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    HDA1 histone deacetylase HDA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855710, updated on 9-Dec-2024

    Summary

    Official Symbol
    HDA1
    Official Full Name
    histone deacetylase HDA1
    Primary source
    SGD:S000004966
    Locus tag
    YNL021W
    See related
    AllianceGenome:SGD:S000004966; FungiDB:YNL021W; VEuPathDB:YNL021W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chromatin binding activity. Contributes to histone deacetylase activity. Involved in negative regulation of transcription by RNA polymerase II; negative regulation of transcription by transcription factor localization; and positive regulation of transcription by RNA polymerase II. Part of HDA1 complex. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to several human genes including HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See HDA1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (593227..595347)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Fap1p Neighboring gene rRNA (cytosine-C5-)-methyltransferase RCM1 Neighboring gene serine/threonine protein kinase ARK1 Neighboring gene uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    part_of HDA1 complex PubMed 
    part_of HDA1 complex PubMed 
    part_of histone deacetylase complex  
    located_in nucleus  

    General protein information

    Preferred Names
    histone deacetylase HDA1
    NP_014377.1
    • Catalytic subunit of class II HDA1 histone deacetylase complex; role in azole resistance via Hsp90p, and in heat shock response; Hda1p interacts with Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; the HDA1 histone deacetylase complex regulates aging through trehalose metabolism

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      593227..595347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182860.1NP_014377.1  TPA: histone deacetylase HDA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014377.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1F8, P53973
      UniProtKB/TrEMBL
      A6ZS47, B3LNP4, C7GWN8, C8ZFJ7, G2WM72, N1NWQ4
      Conserved Domains (2) summary
      cd11600
      Location:81403
      HDAC_Clr3; Class II Histone deacetylase Clr3 and similar proteins
      pfam09757
      Location:457698
      Arb2; Arb2 domain
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