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    qkr58E-3 quaking related 58E-3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37559, updated on 9-Dec-2024

    Summary

    Official Symbol
    qkr58E-3provided by FlyBase
    Official Full Name
    quaking related 58E-3provided by FlyBase
    Primary source
    FLYBASE:FBgn0022984
    Locus tag
    Dmel_CG3584
    See related
    AllianceGenome:FB:FBgn0022984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3584; Dmel\CG3584; kep1; KEP1; qkr58e-3; QKR58E-3; qrk58E-3
    Summary
    Enables RNA binding activity. Involved in apoptotic process and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in follicle cell; nurse cell; and organism. Orthologous to human KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See qkr58E-3 in Genome Data Viewer
    Location:
    58D7-58D8; 2-99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22409208..22411545, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18296713..18299050, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44760 Neighboring gene uncharacterized protein Neighboring gene Ventrally-expressed protein D Neighboring gene DNA polymerase epsilon subunit 4 Neighboring gene quaking related 58E-1 Neighboring gene antisense RNA:CR45152 Neighboring gene quaking related 58E-2

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables RNA binding  
    enables RNA binding PubMed 
    enables mRNA binding  
    Component Evidence Code Pubs
    located_in nuclear speck PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    quaking related 58E-3
    Names
    CG3584-PB
    CG3584-PC
    CG3584-PD
    KH domain encompassing protein 1
    qkr58E-3-PB
    qkr58E-3-PC
    qkr58E-3-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22409208..22411545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299792.1 → NP_001286721.1  quaking related 58E-3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286721.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44434, Q9TZN6
      Conserved Domains (1) summary
      cd02395
      Location:81 → 200
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    2. NM_001259531.2 → NP_001246460.1  quaking related 58E-3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246460.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44434, Q9TZN6
      Conserved Domains (1) summary
      cd02395
      Location:81 → 200
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    3. NM_057958.5 → NP_477306.3  quaking related 58E-3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477306.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44434, Q9TZN6
      Conserved Domains (1) summary
      cd02395
      Location:81 → 200
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
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