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Ten-a Tenascin accessory [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32183, updated on 9-Dec-2024

Summary

Official Symbol
Ten-aprovided by FlyBase
Official Full Name
Tenascin accessoryprovided by FlyBase
Primary source
FLYBASE:FBgn0267001
Locus tag
Dmel_CG42338
See related
AllianceGenome:FB:FBgn0267001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1.2; cbd; CG11270; CG12720; CG15733; CG18182; CG2578; CG2590; CG32659; CG42338; Dmel\CG42338; Dmtena; DmtenA; ten-a; Ten11A; tenA; tenA(AT)[[14]]; ten[a]; Ten[a]
Old locus tag
Dmel_CG12720; Dmel_CG15733; Dmel_CG32659
Summary
Enables protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including nervous system development; regulation of cell-cell adhesion; and synapse organization. Located in several cellular components, including cytoskeleton of presynaptic active zone; neuromuscular junction; and presynaptic membrane. Is expressed in several structures, including adult olfactory antennal lobe glomerulus; anterior-posterior subdivision of organism; direct flight muscle precursor cell; neuron projection bundle of larval ventral nerve cord; and olfactory system neurons. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human TENM2 (teneurin transmembrane protein 2) and TENM3 (teneurin transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Ten-a in Genome Data Viewer
Location:
11A2-11A8; 1-38 cM
Exon count:
25
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12043698..12335214)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11937731..12229247)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43960 Neighboring gene Cytochrome P450 311a1 Neighboring gene Cytochrome P450 318a1 Neighboring gene long non-coding RNA:CR43961 Neighboring gene long non-coding RNA:CR32657 Neighboring gene Uch-L5-related Neighboring gene long non-coding RNA:CR32658 Neighboring gene Mucin 11A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene moonshiner Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 11a

Genomic regions, transcripts, and products

Bibliography

Related articles in PubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

mobile_element

  • Loc: 12163544-12163806 mobile_element_type = transposon:INE-1{}1864
  • Loc: 12168193-12173562 mobile_element_type = transposon:I{}112

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in central complex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of alignment of postsynaptic density and presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
involved_in maintenance of alignment of postsynaptic density and presynaptic active zone IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of presynaptic active zone structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of homotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of terminal button organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic target attraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic target recognition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoskeleton of presynaptic active zone IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tenascin accessory
Names
CG42338-PD
CG42338-PE
CG42338-PF
CG42338-PG
CG42338-PI
CG42338-PK
CG42338-PL
CG42338-PM
CG42338-PN
CG42338-PO
CG42338-PP
Ten-a-PD
Ten-a-PE
Ten-a-PF
Ten-a-PG
Ten-a-PI
Ten-a-PK
Ten-a-PL
Ten-a-PM
Ten-a-PN
Ten-a-PO
Ten-a-PP
Teneurin-a
central body defect
central-body-defect
tenascin-like molecule accessory
teneurin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12043698..12335214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169259.3NP_001162730.2  tenascin accessory, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162730.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z145, E1JJM3
    Conserved Domains (9) summary
    COG3209
    Location:23882949
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:11621192
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:16661712
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:29303006
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:9981162
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:22042241
    RHS_repeat; RHS Repeat
    pfam07974
    Location:10321057
    EGF_2; EGF-like domain
    pfam15636
    Location:32653340
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:16131918
    NHL; NHL repeat unit of beta-propeller proteins
  2. NM_001169261.3NP_001162732.2  tenascin accessory, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162732.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYN8
    Conserved Domains (9) summary
    COG3209
    Location:23972958
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:11631192
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:16751721
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:29393015
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:9981162
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:22132250
    RHS_repeat; RHS Repeat
    pfam07974
    Location:10321057
    EGF_2; EGF-like domain
    pfam15636
    Location:32743349
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:16221927
    NHL; NHL repeat unit of beta-propeller proteins
  3. NM_001169260.3NP_001162731.1  tenascin accessory, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162731.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24550, Q9VYN8
    UniProtKB/TrEMBL
    M9PJK5
    Conserved Domains (9) summary
    COG3209
    Location:20142575
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:789818
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:12921338
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25562632
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:624788
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:18301867
    RHS_repeat; RHS Repeat
    pfam07974
    Location:658683
    EGF_2; EGF-like domain
    pfam15636
    Location:28912966
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12391544
    NHL; NHL repeat unit of beta-propeller proteins
  4. NM_001144718.3NP_001138190.1  tenascin accessory, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138190.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24550, Q9VYN8
    UniProtKB/TrEMBL
    M9PJK5
    Conserved Domains (9) summary
    COG3209
    Location:20142575
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:789818
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:12921338
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25562632
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:624788
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:18301867
    RHS_repeat; RHS Repeat
    pfam07974
    Location:658683
    EGF_2; EGF-like domain
    pfam15636
    Location:28912966
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12391544
    NHL; NHL repeat unit of beta-propeller proteins
  5. NM_001144717.4NP_001138189.1  tenascin accessory, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138189.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z145, E1JJM3
    Conserved Domains (9) summary
    COG3209
    Location:23882949
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:11621192
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:16661712
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:29303006
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:9981162
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:22042241
    RHS_repeat; RHS Repeat
    pfam07974
    Location:10321057
    EGF_2; EGF-like domain
    pfam15636
    Location:32653340
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:16131918
    NHL; NHL repeat unit of beta-propeller proteins
  6. NM_001272554.2NP_001259483.1  tenascin accessory, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259483.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24550, Q9VYN8
    UniProtKB/TrEMBL
    M9PJK5
    Conserved Domains (9) summary
    COG3209
    Location:20142575
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:789818
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:12921338
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25562632
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:624788
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:18301867
    RHS_repeat; RHS Repeat
    pfam07974
    Location:658683
    EGF_2; EGF-like domain
    pfam15636
    Location:28912966
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12391544
    NHL; NHL repeat unit of beta-propeller proteins
  7. NM_001258713.2NP_001245642.1  tenascin accessory, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245642.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NF26
    Conserved Domains (9) summary
    COG3209
    Location:20232584
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:789818
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:13011347
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25652641
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:624788
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:18391876
    RHS_repeat; RHS Repeat
    pfam07974
    Location:658683
    EGF_2; EGF-like domain
    pfam15636
    Location:29002975
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12481553
    NHL; NHL repeat unit of beta-propeller proteins
  8. NM_001258712.2NP_001245641.1  tenascin accessory, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245641.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NF26
    Conserved Domains (9) summary
    COG3209
    Location:20232584
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:789818
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:13011347
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25652641
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:624788
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:18391876
    RHS_repeat; RHS Repeat
    pfam07974
    Location:658683
    EGF_2; EGF-like domain
    pfam15636
    Location:29002975
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12481553
    NHL; NHL repeat unit of beta-propeller proteins
  9. NM_001258711.2NP_001245640.1  tenascin accessory, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24550, Q9VYN8
    UniProtKB/TrEMBL
    M9PJK5
    Conserved Domains (9) summary
    COG3209
    Location:20142575
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:789818
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:12921338
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25562632
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:624788
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:18301867
    RHS_repeat; RHS Repeat
    pfam07974
    Location:658683
    EGF_2; EGF-like domain
    pfam15636
    Location:28912966
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12391544
    NHL; NHL repeat unit of beta-propeller proteins
  10. NM_001169258.2NP_001162729.1  tenascin accessory, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162729.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJM6
    Conserved Domains (9) summary
    COG3209
    Location:19122473
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:687716
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:11901236
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24542530
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:522686
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:17281765
    RHS_repeat; RHS Repeat
    pfam07974
    Location:556581
    EGF_2; EGF-like domain
    pfam15636
    Location:27892864
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:11371442
    NHL; NHL repeat unit of beta-propeller proteins
  11. NM_078582.4NP_511137.3  tenascin accessory, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511137.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24550, Q9VYN8
    UniProtKB/TrEMBL
    M9PJK5
    Related
    FBpp0289136
    Conserved Domains (9) summary
    COG3209
    Location:20142575
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:789818
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:12921338
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25562632
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:624788
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:18301867
    RHS_repeat; RHS Repeat
    pfam07974
    Location:658683
    EGF_2; EGF-like domain
    pfam15636
    Location:28912966
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12391544
    NHL; NHL repeat unit of beta-propeller proteins