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Intraductal papilloma

MedGen UID:: 61667
•Concept ID:: C0206713
•: Neoplastic Process

Synonyms:	Intraductal Papilloma; Intraductal Papillomas; Papilloma, Intraductal; Papillomas, Intraductal
SNOMED CT:	Intraductal papilloma (5244003); Ductal papilloma (5244003); Duct adenoma (5244003)

Monarch Initiative:	MONDO:0002060

Definition

An intraluminal papillary epithelial neoplasm arising within the ducts. Representative examples are the intraductal breast papilloma and the salivary gland intraductal papilloma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIntraductal papilloma

Pathological process
- Disease
  - Neoplasm
    - Neoplasms by Histologic Type
      - Neoplasms, Glandular and Epithelial
        Neoplasms, Ductal, Lobular, and Medullary
        Intraductal papilloma
        Intraductal breast papilloma
        Atypical breast papilloma
        Central breast papilloma
        Intraductal breast papillomatosis
        Juvenile breast papillomatosis
        Microscopic breast papilloma
        Sclerosing breast papilloma
        Salivary Gland Intraductal Papilloma

Professional guidelines

PubMed

Differential Diagnosis of Benign and Malignant Breast Papillary Neoplasms on MRI With Non-mass Enhancement.

Zhou J, Li M, Liu D, Sheng F, Cai J
Acad Radiol 2023 Sep;30 Suppl 2:S127-S132. Epub 2023 Mar 9 doi: 10.1016/j.acra.2023.02.010. PMID: 36906443

Clinical practice guidelines for intraductal papilloma: Chinese Society of breast surgery (CSBrS) practice guidelines 2021.

Wu D, Shi AP, Song AL, Fan ZM; Chinese Society of Breast Surgery
Chin Med J (Engl) 2021 May 19;134(14):1658-1660. doi: 10.1097/CM9.0000000000001533. PMID: 34039866 Free PMC Article

Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.

Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

See all (27)

Recent clinical studies

Etiology

Intraductal Papillomas.

Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931

Papillary Neoplasms of the Salivary Duct System: A Review.

Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223

Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.

Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas.

Tanaka M, Fernández-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, Kimura W, Levy P, Pitman MB, Schmidt CM, Shimizu M, Wolfgang CL, Yamaguchi K, Yamao K; International Association of Pancreatology
Pancreatology 2012 May-Jun;12(3):183-97. Epub 2012 Apr 16 doi: 10.1016/j.pan.2012.04.004. PMID: 22687371

International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas.

Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S; International Association of Pancreatology
Pancreatology 2006;6(1-2):17-32. doi: 10.1159/000090023. PMID: 16327281

See all (252)

Diagnosis

Intraductal Papillomas.

Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931

Papillary neoplasms of the breast-reviewing the spectrum.

Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367

Papillary and neuroendocrine breast lesions: the WHO stance.

Tan PH, Schnitt SJ, van de Vijver MJ, Ellis IO, Lakhani SR
Histopathology 2015 May;66(6):761-70. Epub 2015 Jan 23 doi: 10.1111/his.12463. PMID: 24845113

Nipple discharge screening.

Zervoudis S, Iatrakis G, Economides P, Polyzos D, Navrozoglou I
Womens Health (Lond) 2010 Jan;6(1):135-51. doi: 10.2217/whe.09.81. PMID: 20050819

International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas.

See all (442)

Therapy

Liver abscess with Citrobacter koseri bacteremia.

Kanzawa Y, Ishimaru N, Seto H, Tsutsumi T, Kinami S
Infez Med 2018 Sep 1;26(3):266-269. PMID: 30246771

Utilization of minimally invasive breast biopsy for the evaluation of suspicious breast lesions.

Gutwein LG, Ang DN, Liu H, Marshall JK, Hochwald SN, Copeland EM, Grobmyer SR
Am J Surg 2011 Aug;202(2):127-32. Epub 2011 Feb 3 doi: 10.1016/j.amjsurg.2010.09.005. PMID: 21295284

Breast lesions with ultrasound imaging-histologic discordance at 16-gauge core needle biopsy: can re-biopsy with 10-gauge vacuum-assisted system get definitive diagnosis?

Li JL, Wang ZL, Su L, Liu XJ, Tang J
Breast 2010 Dec;19(6):446-9. Epub 2010 Sep 24 doi: 10.1016/j.breast.2010.04.003. PMID: 20869243

Scarless endoscopic papillomectomy of the breast.

Bender O, Balci FL, Yüney E, Akbulut H
Onkologie 2009 Mar;32(3):94-8. Epub 2009 Feb 13 doi: 10.1159/000195694. PMID: 19295246

Diagnosis and fine needle aspiration of intraductal papillary mucinous tumor by endoscopic ultrasound.

Bounds BC
Gastrointest Endosc Clin N Am 2002 Oct;12(4):735-45, vii. doi: 10.1016/s1052-5157(02)00031-4. PMID: 12607783

See all (31)

Prognosis

Malignant upgrade rate and associated clinicopathologic predictors for concordant intraductal papilloma without atypia: A systematic review and meta-analysis.

Keating N, Cevik J, Hopkins D, Lippey J
J Surg Oncol 2024 May;129(6):1025-1033. Epub 2024 Feb 2 doi: 10.1002/jso.27592. PMID: 38305061

Papillary Neoplasms of the Salivary Duct System: A Review.

Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223

Papillary neoplasms of the breast-reviewing the spectrum.

Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367

Liver abscess with Citrobacter koseri bacteremia.

Kanzawa Y, Ishimaru N, Seto H, Tsutsumi T, Kinami S
Infez Med 2018 Sep 1;26(3):266-269. PMID: 30246771

Histology of cystic tumors of the pancreas.

Compton CC
Gastrointest Endosc Clin N Am 2002 Oct;12(4):673-96. doi: 10.1016/s1052-5157(02)00023-5. PMID: 12607779

See all (166)

Clinical prediction guides

Malignant upgrade rate and associated clinicopathologic predictors for concordant intraductal papilloma without atypia: A systematic review and meta-analysis.

Keating N, Cevik J, Hopkins D, Lippey J
J Surg Oncol 2024 May;129(6):1025-1033. Epub 2024 Feb 2 doi: 10.1002/jso.27592. PMID: 38305061

Breast Imaging Reporting and Data System Classification for Central-Type Intra-Ductal Papillary Masses: Current Problems and Evaluation of Modified Parameters.

Zhang H, Sun Y, Zhang J, Wang S
Ultrasound Med Biol 2021 Apr;47(4):960-966. Epub 2021 Jan 15 doi: 10.1016/j.ultrasmedbio.2020.12.005. PMID: 33455809

Papilloma diagnosed on core biopsies has a low upgrade rate.

Li X, Aho M, Newell MS, Clifford K, Patel JG, Jou S, Cohen MA
Clin Imaging 2020 Mar;60(1):67-74. Epub 2019 Dec 3 doi: 10.1016/j.clinimag.2019.10.009. PMID: 31864203

Liquid biopsy in the diagnosis of HPV DNA in breast lesions.

Carolis S, Pellegrini A, Santini D, Ceccarelli C, De Leo A, Alessandrini F, Arienti C, Pignatta S, Tesei A, Mantovani V, Zamagni C, Taffurelli M, Sansone P, Bonafé M, Cricca M
Future Microbiol 2018 Feb;13:187-194. Epub 2017 Oct 4 doi: 10.2217/fmb-2017-0145. PMID: 28975808

Surgical management of high-risk breast lesions.

Degnim AC, King TA
Surg Clin North Am 2013 Apr;93(2):329-40. Epub 2013 Feb 8 doi: 10.1016/j.suc.2012.12.005. PMID: 23464689

See all (170)