U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    PFD1 prefolding complex chaperone subunit [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853260, updated on 9-Dec-2024

    Summary

    Official Symbol
    PFD1
    Official Full Name
    prefolding complex chaperone subunit
    Primary source
    SGD:S000003715
    Locus tag
    YJL179W
    See related
    AllianceGenome:SGD:S000003715; FungiDB:YJL179W; VEuPathDB:YJL179W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GIM6
    Summary
    Enables unfolded protein binding activity. Involved in cytoskeleton organization; positive regulation of transcription elongation by RNA polymerase II; and protein folding. Part of prefoldin complex. Orthologous to human PFDN1 (prefoldin subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PFD1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (88787..89116)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Rbh1p Neighboring gene ATP synthase complex assembly protein ATP12 Neighboring gene Atg27p Neighboring gene ribosomal 60S subunit protein L17B

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein folding chaperone  
    enables unfolded protein binding  
    enables unfolded protein binding  
    enables unfolded protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    part_of prefoldin complex  
    part_of prefoldin complex PubMed 

    General protein information

    Preferred Names
    prefolding complex chaperone subunit
    NP_012356.2
    • Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      88787..89116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181612.2 → NP_012356.2  TPA: prefolding complex chaperone subunit [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012356.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW10, E9P8V7, P46988
      UniProtKB/TrEMBL
      A6ZQF5, B3LPU6, C7GS05, C8ZB40, G2WGJ6, N1P8Z6
      Conserved Domains (1) summary
      cl09111
      Location:12 → 109
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    External link. Please review our privacy policy.