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    Ten-a Tenascin accessory [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32183, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ten-aprovided by FlyBase
    Official Full Name
    Tenascin accessoryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267001
    Locus tag
    Dmel_CG42338
    See related
    AllianceGenome:FB:FBgn0267001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1.2; cbd; CG11270; CG12720; CG15733; CG18182; CG2578; CG2590; CG32659; CG42338; Dmel\CG42338; Dmtena; DmtenA; ten-a; Ten11A; tenA; tenA(AT)[[14]]; ten[a]; Ten[a]
    Old locus tag
    Dmel_CG12720; Dmel_CG15733; Dmel_CG32659
    Summary
    Enables protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including nervous system development; regulation of cell-cell adhesion; and synapse organization. Located in several cellular components, including cytoskeleton of presynaptic active zone; neuromuscular junction; and presynaptic membrane. Is expressed in several structures, including adult olfactory antennal lobe glomerulus; anterior-posterior subdivision of organism; direct flight muscle precursor cell; neuron projection bundle of larval ventral nerve cord; and olfactory system neurons. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human TENM2 (teneurin transmembrane protein 2) and TENM3 (teneurin transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ten-a in Genome Data Viewer
    Location:
    11A2-11A8; 1-38 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12043698..12335214)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11937731..12229247)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43960 Neighboring gene Cytochrome P450 311a1 Neighboring gene Cytochrome P450 318a1 Neighboring gene long non-coding RNA:CR43961 Neighboring gene long non-coding RNA:CR32657 Neighboring gene Uch-L5-related Neighboring gene long non-coding RNA:CR32658 Neighboring gene Mucin 11A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene moonshiner Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 11a

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    mobile_element

    • Loc: 12163544-12163806 mobile_element_type = transposon:INE-1{}1864
    • Loc: 12168193-12173562 mobile_element_type = transposon:I{}112

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in central complex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of alignment of postsynaptic density and presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in maintenance of alignment of postsynaptic density and presynaptic active zone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of presynaptic active zone structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of heterotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynaptic membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of homotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic target attraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic target recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton of presynaptic active zone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tenascin accessory
    Names
    CG42338-PD
    CG42338-PE
    CG42338-PF
    CG42338-PG
    CG42338-PI
    CG42338-PK
    CG42338-PL
    CG42338-PM
    CG42338-PN
    CG42338-PO
    CG42338-PP
    Ten-a-PD
    Ten-a-PE
    Ten-a-PF
    Ten-a-PG
    Ten-a-PI
    Ten-a-PK
    Ten-a-PL
    Ten-a-PM
    Ten-a-PN
    Ten-a-PO
    Ten-a-PP
    Teneurin-a
    central body defect
    central-body-defect
    tenascin-like molecule accessory
    teneurin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12043698..12335214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169259.3NP_001162730.2  tenascin accessory, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162730.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z145, E1JJM3
      Conserved Domains (9) summary
      COG3209
      Location:23882949
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:11621192
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:16661712
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:29303006
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:9981162
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:22042241
      RHS_repeat; RHS Repeat
      pfam07974
      Location:10321057
      EGF_2; EGF-like domain
      pfam15636
      Location:32653340
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:16131918
      NHL; NHL repeat unit of beta-propeller proteins
    2. NM_001169261.3NP_001162732.2  tenascin accessory, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162732.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYN8
      Conserved Domains (9) summary
      COG3209
      Location:23972958
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:11631192
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:16751721
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:29393015
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:9981162
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:22132250
      RHS_repeat; RHS Repeat
      pfam07974
      Location:10321057
      EGF_2; EGF-like domain
      pfam15636
      Location:32743349
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:16221927
      NHL; NHL repeat unit of beta-propeller proteins
    3. NM_001169260.3NP_001162731.1  tenascin accessory, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162731.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24550, Q9VYN8
      UniProtKB/TrEMBL
      M9PJK5
      Conserved Domains (9) summary
      COG3209
      Location:20142575
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:789818
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:12921338
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25562632
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:624788
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:18301867
      RHS_repeat; RHS Repeat
      pfam07974
      Location:658683
      EGF_2; EGF-like domain
      pfam15636
      Location:28912966
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:12391544
      NHL; NHL repeat unit of beta-propeller proteins
    4. NM_001144718.3NP_001138190.1  tenascin accessory, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138190.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24550, Q9VYN8
      UniProtKB/TrEMBL
      M9PJK5
      Conserved Domains (9) summary
      COG3209
      Location:20142575
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:789818
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:12921338
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25562632
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:624788
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:18301867
      RHS_repeat; RHS Repeat
      pfam07974
      Location:658683
      EGF_2; EGF-like domain
      pfam15636
      Location:28912966
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:12391544
      NHL; NHL repeat unit of beta-propeller proteins
    5. NM_001144717.4NP_001138189.1  tenascin accessory, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z145, E1JJM3
      Conserved Domains (9) summary
      COG3209
      Location:23882949
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:11621192
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:16661712
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:29303006
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:9981162
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:22042241
      RHS_repeat; RHS Repeat
      pfam07974
      Location:10321057
      EGF_2; EGF-like domain
      pfam15636
      Location:32653340
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:16131918
      NHL; NHL repeat unit of beta-propeller proteins
    6. NM_001272554.2NP_001259483.1  tenascin accessory, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259483.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24550, Q9VYN8
      UniProtKB/TrEMBL
      M9PJK5
      Conserved Domains (9) summary
      COG3209
      Location:20142575
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:789818
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:12921338
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25562632
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:624788
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:18301867
      RHS_repeat; RHS Repeat
      pfam07974
      Location:658683
      EGF_2; EGF-like domain
      pfam15636
      Location:28912966
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:12391544
      NHL; NHL repeat unit of beta-propeller proteins
    7. NM_001258713.2NP_001245642.1  tenascin accessory, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245642.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF26
      Conserved Domains (9) summary
      COG3209
      Location:20232584
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:789818
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:13011347
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25652641
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:624788
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:18391876
      RHS_repeat; RHS Repeat
      pfam07974
      Location:658683
      EGF_2; EGF-like domain
      pfam15636
      Location:29002975
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:12481553
      NHL; NHL repeat unit of beta-propeller proteins
    8. NM_001258712.2NP_001245641.1  tenascin accessory, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF26
      Conserved Domains (9) summary
      COG3209
      Location:20232584
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:789818
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:13011347
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25652641
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:624788
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:18391876
      RHS_repeat; RHS Repeat
      pfam07974
      Location:658683
      EGF_2; EGF-like domain
      pfam15636
      Location:29002975
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:12481553
      NHL; NHL repeat unit of beta-propeller proteins
    9. NM_001258711.2NP_001245640.1  tenascin accessory, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24550, Q9VYN8
      UniProtKB/TrEMBL
      M9PJK5
      Conserved Domains (9) summary
      COG3209
      Location:20142575
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:789818
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:12921338
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25562632
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:624788
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:18301867
      RHS_repeat; RHS Repeat
      pfam07974
      Location:658683
      EGF_2; EGF-like domain
      pfam15636
      Location:28912966
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:12391544
      NHL; NHL repeat unit of beta-propeller proteins
    10. NM_001169258.2NP_001162729.1  tenascin accessory, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162729.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJM6
      Conserved Domains (9) summary
      COG3209
      Location:19122473
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:687716
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:11901236
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24542530
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:522686
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:17281765
      RHS_repeat; RHS Repeat
      pfam07974
      Location:556581
      EGF_2; EGF-like domain
      pfam15636
      Location:27892864
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:11371442
      NHL; NHL repeat unit of beta-propeller proteins
    11. NM_078582.4NP_511137.3  tenascin accessory, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511137.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24550, Q9VYN8
      UniProtKB/TrEMBL
      M9PJK5
      Related
      FBpp0289136
      Conserved Domains (9) summary
      COG3209
      Location:20142575
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:789818
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:12921338
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25562632
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:624788
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:18301867
      RHS_repeat; RHS Repeat
      pfam07974
      Location:658683
      EGF_2; EGF-like domain
      pfam15636
      Location:28912966
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:12391544
      NHL; NHL repeat unit of beta-propeller proteins