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Myocardial disorder

MedGen UID:: 469033
•Concept ID:: C3241958
•: Disease or Syndrome

Synonyms:	disease of myocardium; disease or disorder of myocardium; disorder of heart muscle; disorder of myocardium; myocardial disease; Myocardial Disorder; myocardial disorder; myocardium disease; myocardium disease or disorder

Monarch Initiative:	MONDO:0024643

Definition

A disorder that affects the muscle tissue of the heart. Representative examples include myocardial infarction, myocarditis, and cardiomyopathy. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMyocardial disorder

Pathological process
- Disease
  - Disorder by Site
    - Disorder of cardiovascular system
      - Heart disease
        Non-Neoplastic Heart Disorder
        Myocardial disorder
        Acute coronary syndrome
        Myocardial infarction
        Acute myocardial infarction
        Anterior Wall Myocardial Infarction
        Cardiogenic shock
        Inferior myocardial infarction
        Myocardial infarction with non-obstructive coronary artery
        Non ST Elevated Myocardial Infarction
        Old myocardial infarction
        Silent myocardial infarction
        ST Segment Elevation Myocardial Infarction
        Cardiomyopathy
        Alcoholic cardiomyopathy
        Arrhythmia-Induced Cardiomyopathy
        Arrhythmogenic right ventricular cardiomyopathy
        Arrhythmogenic right ventricular dysplasia 1
        Arrhythmogenic right ventricular dysplasia 2
        Arrhythmogenic right ventricular dysplasia 3
        Arrhythmogenic right ventricular dysplasia 4
        Arrhythmogenic right ventricular dysplasia 5
        Arrhythmogenic right ventricular dysplasia 6
        Arrhythmogenic right ventricular dysplasia 8
        Arrhythmogenic right ventricular dysplasia 9
        Arrhythmogenic right ventricular dysplasia 10
        Arrhythmogenic right ventricular dysplasia 11
        Arrhythmogenic right ventricular dysplasia 12
        Arrhythmogenic right ventricular dysplasia 13
        Arrhythmogenic right ventricular dysplasia, familial, 7
        Familial isolated arrhythmogenic right ventricular dysplasia
        Naxos disease
        Atrial cardiomyopathy
        Chagas cardiomyopathy
        Danon disease
        Diabetic cardiomyopathy
        Endocardial fibroelastosis
        Isolated Noncompaction of the Ventricular Myocardium
        Endomyocardial fibrosis
        Histiocytoid cardiomyopathy
        Hypertrophic cardiomyopathy
        Apical hypertrophic cardiomyopathy
        Asymmetric septal hypertrophy
        Concentric hypertrophic cardiomyopathy
        Primary familial hypertrophic cardiomyopathy
        Idiopathic cardiomyopathy
        Idiopathic giant cell myocarditis
        Kearns-Sayre syndrome
        Myocardial Reperfusion Injury
        Myocarditis
        Acute myocarditis
        Bacterial myocarditis
        Immune Checkpoint Inhibitor-related Myocarditis
        Interstitial myocarditis
        Viral myocarditis
        Noncompaction cardiomyopathy
        Biventricular noncompaction cardiomyopathy
        Left ventricular noncompaction cardiomyopathy
        Right ventricular noncompaction cardiomyopathy
        Peripartum cardiomyopathy
        Primary dilated cardiomyopathy
        Dilated cardiomyopathy 1A
        Dilated cardiomyopathy 1C
        Dilated cardiomyopathy 1DD
        Dilated cardiomyopathy 1P
        Primary familial dilated cardiomyopathy
        Restrictive cardiomyopathy
        Sarcoglycanopathy
        Autosomal recessive limb-girdle muscular dystrophy type 2C
        Autosomal recessive limb-girdle muscular dystrophy type 2D
        Qualitative or quantitative defects of beta-sarcoglycan
        Qualitative or quantitative defects of delta-sarcoglycan
        Takotsubo cardiomyopathy
        Transthyretin Amyloid Cardiomyopathy
        Hereditary Transthyretin Amyloid Cardiomyopathy
        Myocardial degeneration

Professional guidelines

PubMed

Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases.

Seferović PM, Paulus WJ, Rosano G, Polovina M, Petrie MC, Jhund PS, Tschöpe C, Sattar N, Piepoli M, Papp Z, Standl E, Mamas MA, Valensi P, Linhart A, Lalić N, Ceriello A, Döhner W, Ristić A, Milinković I, Seferović J, Cosentino F, Metra M, Coats AJS
Eur J Heart Fail 2024 Sep;26(9):1893-1903. Epub 2024 Jun 19 doi: 10.1002/ejhf.3347. PMID: 38896048

Guidelines for the diagnosis and management of familial dilated cardiomyopathy.

Fatkin D; members of the CSANZ Cardiac Genetic Diseases Council Writing Group
Heart Lung Circ 2011 Nov;20(11):691-3. Epub 2011 Aug 31 doi: 10.1016/j.hlc.2011.07.008. PMID: 21885340

Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy.

Wang L, Seidman JG, Seidman CE
Ann Intern Med 2010 Apr 20;152(8):513-20, W181. doi: 10.7326/0003-4819-152-8-201004200-00008. PMID: 20404382 Free PMC Article

See all (6)

Recent clinical studies

Etiology

Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases.

A systematic review and meta-analysis of the efficacy and safety of Mavacamten therapy in international cohort of 524 patients with hypertrophic cardiomyopathy.

Yacoub MS, El-Nakhal T, Hasabo EA, Shehata N, Wilson K, Ismail KH, Bakr MS, Mohsen M, Mohamed A, Abdelazim E, Ali HT, Soliman Z, Sayed A, Abdelsayed K, Caliskan K, Soliman O
Heart Fail Rev 2024 Mar;29(2):479-496. Epub 2023 Dec 19 doi: 10.1007/s10741-023-10375-6. PMID: 38112937

Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients.

Nag S, Gollapudi SK, Del Rio CL, Spudich JA, McDowell R
Sci Adv 2023 Jul 28;9(30):eabo7622. doi: 10.1126/sciadv.abo7622. PMID: 37506209

Hypertrophic Cardiomyopathy: New Concepts and Therapies.

Maron BJ, Rowin EJ, Maron MS
Annu Rev Med 2022 Jan 27;73:363-375. doi: 10.1146/annurev-med-042220-021539. PMID: 35084989

Isolated left ventricular non-compaction: the case for abnormal myocardial development.

Breckenridge RA, Anderson RH, Elliott PM
Cardiol Young 2007 Apr;17(2):124-9. Epub 2007 Feb 26 doi: 10.1017/S1047951107000273. PMID: 17319979

See all (40)

Diagnosis

Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases.

Impaired calcium handling and mitochondrial metabolic dysfunction as early markers of hypertrophic cardiomyopathy.

Viola HM, Hool LC
Arch Biochem Biophys 2019 Apr 15;665:166-174. Epub 2019 Mar 16 doi: 10.1016/j.abb.2019.03.006. PMID: 30885674

Recent advancements in the molecular genetics of left ventricular noncompaction cardiomyopathy.

Dong X, Fan P, Tian T, Yang Y, Xiao Y, Yang K, Liu Y, Zhou X
Clin Chim Acta 2017 Feb;465:40-44. Epub 2016 Dec 15 doi: 10.1016/j.cca.2016.12.013. PMID: 27989498

Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy.

Asimaki A, Saffitz JE
Cell Commun Adhes 2014 Feb;21(1):13-23. doi: 10.3109/15419061.2013.876016. PMID: 24460198 Free PMC Article

Genetics of dilated cardiomyopathy.

Fatkin D, Otway R, Richmond Z
Heart Fail Clin 2010 Apr;6(2):129-40. doi: 10.1016/j.hfc.2009.11.003. PMID: 20347783

See all (60)

Therapy

Biomechanical response of ultrathin slices of hypertrophic cardiomyopathy tissue to myosin modulator mavacamten.

Amesz JH, Langmuur SJJ, Zhang L, Manintveld OC, Schinkel AFL, de Jong PL, de Groot NMS, Taverne YJHJ
Biomed Pharmacother 2024 Jan;170:116036. Epub 2023 Dec 21 doi: 10.1016/j.biopha.2023.116036. PMID: 38134635

A systematic review and meta-analysis of the efficacy and safety of Mavacamten therapy in international cohort of 524 patients with hypertrophic cardiomyopathy.

Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients.

Nag S, Gollapudi SK, Del Rio CL, Spudich JA, McDowell R
Sci Adv 2023 Jul 28;9(30):eabo7622. doi: 10.1126/sciadv.abo7622. PMID: 37506209

New treatment strategies for hypertrophic obstructive cardiomyopathy: alcohol ablation of the septum: the new gold standard?

Hess OM, Sigwart U
J Am Coll Cardiol 2004 Nov 16;44(10):2054-5. doi: 10.1016/j.jacc.2004.08.047. PMID: 15542291

A case of successful six consecutive deliveries in a 41-year-old woman with Uhl's anomaly.

Güler N, Demirbag R, Eryonucu B, Gül A
Int J Cardiol 2003 Feb;87(2-3):283-5. doi: 10.1016/s0167-5273(02)00306-6. PMID: 12559552

See all (14)

Prognosis

An Overview of Diabetic Cardiomyopathy.

Quaiyoom A, Kumar R
Curr Diabetes Rev 2024;20(5):e121023222139. doi: 10.2174/0115733998255538231001122639. PMID: 37842898

Prognosis and subtype analysis of left ventricular noncompaction in adults: A retrospective multicenter study.

Feng Y, Ning L, Zhang J, Wang H, Zhang H, Zhang R, Deng Z, Ni Y, Ye Y, Ma A, Zhang Y, Wang T
Clin Cardiol 2023 Apr;46(4):390-396. Epub 2023 Feb 13 doi: 10.1002/clc.23991. PMID: 36779545 Free PMC Article

When rare illuminates common: how cardiocutaneous syndromes transformed our perspective on arrhythmogenic cardiomyopathy.

Sen-Chowdhry S, McKenna WJ
Cell Commun Adhes 2014 Feb;21(1):3-11. doi: 10.3109/15419061.2013.876415. PMID: 24460197

Isolated left ventricular noncompaction: what do we really know?

Peters F, Khandheria BK
Curr Cardiol Rep 2012 Jun;14(3):381-8. doi: 10.1007/s11886-012-0255-0. PMID: 22415394

Risk stratification in hypertrophic cardiomyopathy.

Vassalli G, Seiler C, Hess OM
Curr Opin Cardiol 1994 May;9(3):330-6. doi: 10.1097/00001573-199405000-00011. PMID: 8049590

See all (28)

Clinical prediction guides

A systematic review and meta-analysis of the efficacy and safety of Mavacamten therapy in international cohort of 524 patients with hypertrophic cardiomyopathy.

An Overview of Diabetic Cardiomyopathy.

Quaiyoom A, Kumar R
Curr Diabetes Rev 2024;20(5):e121023222139. doi: 10.2174/0115733998255538231001122639. PMID: 37842898

Impaired calcium handling and mitochondrial metabolic dysfunction as early markers of hypertrophic cardiomyopathy.

Viola HM, Hool LC
Arch Biochem Biophys 2019 Apr 15;665:166-174. Epub 2019 Mar 16 doi: 10.1016/j.abb.2019.03.006. PMID: 30885674

Nomenclature and systems of classification for cardiomyopathy in children.

Konta L, Franklin RC, Kaski JP
Cardiol Young 2015 Aug;25 Suppl 2:31-42. doi: 10.1017/S1047951115001201. PMID: 26377708

Genetics of restrictive cardiomyopathy.

Sen-Chowdhry S, Syrris P, McKenna WJ
Heart Fail Clin 2010 Apr;6(2):179-86. doi: 10.1016/j.hfc.2009.11.005. PMID: 20347786

See all (28)

Recent systematic reviews

A systematic review and meta-analysis of the efficacy and safety of Mavacamten therapy in international cohort of 524 patients with hypertrophic cardiomyopathy.

See all (1)

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Myocardial disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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