Similar studies for GEO DataSets (Select 200197326) - GEO DataSets

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Items: 20

Select item 2001973261.

Next-generation sequencing reveals the regulatory mechanism of transcription factor Foxk1 in the liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL21103
56 Samples

Download data: BW

Series

Accession:: GSE197326

ID:: 200197326

PubMed Similar studies

Select item 2000896262.

Identifying the role of Acox1 in metabolism and inflammation in non-alcoholic fatty liver disease through mRNA-sequencing.

(Submitter supplied) Purpose: To identify the impact of Acox1 on cellular metabolism and inflammation related to non-alcoholic fatty liver disease, within the context of obesogenic dietary stress. Methods: Hepatic mRNA profiles were obtained in triplicate for control and Acox1Lampe1 mice on chow diet or obesogenic diet. Profiles were generated using the Illumina HiSeq2000, reads that passed quality inspection were processed through the TopHap/Cufflinks pipeline. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: TXT

Series

Accession:: GSE89626

ID:: 200089626

PubMed Full text in PMC Similar studies

Select item 2000770843.

Liver of MAT1A WT and MAT1A KO mice treated with placebo or SAMe during 8 weeks

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Methylation profiling by high throughput sequencing

Platforms:: GPL16173 GPL6887
38 Samples

Download data

Series

Accession:: GSE77084

ID:: 200077084

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000770824.

Gene expression analysis of the liver of MAT1A WT and MAT1A KO mice treated with placebo or SAMe during 8 weeks

(Submitter supplied) Methionine adenosyltransferase (MAT) enzymes generate SAMe (S-adenosylmethionine), the main biological methyl donor. There are two MAT encoding genes in mammals (Mat1a and Mat2a), which show different activities and cellular distribution. Mat1a encodes the enzyme mainly expressed in normal liver. Mat1a ablation in mice results in the spontaneous development of non-alcoholic steatohepatitis (NASH). We observed that SAMe depletion in Mat1a KO mice had three main effects on hepatic lipid metabolism: 1) impaired TG (triglyceride) export via VLDL; 2) impaired mitochondrial FA (fatty acid) oxidation (as evidenced by membrane depolarization, downregulation of Phb1 (prohibitin 1, a mitochondrial chaperone protein) and Mcj/Dnajc15 (endogenous mitochondrial repressor of respiratory chain), and accumulation of long-chain acylcarnitines); and 3) increased FA uptake. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
19 Samples

Download data: TXT

Series

Accession:: GSE77082

ID:: 200077082

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000770795.

DNA methylation status of the liver of MAT1A WT and MAT1A KO mice treated with placebo or SAMe during 8 weeks

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL16173
19 Samples

Download data: TXT

Series

Accession:: GSE77079

ID:: 200077079

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001209776.

Transcriptomic analysis of liver mRNA from TSP-1 KO and WT mice fed with normal diet or choline deficient amino acid defined diet (CDAHFD, human NASH model)

(Submitter supplied) Transcriptomic profiles of wild type and TSP1 knockout mice that were fed control (normal) diet or CDAHFD (choline deficient amino acid defiend high fat diet) chow for 12 weeks to model Non-alcoholic Steatohepatitis (NASH) disease in humans.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
20 Samples

Download data: TXT

Series

Accession:: GSE120977

ID:: 200120977

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001246947.

Arid1a loss drives non‐alcoholic steatohepatitis in mice via epigenetic dysregulation of hepatic lipogenesis and fatty acid oxidation

(Submitter supplied) ARID1A, a DNA-binding component of the SWI/SNF ATP-dependent chromatin-remodeling complex, contributes to nucleosome repositioning and access by transcriptional regulators. Liver-specific deletion of Arid1a (Arid1a LKO) caused the development of age-dependent fatty liver disease in mice. Transcriptome analysis revealed upregulation of lipogenesis and down-regulation of fatty acid oxidation genes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: TXT

Series

Accession:: GSE124694

ID:: 200124694

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001268488.

HEPATIC TRANSCRIPTOME SIGNATURES IN PATIENTS WITH VARYING DEGREES OF NON-ALCOHOLIC FATTY LIVER DISEASE COMPARED TO HEALTHY NORMAL-WEIGHT INDIVIDUALS

(Submitter supplied) Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of conditions ranging from simple steatosis (NAFL), over non-alcoholic steatohepatitis (NASH) with or without fibrosis, to cirrhosis with end-stage disease. The hepatic molecular events underlying the development of NAFLD and transition to NASH are poorly understood. The present study aimed to determine hepatic transcriptome dynamics in patients with NAFL or NASH compared to healthy normal-weight and obese individuals. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
57 Samples

Download data: TXT

Series

Accession:: GSE126848

ID:: 200126848

Select item 2002553569.

A 5:2 intermittent fasting regimen initiated in the active phase ameliorates NASH, fibrosis and blunts HCC development via hepatic PPARα and PCK1

(Submitter supplied) The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic steatohepatitis (NASH) and its transition to hepatocellular carcinoma (HCC) are unknown. Here, we identified that an IF 5:2 regimen (two non-consecutive days of food deprivation per week), initiated in the active phase of mice, prevents NASH development as well as ameliorates established NASH and fibrosis without affecting total calorie intake. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
39 Samples

Download data: TSV, TXT

Series

Accession:: GSE255356

ID:: 200255356

PubMed Similar studies

Select item 20013356610.

Shp-deletion induces dissociation of steatosis and inflammation in NASH

(Submitter supplied) Two months-old Shp flox/flox male mice were injected with either AAV8 expressing Cre recombinase driven by the thyroxine-binding globulin (Tbg) promoter (AAV8-Tbg-Cre) or control AAV8 (AAV8-Tbg-null) and fed chow or a diet enriched in high fat, cholesterol, and fructose (Research diet D09100301: 40 kcal% fat, 2% cholesterol, 20 kcal% fructose, hereafter referred to as HFCF diet) for 3 months. Liver RNA was isolated and submitted to RNA-seq.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15103
12 Samples

Download data: TXT

Series

Accession:: GSE133566

ID:: 200133566

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017229711.

RNA-seq analysis of control, NASH, and TH-treated NASH liver

(Submitter supplied) We performed RNA-seq analysis of pooled RNA extracted from liver of mice fed normal chow (control), WDF (NASH), and WDF+TH (TH-treated NASH).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
3 Samples

Download data: TXT

Series

Accession:: GSE172297

ID:: 200172297

PubMed Similar studies SRA Run Selector

Select item 20011807012.

High-fat diet induces the modulation of hepatic nuclear receptors and their target genes in C57BL/6 mice

(Submitter supplied) We reported the hepatic gene expression profiling in mice fed with a high fat diet compared to the controls. We found that the modulation of pathways related to peroxisome proliferator-activated receptors, cytochrome P450s, and ATP-binding cassette transporters in high fat diet mice. Particularly, constitutive androstane receptor and pregnane X receptor signature genes Cyp2b10 and Cyp3a11 were significantly increased in high fat diet mice compared to controls. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: XLSX

Series

Accession:: GSE118070

ID:: 200118070

PubMed Similar studies SRA Run Selector

Select item 20005729013.

Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model

(Submitter supplied) BCAA were administered to atherogenic and high-fat (Ath & HF) diet-induced nonalcoholic steatohepatitis (NASH) model mice and platelet-derived growth factor C transgenic mice (Pdgf-c Tg). Liver histology, tumor incidence, and gene expression profiles were evaluated. BCAA supplementation improved hepatic steatosis, inflammation, fibrosis, and tumors in the NASH mouse model, possibly through the modification of mTORC1 signaling.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
15 Samples

Download data: CEL

Series

Accession:: GSE57290

ID:: 200057290

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20019255414.

NCOA5 haploinsufficiency in myeloid cells sufficiently causes non-alcoholic steatohepatitis and hepatocellular carcinoma

(Submitter supplied) Molecular and cellular mechanisms causing the onset and progression of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and HCC remain poorly understood. Here we show that myeloid-cell-specific heterozygous deletion of Ncoa5 (Ncoa5ΔM/+) sufficiently causes the development of NAFLD/NASH and HCC in male mice. The platelet factor 4 (PF4) overexpressed by Ncoa5ΔM/+ intrahepatic macrophages is identified as a potent mediator to trigger lipid accumulation in hepatocytes by inducing expression of genes promoting lipogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: CSV, TAR

Series

Accession:: GSE192554

ID:: 200192554

PubMed Full text in PMC Similar studies

Select item 20017610815.

Effect of childhood ionizing radiation exposure and calorie restriction on NASH-like pathological disorder induction and hepatocellular carcinoma development in mouse model

(Submitter supplied) To investigate gene expression patterns in mouse hepatocytes induced by ionizing radiation and calorie restriction.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
42 Samples

Download data: TXT

Series

Accession:: GSE176108

ID:: 200176108

Select item 20018591116.

Liver lipophagy ameliorates nonalcoholic steatohepatitis through lysosomal lipid exocytosis

(Submitter supplied) Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid accumulation and subsequent inflammatory and profibrotic response. Lipid reduction through cytoplasmic lipolysis might adversely worsen steatohepatitis, however, the effect of autophagic lipolysis, lipophagy, remains obscure. We engineered the adaptor protein to induce lipophagy with lipid droplet targeting signal and modified LC3 interacting region. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE185911

ID:: 200185911

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20023034417.

FoxK1 Associated Gene Regulatory Network in Hepatic Insulin Action and It’s Relationship to FoxO and Insulin Receptor Mediated Transcriptional Regulation

(Submitter supplied) ChIP-seq analysis demonstrates FoxK1 binding to proximal promoters and enhancers, especially to genes containing a TGTTTAC motif, which is similar to the FoxA/FoxO motifs.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE230344

ID:: 200230344

PubMed Full text in PMC Similar studies

Select item 20021443518.

Disseminative Recurrence Signature for hepatocellular carcinoma from non-alcoholic fatty liver disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
104 Samples

Download data

Series

Accession:: GSE214435

ID:: 200214435

PubMed Full text in PMC Similar studies

Select item 20021443219.

Transcriptome profile of hepatocellular carcinoma from non-alcoholic fatty liver.

(Submitter supplied) Non-alcoholic fatty liver disease (NAFLD) is a major global health problem with its high prevalence and risk of developing lethal complications, progressive liver fibrosis and hepatocellular carcinoma (HCC), the only rising cancer mortality in the U.S. Ever after curative surgical resection, HCC can recur at extremely high rate (70% within 5 years); therefore, prediction of recurrent HCC is expected to guide decision of neo/adjuvant therapies currently under active development. more...