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    wds will die slowly [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53428, updated on 17-Dec-2024

    Summary

    Official Symbol
    wdsprovided by FlyBase
    Official Full Name
    will die slowlyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040066
    Locus tag
    Dmel_CG17437
    See related
    AllianceGenome:FB:FBgn0040066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17437; Dmel\CG17437; dWds; EG:BACR25B3.7; l(1)16-94; l(1)3Ad; l(1)G0251; l(1)zw8; WD5; WDR5; Wds; WDS; zw-8; zw8
    Summary
    Predicted to enable histone binding activity. Involved in several processes, including chromatin remodeling; haltere development; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleus. Part of histone acetyltransferase complex and histone methyltransferase complex. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; ganglia; gut section; and larval muscle system. Used to study congenital heart disease. Orthologous to several human genes including WDR5 (WD repeat domain 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See wds in Genome Data Viewer
    Location:
    3A6-3A6; 1-1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2585980..2588217)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2480013..2482250)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase 36kD subunit 3 Neighboring gene Arylalkylamine N-acetyltransferase-like 7 Neighboring gene uncharacterized protein Neighboring gene egghead Neighboring gene Kinesin-like protein at 3A

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of ATAC complex PubMed 
    part_of ATAC complex PubMed 
    part_of MLL1/2 complex PubMed 
    part_of MLL3/4 complex PubMed 
    part_of NSL complex PubMed 
    part_of Set1C/COMPASS complex  
    part_of Set1C/COMPASS complex PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    will die slowly
    Names
    CG17437-PA
    CG17437-PB
    lethal(1)3Ad
    wds-PA
    wds-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2585980..2588217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258574.2 → NP_001245503.1  will die slowly, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245503.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3J8
      UniProtKB/TrEMBL
      M9NDM4
      Conserved Domains (2) summary
      cd00200
      Location:64 → 358
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:75 → 112
      7WD40; WD40 repeat [structural motif]
    2. NM_080245.5 → NP_524984.1  will die slowly, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524984.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3J8
      UniProtKB/TrEMBL
      M9NDM4
      Related
      FBpp0070422
      Conserved Domains (2) summary
      cd00200
      Location:64 → 358
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:75 → 112
      7WD40; WD40 repeat [structural motif]
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