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    WRS1 tryptophan--tRNA ligase WRS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854056, updated on 9-Dec-2024

    Summary

    Official Symbol
    WRS1
    Official Full Name
    tryptophan--tRNA ligase WRS1
    Primary source
    SGD:S000005457
    Locus tag
    YOL097C
    See related
    AllianceGenome:SGD:S000005457; FungiDB:YOL097C; VEuPathDB:YOL097C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HRE342
    Summary
    Enables sequence-specific mRNA binding activity and tryptophan-tRNA ligase activity. Predicted to be involved in tryptophanyl-tRNA aminoacylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See WRS1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (136527..137825, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene hexaprenyldihydroxybenzoate methyltransferase Neighboring gene ATP-dependent 3'-5' DNA helicase

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables aminoacyl-tRNA ligase activity  
    enables sequence-specific mRNA binding PubMed 
    enables tryptophan-tRNA ligase activity  
    enables tryptophan-tRNA ligase activity PubMed 
    enables tryptophan-tRNA ligase activity  
    Process Evidence Code Pubs
    involved_in translation  
    involved_in tryptophanyl-tRNA aminoacylation  
    involved_in tryptophanyl-tRNA aminoacylation  
    involved_in tryptophanyl-tRNA aminoacylation PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  

    General protein information

    Preferred Names
    tryptophan--tRNA ligase WRS1
    NP_014544.1
    • Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      136527..137825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183351.1 → NP_014544.1  TPA: tryptophan--tRNA ligase WRS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1X1, E9P8Z9, Q12109
      UniProtKB/TrEMBL
      A6ZNB3, B3LIW6, B5VRF8, C8ZHL8, G2WMD8, N1NX56
      Conserved Domains (1) summary
      cl00015
      Location:25 → 409
      nt_trans; nucleotidyl transferase superfamily
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