GEO DataSets

(Submitter supplied) The aim was to examine the acute effects of sprint exercise (SIT) on global gene expression in subcutaneous adipose tissue (AT) in healthy subjects to improve the understanding of how SIT may contribute to the maintenance of a healthy body weight. An SIT-induced upregulation of genes related to mitochondrial and fat metabolism was hypothesized. A total of 15 subjects performed three 30-s all-out sprints (SIT). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

18 Samples

Download data: CEL, CHP

(Submitter supplied) Cisplatin-based combination chemotherapy (CHT) is standard of care in locally advanced and metastatic urothelial cancer (mUC). No predictive biological biomarkers are available for clinical use. Here, we investigate the impact of molecular subtypes in relation to response and survival in mUC patients treated with first-line CHT. Molecular subtype classification according to Lund taxonomy was performed by tumour transcriptomic profiling and immunostaining in a retrospective cohort with mUC patients treated with CHT. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

20 Samples

Download data: CEL, TXT

(Submitter supplied) Mast cells respond to acute and chronic exposure to IL-33 by differing the expression of their receptors, cytokines and proteases. We aim to characterize the distinct acute and chronic responses of mast cells to IL-33 by analyzing hCBMC expression profile of pro- and anti- inflammatory mediators.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

10 Samples

Download data: CEL

(Submitter supplied) Lung resident mesenchymal stem cells exert a pivotal role in tissue repair. Idiopathic pulmonary fibrosis is characterized by an aberrant tissue repair. We performed a transcriptomic analysis to characterize lung resident mesenchymal stem cells from idiopathic pulmonary fibrosis patients

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

8 Samples

Download data: CEL

(Submitter supplied) The project aims to attain deeper insight into the role of TRPM7 in the regulation of cellular pathways. We identified a set of differently expressed genes in HAP1 cells after the genetic or pharmacological inactivation of TRPM7.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

4 Samples

Download data: CEL, XLS

(Submitter supplied) Mast cells are tissue-resident innate immune cells that express high affinity to receptor immunoglobulin E and responsible for host defense and array of diseases relate to immune system. We aim to characterize the function of human umbilical cord blood-dervied mast cells (hCBMCs).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

5 Samples

Download data: CEL

(Submitter supplied) Helicobacter pylori (H. pylori) is a human pathogen that infects almost half of the world’s population. Infection with H. pylori is frequently associated with chronic gastritis and can even lead to gastric and duodenal ulcers and gastric cancer. Although the persistent colonization of H. pylori and the development of H. pylori-associated gastritis remain poorly understood, it is believed that, in gastric mucosa, the modulated gastric epithelial cells (GECs) by H. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL23159 GPL6244

21 Samples

Download data: CEL

(Submitter supplied) Prolonged metabolic stress can lead to severe pathologies. In metabolically challenged primary fibroblasts, we assigned a novel role for the poorly characterized miR-4734 in restricting ATF4 and IRE1-mediated upregulation of a set of pro-inflammatory cytokines and endoplasmic reticulum (ER) stress-associated genes. Conversely, inhibition of this miRNA augmented the expression of those genes. Mechanistically, miR-4734 was found to restrict the expression of NFKBIZ, that is required for optimal expression of the pro-inflammatory genes and whose mRNA is targeted directly by miR-4734. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

9 Samples

Download data: CEL, XLSX

(Submitter supplied) MVPC isolated from explanted lung tissue at VUMC.; Control MVPC - 3 independent patients, mTOR activated MVPC - 3 lines 1 patient; Fetal 3 independent patients. Fetal lung MSC 3 independent patients LAM MVPC - 1 patient 3 different parts of lung; Fetal lung MVPC 3 independent patients; Control MVPC - 3 independent patients To elucidate pathways in human MVPC that were affected by mTOR activation, transcriptome expression analysis via microarray comparing primary human lung MVPC from normal control, mTOR+ and fetal lung was performed. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

9 Samples

Download data: CEL

(Submitter supplied) Comparative transcriptome of SW1222 colorectal cancer (CRC) cells that overexpress or are depleted of DPPA3 to identify genes involved in regulating of the slow-cycling cancer cell properties to uncover the molecular mechanism of the non-mutational chemoresistant phenotype.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

24 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:

GPL10123 GPL4091 GPL6244

137 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) This experiment investigates global gene expression in adenoid cystic carcinoma (30) and normal salivary gland tissue (7).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

37 Samples

Download data: CEL, CHP

(Submitter supplied) The aim of this study was to identify at genome-wide level, the effect of miR-122 on the distribution of its responsive genes on the polyribosomes. For this purpose human hepatoma cells Huh-7 were transfected for 48 hrs with LNA-based miR-122 inhibitors (122-PM) or miR-122 mimics (122-MIM). Following the treatment with cycloheximide, cells were lysed and layered on a 10-50% sucrose gradient. Following ultracetrifigation the polyribosomes were separated in 12 different fractions

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

12 Samples

Download data: CEL, CHP

(Submitter supplied) Transcription factor NRF1 (NFE2L1) has been reported to be activated by proteasome disfunction, although the target genes are poorly understood. We used microarrays to identify NRF3-regulated gene expression network related to proteostasis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

4 Samples

Download data: CEL, CHP

(Submitter supplied) Balanced immune responses in airways of patients with asthma are crucial to succesful clearance of viral infection and proper asthma control. We used microarrays to detail the global programme of gene expression data from bronchial brushings from control individuals and patients with asthma after rhinovirus infection in vivo.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

48 Samples

Download data: CEL

(Submitter supplied) The canonical function of EZH2 is methylation of H3K27, although important non-canonical roles have recently been described. EZH2 mutation or deregulated expression has been conclusively demonstrated in the pathogenesis and response to treatment of acute myeloid leukemia (AML), thus making it an attractive therapeutic target. In this study, we therefore investigated whether inhibition of EZH2 might also improve the response of non-APL AML cells to ATRA-based therapy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

42 Samples

Download data: CEL, CHP

(Submitter supplied) EVALUATING THE GENE EXPRESSION PROFILE OF PROSTATIC TUMOR CELL IN CO-CULTURE WITH HUMAN ASTROCYTE AND THE TRANSCRIPTIONAL REPROGRAMMING IN ASTROCYTS BY CONTACTING WITH TUMOR CELLS DNA MICROARRAY WAS APPLIED AIMING TO EVALUATE THE GENE EXPRESSION PROFILE

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

14 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL6480 GPL6244

28 Samples

Download data: CEL

(Submitter supplied) Stem-like cells of nasopharyngeal cancer were enriched by 3 different methods: 1) Side population (SP) assay, 2) LMP2A over-expression and 3) spheroid culture. SP cells and LMP2A over-expressed cells were inoculated into immunocompromised mice for xenograft tumors. Transcriptomes of all 5 of these in vitro and in vivo generated NPC stem-like cells were then analyzed and compared to their counterparts by microarray. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

6 Samples

Download data: CEL