernot S, Voron T, Perkins G, Lagorce-Pages C, Berger A, Taieb J
World J Gastroenterol 2015 Oct 28;21(40):11428-38. doi: 10.3748/wjg.v21.i40.11428. PMID: 26523107Free PMC Article
Primary signet ring cell carcinoma of the colon and rectum.
Arifi S, Elmesbahi O, Amarti Riffi A
Bull Cancer 2015 Oct;102(10):880-8. Epub 2015 Sep 26 doi: 10.1016/j.bulcan.2015.07.005. PMID: 26412710
Pulmonary lymphangitic carcinomatosis.
Lin WR, Lai RS
QJM 2014 Nov;107(11):935-6. Epub 2014 Apr 8 doi: 10.1093/qjmed/hcu076. PMID: 24713225
Primary appendiceal adenocarcinoma.
Ozakyol AH, Sariçam T, Kabukçuoğlu S, Cağa T, Erenoğlu E
Am J Clin Oncol 1999 Oct;22(5):458-9. doi: 10.1097/00000421-199910000-00007. PMID: 10521058

Clinical prediction guides

Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma.
Chen J, Liu K, Luo Y, Kang M, Wang J, Chen G, Qi J, Wu W, Wang B, Han Y, Shi L, Wang K, Han X, Ma X, Liu W, Ding Y, Wang L, Liang H, Wang L, Chen J
Gastroenterology 2023 Jul;165(1):88-103. Epub 2023 Mar 14 doi: 10.1053/j.gastro.2023.03.008. PMID: 36921674
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Appendix Tumor Microenvironment.
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Intra-abdominal recurrence from colorectal carcinoma: Differences and similarities between local and peritoneal recurrence.
Dumont F, Joseph S, Lorimier G, De Franco V, Wernert R, Verriele V, Kerdraon O, Campion L, Capitain O, Guerin-Meyer V, Raimbourg J, Senellart H, Hiret S, Raoul JL, Thibaudeau E
Surg Oncol 2020 Mar;32:23-29. Epub 2019 Nov 4 doi: 10.1016/j.suronc.2019.10.018. PMID: 31707314
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article

Recent systematic reviews

Invasive lobular carcinoma metastasis to pancreas mimicking pancreatic signet ring cell carcinoma: A case report and systematic review of the literature.
Rossi C, Gallotti A, Messina A, Cobianchi L, Inzani F, Lucioni M, Vanoli A
Pathol Res Pract 2024 Jan;253:155049. Epub 2023 Dec 21 doi: 10.1016/j.prp.2023.155049. PMID: 38176311
Clinicopathological Features and Prognostic-Related Risk Factors of Gastric Signet Ring Cell Carcinoma: A Meta-Analysis.
Guo Y, Wang Q, Tian Q, Bo C, Li N, Zhang S, Li P
Comput Math Methods Med 2022;2022:3473445. Epub 2022 Aug 5 doi: 10.1155/2022/3473445. PMID: 36035278Free PMC Article
The Molecular Associations of Signet-Ring Cell Carcinoma in Colorectum: Meta-Analysis and System Review.
Liu X, Huang L, Liu M, Wang Z
Medicina (Kaunas) 2022 Jun 21;58(7) doi: 10.3390/medicina58070836. PMID: 35888555Free PMC Article
Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study.
Lam R, Tarangelo N, Wang R, Horibe M, Grimshaw AA, Jain D, Haffar S, Bazerbachi F, Kunz PL, Li DK
Oncologist 2022 Sep 2;27(9):751-759. doi: 10.1093/oncolo/oyac093. PMID: 35589098Free PMC Article
18F-FDG PET and PET/CT for the evaluation of gastric signet ring cell carcinoma: a systematic review.
Dondi F, Albano D, Giubbini R, Bertagna F
Nucl Med Commun 2021 Dec 1;42(12):1293-1300. doi: 10.1097/MNM.0000000000001481. PMID: 34456317Free PMC Article

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastric Cancer, 2023

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