Replication interactions
Interaction |
Pubs |
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of IPO5 |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Rev
|
rev
|
importin beta specifically binds to the Rev nuclear localization signal (NLS, amino acids 35-50) and mediates the nuclear import of Rev |
PubMed
|
|
rev
|
importin beta can inhibit the interaction of HIV-1 Rev with HIV-1 RRE RNA |
PubMed
|
Tat
|
tat
|
The binding of HIV-1 Tat with importin beta is inhibited by RanGTP |
PubMed
|
|
tat
|
Importin beta binds to the HIV-1 Tat protein nuclear localization signal (NLS; amino acids 49-57) and mediates the nuclear import of Tat through a novel import pathway |
PubMed
|
Vpr
|
vpr
|
HIV-1 Vpr causes increased levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin beta |
PubMed
|
|
vpr
|
HIV-1 Vpr co-localizes with karyopherin beta and regulates karyopherin beta-mediated docking of the HIV-1 preintegration complex at the nuclear envelope, however multiple reports indicate the two proteins do not directly interact |
PubMed
|
capsid
|
gag
|
The interaction of HIV-1 CA with human cellular importin 5 protein (IPO5) is identified by yeast two-hybrid screen |
PubMed
|
integrase
|
gag-pol
|
Some reports indicate a possible role for the interactions between karyopherin alpha and beta with HIV-1 integrase in the nuclear import of HIV-1 preintegration complexes (PIC), while other reports indicate integrase is not involved in PIC nuclear import |
PubMed
|
|
gag-pol
|
Karyopherin beta binds to complexes between HIV-1 integrase (integrase/GST fusion protein) and karyopherin alpha, but not to integrase alone |
PubMed
|
|
gag-pol
|
Karyopherin alpha and beta are reported to interact with HIV-1 integrase (IN) to facilitate nuclear import of IN, however a conflicting report indicates nuclear accumulation of IN does not involve karyopherin alpha, beta 1, or beta 2 mediated pathways |
PubMed
|
matrix
|
gag
|
Karyopherin beta mediates the nuclear import of HIV-1 preintegration complexes through karyopherin alpha, which binds directly to nuclear localization signals in HIV-1 Matrix |
PubMed
|
Go to the HIV-1, Human Interaction Database