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RAD2 ssDNA endodeoxyribonuclease RAD2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853174, updated on 9-Dec-2024

Summary

Official Symbol
RAD2
Official Full Name
ssDNA endodeoxyribonuclease RAD2
Primary source
SGD:S000003490
Locus tag
YGR258C
See related
AllianceGenome:SGD:S000003490; FungiDB:YGR258C; VEuPathDB:YGR258C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables single-stranded DNA endodeoxyribonuclease activity. Involved in nucleotide-excision repair and transcription by RNA polymerase II. Part of nucleotide-excision repair factor 3 complex. Used to study Cockayne syndrome and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; melanoma; respiratory system cancer (multiple); stomach cancer; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See RAD2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1007671..1010766, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene phosphogluconate dehydrogenase (decarboxylating) GND2 Neighboring gene Mtm1p Neighboring gene Tna1p Neighboring gene Apl6p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA endonuclease activity  
enables DNA nuclease activity  
enables endonuclease activity  
enables metal ion binding  
enables single-stranded DNA binding  
enables single-stranded DNA binding  
enables single-stranded DNA endodeoxyribonuclease activity PubMed 
Component Evidence Code Pubs
part_of nucleotide-excision repair factor 3 complex PubMed 
is_active_in nucleus  
located_in nucleus  

General protein information

Preferred Names
ssDNA endodeoxyribonuclease RAD2
NP_011774.1
  • Single-stranded DNA endonuclease; cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1007671..1010766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181387.1 → NP_011774.1  TPA: ssDNA endodeoxyribonuclease RAD2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011774.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV38, E9P8X9, P07276
    UniProtKB/TrEMBL
    C7GNH3, N1P444
    Conserved Domains (1) summary
    TIGR00600
    Location:1 → 1030
    rad2; DNA excision repair protein (rad2)
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