GEO DataSets

Analysis of primary plasmacytoid dendritic cells (pDC) exposed to influenza A for 8 hours ex vivo. pDCs are vital to antiviral defense, directing immune responses via secretion of interferon-alpha. Results provide insight into the regulation of the response of pDC to viral pathogens.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 individual, 2 infection sets

Platform:

GPL10558

Series:

GSE68849

10 Samples

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Analysis of U251 astrocyte cells infected with the influenza H5N1 virus for up to 24 hours. Results provide insight into the immune response of astrocytes to H5N1 infection.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 infection, 3 time sets

Platform:

GPL6480

Series:

GSE66597

18 Samples

Download data: TXT

Analysis of pulmonary CDC11c+ cells from 6-8 week and 10-13 month old C57BL/6 animals. CDC11c+ cells are key modulators of the immune response in the lung. Results provide insight into molecular mechanisms underlying the decline in immune function associated with aging.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL6885

Series:

GSE71868

8 Samples

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Analysis of proteasome inhibitor carfilzomib-resistant multiple myeloma (MM) cell lines KMS-11/Cfz and KMS-34/Cfz, after 1 week of growth in the absence of carfilzomib. Results provide insight into the molecular mechanisms underlying the acquisition of proteasome inhibitor resistance in MM.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 cell line, 2 cell type sets

Platform:

GPL570

Series:

GSE69078

12 Samples

Download data: CEL

Analysis of spinal cord segment from interleukin (IL)-1α -/- and IL-1β -/- C57BL/6 adults 24 hrs after spinal cord injury (SCI). IL-1α and IL-1β belong to a family of cytokines playing a key role in neurodegeneration. Results provide insight into the role of IL-1α in the neuropathology of SCI.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL6246

Series:

GSE70302

12 Samples

Download data: CEL

Analysis of soleus muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE70213

12 Samples

Download data: CEL

Analysis of quadriceps muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE70213

12 Samples

Download data: CEL

Analysis of retinal pigment epithelial ARPE-19 cells treated with SRPIN803, a small molecule inhibitor of serine-arginine protein kinase 1 SRPK1. SRPK1 inhibition prevents pathological angiogenesis. Results provide insight into the molecular mechanisms underlying the inhibitory activity of SRPIN803.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL570

Series:

GSE62947

6 Samples

Download data: CEL

Analysis of GM-CSF myeloid dendritic cells (GM-DCs) isolated from interleukin-2 (IL-2) knockouts and activated with curdlan, a pathogen-associated molecular pattern (PAMP). GM-DCs secrete cytokines such as IL-2, upon PAMP activation. Results provide insight into role of IL-2 signaling in DCs.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE58120

12 Samples

Download data: CEL

Analysis of estrogen receptor (ER)-positive breast cancer cell line MCF-7 depleted for KDM3A (histone lysine demethylase 3A) then treated with estrogen. Histone lysine methylation is an important regulator of transcription. Results provide insight into role of KDM3A in ER signaling in breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL10558

Series:

GSE68918

11 Samples

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Analysis of cultured vascular smooth muscle cells following knockdown of zipper-interacting protein kinase (ZIPK). ZIPK is phosphorylated and activated by Rho-associated kinase 1 (ROCK1). These results, together with those from GDS5659, provide further insight into ROCK1 and ZIPK functions.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6244

Series:

GSE56819

6 Samples

Download data: CEL

Analysis of cultured vascular smooth muscle cells following knockdown of Rho-associated kinase 1 (ROCK1). ROCK1 phosphorylates and activates zipper-interacting protein kinase (ZIPK). These results, together with those from GDSxxxx, provide further insight into ROCK1 and ZIPK functions.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6244

Series:

GSE56819

6 Samples

Download data: CEL

Analysis of RAW 264.7 macrophages pre-treated with vitamin A derivative 9cis-retinoic acid (9cRA), then stimulated with bacterial LPS or viral mimetic polyI:C. 9cRA is a high affinity ligand for retinoid X receptor (RXR). Results provide insight into the role of RXR in host antiviral response.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 3 stress sets

Platform:

GPL1261

Series:

GSE62107

6 Samples

Download data: CEL, CHP

Analysis of TEL-AML1 oncogene-expressing hematopoietic stem/progenitor cell line EML1 treated with interleukin 7 (IL7) and FLT3 ligand (FLT3L) for up to 7 days. IL7 and FLT3L treatment induces B-cell differentiation. Results provide insight into the role of TEL-AML1 in early B-cell differentiation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 protocol, 3 time sets

Platform:

GPL11533

Series:

GSE64919

12 Samples

Download data: CEL

Analysis of MEFs treated for 24hrs with ligands lipopolysaccharide (LPS), lymphotoxin-β receptor agonist antibody (LTβR), and LPS+ LTβR. Results provide insight into molecular mechanisms underlying a potentially synergistic effect of LTβR signaling on LPS-TLR4 signaling.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 protocol sets

Platform:

GPL6885

Series:

GSE62301

4 Samples

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Analysis of gastrocnemius muscle from starved males with muscle-specific deletion of Forkhead Box O transcription factors 1, 3 and 4 (FoxO1,3,4-/-). Results provide insight into the collective roles of FoxOs during muscle atrophy.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 stress sets

Platform:

GPL1261

Series:

GSE52667

4 Samples

Download data: CEL

Analysis of LNCaP prostate cancer (PCa) cells overexpressing miRNA-135b for up to 36 hours. LNCaP cells express the androgen receptor (AR). MiRNA-135b overexpression in AR+ PCa cells results in slower growth compared to AR knockdown. Results provide insight into the basis of this slower growth.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 protocol, 3 time sets

Platform:

GPL10558

Series:

GSE57820

12 Samples

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Analysis of myogenic stem cells called satellite cells (mSCs) FACS-sorted from the trunk of Pax3GFP/+ mice at postnatal days 1, 12, and 28, a period when most mSCs are in proliferation and quiescence states. Results provide insight into molecular basis of early postnatal skeletal muscle development.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 age, 2 tissue sets

Platform:

GPL1261

Series:

GSE65927

11 Samples

Download data: CEL

Analysis of cochlea from 4 wk old DBA/2J males (a model of progressive hearing loss) injected for 8 wks with a combination of epigenetic modifiers l-methionine and valproic acid. Results provide insight into the effect of epigenetic modifications on the molecular mechanisms underlying hearing loss.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 3 protocol sets

Platform:

GPL1261

Series:

GSE62173

16 Samples

Download data: CEL

Analysis of PBMCs isolated from an IRF7-deficient patient and infected with influenza A/CA/4/2009 for up to 16 hrs. Transcription factor IRF7 amplifies type I and III interferon response to viruses. Results provide insight into the role of IRF7 in antiviral immunity.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 6 individual, 2 infection, 3 time sets

Platform:

GPL10558

Series:

GSE66486

18 Samples

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