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    Delta delta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42313, updated on 17-Dec-2024

    Summary

    Official Symbol
    Deltaprovided by FlyBase
    Official Full Name
    deltaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000463
    Locus tag
    Dmel_CG3619
    See related
    AllianceGenome:FB:FBgn0000463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0495/20; 0926/11; 1053/14; 1119/09; 1304/03; 1423/11; 1440/11; 1485/04; anon-WO0118547.269; C1; CG3619; CT12133; D1; delta; delta D1; Deltal; Dl; DL; dmDelta; Dmel\CG3619; E(ls)2; EC3-5; l(3)05151; l(3)92Ab; l(3)j8C3
    Summary
    Enables Notch binding activity; glycosphingolipid binding activity; and receptor ligand activity. Involved in several processes, including imaginal disc-derived appendage morphogenesis; neurogenesis; and oogenesis. Located in several cellular components, including apical cortex; cell surface; and cytoplasmic vesicle. Colocalizes with cytoplasmic vesicle. Is expressed in several structures, including epithelium; gut section; imaginal disc; photoreceptor neurons; and somatic precursor cell. Used to study cancer and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to several human genes including DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Delta in Genome Data Viewer
    Location:
    92A1-92A2; 3-66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19302731..19326217, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15128453..15151939, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43451 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44175 Neighboring gene hairpin RNA:CR46343 Neighboring gene long non-coding RNA:CR43258

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Notch binding  
    enables Notch binding PubMed 
    enables Notch binding PubMed 
    enables calcium ion binding  
    enables glycosphingolipid binding PubMed 
    enables protein binding PubMed 
    enables receptor ligand activity PubMed 
    Items 1 - 25 of 41
    Process Evidence Code Pubs
    involved_in Notch signaling pathway  
    involved_in Notch signaling pathway PubMed 
    involved_in Notch signaling pathway  
    involved_in Notch signaling pathway PubMed 
    involved_in Notch signaling pathway PubMed 
    involved_in R3/R4 cell differentiation PubMed 
    involved_in R7 cell differentiation PubMed 
    involved_in actin filament organization PubMed 
    involved_in antennal morphogenesis PubMed 
    involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces PubMed 
    involved_in asymmetric cell division PubMed 
    involved_in border follicle cell migration PubMed 
    involved_in cell communication  
    involved_in cell fate specification PubMed 
    involved_in chaeta morphogenesis PubMed 
    involved_in compound eye photoreceptor development PubMed 
    involved_in compound eye retinal cell programmed cell death PubMed 
    involved_in follicle cell of egg chamber development PubMed 
    involved_in follicle cell of egg chamber stalk formation PubMed 
    involved_in germ-line stem cell population maintenance PubMed 
    involved_in glial cell migration PubMed 
    involved_in imaginal disc-derived leg morphogenesis PubMed 
    involved_in imaginal disc-derived leg segmentation PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis PubMed 
    involved_in imaginal disc-derived wing morphogenesis PubMed 
    involved_in lateral inhibition PubMed 
    involved_in mesoderm development PubMed 
    involved_in negative regulation of Notch signaling pathway  
    involved_in neuroblast fate determination PubMed 
    involved_in neuron fate specification PubMed 
    involved_in oocyte localization involved in germarium-derived egg chamber formation PubMed 
    involved_in oogenesis PubMed 
    involved_in peripheral nervous system development PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of mitotic cell cycle PubMed 
    involved_in regulation of establishment of planar polarity PubMed 
    involved_in second mitotic wave involved in compound eye morphogenesis PubMed 
    involved_in sensory organ development PubMed 
    involved_in stem cell differentiation PubMed 
    involved_in wing disc anterior/posterior pattern formation PubMed 
    involved_in wing disc dorsal/ventral pattern formation PubMed 
    Items 1 - 25 of 41
    Component Evidence Code Pubs
    located_in apical cortex PubMed 
    located_in cell surface PubMed 
    colocalizes_with cytoplasmic vesicle PubMed 
    located_in cytoplasmic vesicle PubMed 
    located_in early endosome PubMed 
    located_in endocytic vesicle PubMed 
    located_in endosome PubMed 
    located_in membrane PubMed 
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    delta
    Names
    CG3619-PA
    CG3619-PB
    CG3619-PC
    Delta-PA
    Delta-PB
    Delta-PC
    complementation group 1
    overflow

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19302731..19326217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057916.4 → NP_477264.1  delta, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477264.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10041, Q6T3F7, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2
      UniProtKB/TrEMBL
      A4V346
      Related
      FBpp0083153
      Conserved Domains (3) summary
      cd00054
      Location:529 → 564
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01414
      Location:164 → 226
      DSL; Delta serrate ligand
      pfam07657
      Location:23 → 96
      MNNL; N terminus of Notch ligand
    2. NM_001260264.2 → NP_001247193.1  delta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247193.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10041, Q6T3F7, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2
      UniProtKB/TrEMBL
      A4V346
      Conserved Domains (3) summary
      cd00054
      Location:529 → 564
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01414
      Location:164 → 226
      DSL; Delta serrate ligand
      pfam07657
      Location:23 → 96
      MNNL; N terminus of Notch ligand
    3. NM_169853.3 → NP_732412.1  delta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732412.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10041, Q6T3F7, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2
      UniProtKB/TrEMBL
      A4V346
      Related
      FBpp0083154
      Conserved Domains (3) summary
      cd00054
      Location:529 → 564
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01414
      Location:164 → 226
      DSL; Delta serrate ligand
      pfam07657
      Location:23 → 96
      MNNL; N terminus of Notch ligand
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