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    MSF1 phenylalanine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856160, updated on 4-Jan-2025

    Summary

    Official Symbol
    MSF1
    Official Full Name
    phenylalanine--tRNA ligase
    Primary source
    SGD:S000006251
    Locus tag
    YPR047W
    See related
    AllianceGenome:SGD:S000006251; FungiDB:YPR047W; VEuPathDB:YPR047W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phenylalanine-tRNA ligase activity. Involved in mitochondrial phenylalanyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See MSF1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (657529..658938)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Thp3p Neighboring gene Mcm16p Neighboring gene NAPDH-dependent diflavin reductase Neighboring gene autophagy protein ATG11

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables aminoacyl-tRNA ligase activity  
    enables catalytic activity, acting on a tRNA  
    enables phenylalanine-tRNA ligase activity  
    enables phenylalanine-tRNA ligase activity PubMed 
    enables phenylalanine-tRNA ligase activity  
    enables phenylalanine-tRNA ligase activity PubMed 
    enables tRNA binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    phenylalanine--tRNA ligase
    NP_015372.2
    • Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      657529..658938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184144.1 → NP_015372.2  TPA: phenylalanine--tRNA ligase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015372.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W455, P08425, Q12410
      UniProtKB/TrEMBL
      A6ZWT8, B3LLA5, C7GY36, C8ZJ72, G2WPM3
      Conserved Domains (1) summary
      TIGR00469
      Location:18 → 468
      pheS_mito; phenylalanyl-tRNA synthetase, mitochondrial
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