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    TYW3 tRNA methyltransferase TYW3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852832, updated on 9-Dec-2024

    Summary

    Official Symbol
    TYW3
    Official Full Name
    tRNA methyltransferase TYW3
    Primary source
    SGD:S000003018
    Locus tag
    YGL050W
    See related
    AllianceGenome:SGD:S000003018; FungiDB:YGL050W; VEuPathDB:YGL050W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA methyltransferase activity. Involved in tRNA methylation and wybutosine biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human TYW3 (tRNA-yW synthesizing protein 3 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See TYW3 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (405776..406597)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene DUP240 family protein MST27 Neighboring gene tRNA-Arg Neighboring gene translation initiation factor eIF4G Neighboring gene proteasome regulatory particle base subunit RPT6

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in methylation  
    involved_in tRNA methylation  
    involved_in tRNA methylation PubMed 
    involved_in tRNA methylation PubMed 
    involved_in tRNA processing  
    involved_in wybutosine biosynthetic process  
    involved_in wybutosine biosynthetic process PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component  
    is_active_in cytoplasm  

    General protein information

    Preferred Names
    tRNA methyltransferase TYW3
    NP_011465.3
    • tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      405776..406597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180915.3 → NP_011465.3  TPA: tRNA methyltransferase TYW3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011465.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU90, P53177
      UniProtKB/TrEMBL
      B3LIQ9, B5VIR9, C7GS27, C8Z8J4, G2WE46, N1P386
      Conserved Domains (1) summary
      pfam02676
      Location:10 → 227
      TYW3; Methyltransferase TYW3
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