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    prkl-1 LIM zinc-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177463, updated on 9-Dec-2024

    Summary

    Official Symbol
    prkl-1
    Official Full Name
    LIM zinc-binding domain-containing protein
    Primary source
    WormBase:WBGene00022727
    Locus tag
    CELE_ZK381.5
    See related
    AllianceGenome:WB:WBGene00022727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable zinc ion binding activity. Is expressed in several structures, including QL; egg-laying apparatus; gonad; head; and somatic nervous system. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to several human genes including PRICKLE2 (prickle planar cell polarity protein 2) and PRICKLE3 (prickle planar cell polarity protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See prkl-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (6978742..6986935, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Guanyl-specific ribonuclease pgl-1 Neighboring gene HORMA domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding  
    enables zinc ion binding  

    General protein information

    Preferred Names
    LIM zinc-binding domain-containing protein
    NP_741435.2
    • Confirmed by transcript evidence
    NP_741436.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6978742..6986935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171372.3NP_741435.2  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741435.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYA1
      Conserved Domains (4) summary
      cd09340
      Location:149204
      LIM1_Testin_like; The first LIM domain of Testin-like family
      cd09341
      Location:210262
      LIM2_Testin_like; The second LIM domain of Testin-like family
      cd09827
      Location:48144
      PET_Prickle; The PET domain of Prickle
      cl02475
      Location:283324
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    2. NM_171373.6NP_741436.2  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741436.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WFL0
      Conserved Domains (3) summary
      cd09340
      Location:3690
      LIM1_Testin_like; The first LIM domain of Testin-like family
      cd09341
      Location:96148
      LIM2_Testin_like; The second LIM domain of Testin-like family
      cl02475
      Location:169210
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
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