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Childhood Malignant Central Nervous System Neoplasm

MedGen UID:
233149
Concept ID:
C1334573
Neoplastic Process
Synonyms: Childhood Malignant Central Nervous System Neoplasms; Childhood Malignant Central Nervous System Tumors; Malignant Central Nervous System Neoplasms of Childhood; Malignant Central Nervous System Tumors of Childhood; Malignant Childhood Central Nervous System Neoplasms; Malignant Childhood Central Nervous System Tumor; Malignant Childhood Central Nervous System Tumors; Malignant Childhood CNS Neoplasm; Malignant Childhood CNS Tumor; Malignant Childhood Neoplasm of Central Nervous System; Malignant Childhood Neoplasm of CNS; Malignant Childhood Neoplasm of the Central Nervous System; Malignant Childhood Neoplasm of the CNS; Malignant Childhood Tumor of Central Nervous System; Malignant Childhood Tumor of CNS; Malignant Childhood Tumor of the Central Nervous System; Malignant Childhood Tumor of the CNS; Malignant Pediatric Central Nervous System Neoplasm; Malignant Pediatric Central Nervous System Tumor; Malignant Pediatric CNS Neoplasm; Malignant Pediatric CNS Tumor; Malignant Pediatric Neoplasm of Central Nervous System; Malignant Pediatric Neoplasm of CNS; Malignant Pediatric Neoplasm of the Central Nervous System; Malignant Pediatric Neoplasm of the CNS; Malignant Pediatric Tumor of Central Nervous System; Malignant Pediatric Tumor of CNS; Malignant Pediatric Tumor of the Central Nervous System; Malignant Pediatric Tumor of the CNS

Definition

A primary or metastatic malignant neoplasm that affects the central nervous system and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Malignant Central Nervous System Neoplasm

Professional guidelines

PubMed

Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Le Rhun E, Guckenberger M, Smits M, Dummer R, Bachelot T, Sahm F, Galldiks N, de Azambuja E, Berghoff AS, Metellus P, Peters S, Hong YK, Winkler F, Schadendorf D, van den Bent M, Seoane J, Stahel R, Minniti G, Wesseling P, Weller M, Preusser M; EANO Executive Board and ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2021 Nov;32(11):1332-1347. Epub 2021 Aug 6 doi: 10.1016/j.annonc.2021.07.016. PMID: 34364998
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Recent clinical studies

Etiology

Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Ostrom QT, Francis SS, Barnholtz-Sloan JS
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):68. doi: 10.1007/s11910-021-01152-9. PMID: 34817716Free PMC Article
Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, Fuchs HE, Waite KA, Jemal A, Siegel RL, Barnholtz-Sloan JS
CA Cancer J Clin 2021 Sep;71(5):381-406. Epub 2021 Aug 24 doi: 10.3322/caac.21693. PMID: 34427324
Umansky F, Shoshan Y, Rosenthal G, Fraifeld S, Spektor S
Neurosurg Focus 2008;24(5):E7. doi: 10.3171/FOC/2008/24/5/E7. PMID: 18447746
Pizer B, May P
Eur J Surg Oncol 1997 Dec;23(6):559-64. doi: 10.1016/s0748-7983(97)93269-8. PMID: 9484930

Diagnosis

Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, Fuchs HE, Waite KA, Jemal A, Siegel RL, Barnholtz-Sloan JS
CA Cancer J Clin 2021 Sep;71(5):381-406. Epub 2021 Aug 24 doi: 10.3322/caac.21693. PMID: 34427324
Malbari F
Neurol Clin 2021 Aug;39(3):829-845. Epub 2021 Jun 10 doi: 10.1016/j.ncl.2021.04.005. PMID: 34215389
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW
Neuro Oncol 2021 Aug 2;23(8):1231-1251. doi: 10.1093/neuonc/noab106. PMID: 34185076Free PMC Article
Udaka YT, Packer RJ
Neurol Clin 2018 Aug;36(3):533-556. doi: 10.1016/j.ncl.2018.04.009. PMID: 30072070

Therapy

Vitanza NA, Wilson AL, Huang W, Seidel K, Brown C, Gustafson JA, Yokoyama JK, Johnson AJ, Baxter BA, Koning RW, Reid AN, Meechan M, Biery MC, Myers C, Rawlings-Rhea SD, Albert CM, Browd SR, Hauptman JS, Lee A, Ojemann JG, Berens ME, Dun MD, Foster JB, Crotty EE, Leary SES, Cole BL, Perez FA, Wright JN, Orentas RJ, Chour T, Newell EW, Whiteaker JR, Zhao L, Paulovich AG, Pinto N, Gust J, Gardner RA, Jensen MC, Park JR
Cancer Discov 2023 Jan 9;13(1):114-131. doi: 10.1158/2159-8290.CD-22-0750. PMID: 36259971Free PMC Article
Lieberman NA, Moyes KW, Crane CA
Expert Rev Anticancer Ther 2016 Jul;16(7):775-88. Epub 2016 Jun 13 doi: 10.1080/14737140.2016.1192470. PMID: 27253692
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Umansky F, Shoshan Y, Rosenthal G, Fraifeld S, Spektor S
Neurosurg Focus 2008;24(5):E7. doi: 10.3171/FOC/2008/24/5/E7. PMID: 18447746
Mazewski CM, Hudgins RJ, Reisner A, Geyer JR
Semin Perinatol 1999 Aug;23(4):286-98. doi: 10.1016/s0146-0005(99)80037-8. PMID: 10475542

Prognosis

Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Ostrom QT, Francis SS, Barnholtz-Sloan JS
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):68. doi: 10.1007/s11910-021-01152-9. PMID: 34817716Free PMC Article
Le Rhun E, Guckenberger M, Smits M, Dummer R, Bachelot T, Sahm F, Galldiks N, de Azambuja E, Berghoff AS, Metellus P, Peters S, Hong YK, Winkler F, Schadendorf D, van den Bent M, Seoane J, Stahel R, Minniti G, Wesseling P, Weller M, Preusser M; EANO Executive Board and ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2021 Nov;32(11):1332-1347. Epub 2021 Aug 6 doi: 10.1016/j.annonc.2021.07.016. PMID: 34364998
Malbari F
Neurol Clin 2021 Aug;39(3):829-845. Epub 2021 Jun 10 doi: 10.1016/j.ncl.2021.04.005. PMID: 34215389
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Clinical prediction guides

Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M
Cell 2024 Sep 5;187(18):4926-4945.e22. Epub 2024 Jul 9 doi: 10.1016/j.cell.2024.06.023. PMID: 38986619
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Recent systematic reviews

Ajithkumar T, Avanzo M, Yorke E, Tsang DS, Milano MT, Olch AJ, Merchant TE, Dieckmann K, Mahajan A, Fuji H, Paulino AC, Timmermann B, Marks LB, Bentzen SM, Jackson A, Constine LS
Int J Radiat Oncol Biol Phys 2024 Jun 1;119(2):655-668. Epub 2024 Feb 1 doi: 10.1016/j.ijrobp.2023.12.043. PMID: 38300187
Onyije FM, Dolatkhah R, Olsson A, Bouaoun L, Deltour I, Erdmann F, Bonaventure A, Scheurer ME, Clavel J, Schüz J
Cancer Epidemiol 2024 Feb;88:102510. Epub 2023 Dec 5 doi: 10.1016/j.canep.2023.102510. PMID: 38056243Free PMC Article
Jamshidi AM, Soldozy S, Elarjani T, Burks JD, Luther E, Starke RM
World Neurosurg 2022 Jun;162:77-84. Epub 2021 Sep 20 doi: 10.1016/j.wneu.2021.09.058. PMID: 34555575
Richards S, Pui CH, Gayon P; Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG)
Pediatr Blood Cancer 2013 Feb;60(2):185-95. Epub 2012 Jun 12 doi: 10.1002/pbc.24228. PMID: 22693038Free PMC Article
Raghuram CP, Moreno L, Zacharoulis S
J Neurooncol 2012 Feb;106(3):441-7. Epub 2011 Aug 18 doi: 10.1007/s11060-011-0690-6. PMID: 21850536

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