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Benign Liver Epithelial Neoplasm

MedGen UID:: 474640
•Concept ID:: C3273007
•: Neoplastic Process

Synonym:

Benign Liver and Intrahepatic Bile Duct Epithelial Neoplasm

Definition

A neoplasm that arises from the hepatocytes or intrahepatic bile duct epithelial cells and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hepatocellular adenoma and bile duct adenoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign Liver Epithelial Neoplasm

Disorder of digestive system
- Disease of liver
  - Liver and intrahepatic bile duct neoplasm
    - Liver Epithelial Neoplasm
      - Benign Liver Epithelial Neoplasm
        Biliary Adenofibroma
        Hepatocellular adenoma
        Beta-Catenin-Activated Hepatocellular Adenoma
        HNF1alpha-Inactivated Hepatocellular Adenoma
        Inflammatory Hepatocellular Adenoma
        Beta-Catenin-Activated Inflammatory Hepatocellular Adenoma
        Unclassified Hepatocellular Adenoma
        Intrahepatic bile duct adenoma
        Intrahepatic Bile Duct Microcystic Adenoma

Professional guidelines

PubMed

Benign liver tumours: understanding molecular physiology to adapt clinical management.

Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851

Focal Nodular Hyperplasia and Hepatic Adenoma: Evaluation and Management.

Myers L, Ahn J
Clin Liver Dis 2020 Aug;24(3):389-403. Epub 2020 Jun 3 doi: 10.1016/j.cld.2020.04.013. PMID: 32620279

ACG clinical guideline: the diagnosis and management of focal liver lesions.

Marrero JA, Ahn J, Rajender Reddy K; Americal College of Gastroenterology
Am J Gastroenterol 2014 Sep;109(9):1328-47; quiz 1348. Epub 2014 Aug 19 doi: 10.1038/ajg.2014.213. PMID: 25135008

See all (178)

Recent clinical studies

Etiology

Biliary papillomatosis.

Gelders F, Struyve M, van Malenstein H
Acta Gastroenterol Belg 2023 Jul-Sep;86(3):483-485. doi: 10.51821/86.3.11733. PMID: 37814564

Benign liver tumours: understanding molecular physiology to adapt clinical management.

Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851

Hepatocellular adenoma: Where are we now?

Wang X, Zhang X
World J Gastroenterol 2022 Apr 14;28(14):1384-1393. doi: 10.3748/wjg.v28.i14.1384. PMID: 35582672 Free PMC Article

Imaging of Intrahepatic Cholangiocarcinoma.

Mar WA, Chan HK, Trivedi SB, Berggruen SM
Semin Ultrasound CT MR 2021 Aug;42(4):366-380. Epub 2021 Apr 20 doi: 10.1053/j.sult.2021.04.001. PMID: 34130849

LI-RADS(®) algorithm: CT and MRI.

Chernyak V, Santillan CS, Papadatos D, Sirlin CB
Abdom Radiol (NY) 2018 Jan;43(1):111-126. doi: 10.1007/s00261-017-1228-y. PMID: 28695233

See all (1383)

Diagnosis

Focal Benign Liver Lesions and Their Diagnostic Pitfalls.

Reizine E, Mulé S, Luciani A
Radiol Clin North Am 2022 Sep;60(5):755-773. Epub 2022 Jul 4 doi: 10.1016/j.rcl.2022.05.005. PMID: 35989043

Benign liver tumours: understanding molecular physiology to adapt clinical management.

Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851

A practical diagnostic approach to hepatic masses.

Vyas M, Jain D
Indian J Pathol Microbiol 2018 Jan-Mar;61(1):2-17. doi: 10.4103/IJPM.IJPM_578_17. PMID: 29567877

ACG clinical guideline: the diagnosis and management of focal liver lesions.

Marrero JA, Ahn J, Rajender Reddy K; Americal College of Gastroenterology
Am J Gastroenterol 2014 Sep;109(9):1328-47; quiz 1348. Epub 2014 Aug 19 doi: 10.1038/ajg.2014.213. PMID: 25135008

Benign liver tumors.

Nichols FC 3rd, van Heerden JA, Weiland LH
Surg Clin North Am 1989 Apr;69(2):297-314. doi: 10.1016/s0039-6109(16)44787-0. PMID: 2538935

See all (2189)

Therapy

In vivo detection of bile duct pre-cancer with endoscopic light scattering spectroscopy.

Pleskow DK, Sawhney MS, Upputuri PK, Berzin TM, Coughlan MF, Khan U, Glyavina M, Zhang X, Chen L, Sheil CJ, Cohen JM, Vitkin E, Zakharov YN, Itzkan I, Zhang L, Qiu L, Perelman LT
Nat Commun 2023 Jan 7;14(1):109. doi: 10.1038/s41467-022-35780-7. PMID: 36611024 Free PMC Article

Viral hepatitis in haemophilia: historical perspective and current management.

Isfordink CJ, van Erpecum KJ, van der Valk M, Mauser-Bunschoten EP, Makris M
Br J Haematol 2021 Oct;195(2):174-185. Epub 2021 May 6 doi: 10.1111/bjh.17438. PMID: 33955555

Surgery for cholangiocarcinoma.

Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM, Groot Koerkamp B
Liver Int 2019 May;39 Suppl 1(Suppl Suppl 1):143-155. doi: 10.1111/liv.14089. PMID: 30843343 Free PMC Article

Surgical management of adrenocortical carcinoma.

Ranvier GG, Inabnet WB 3rd
Endocrinol Metab Clin North Am 2015 Jun;44(2):435-52. Epub 2015 Mar 17 doi: 10.1016/j.ecl.2015.02.008. PMID: 26038210

Talaporfin sodium.

Wang S, Bromley E, Xu L, Chen JC, Keltner L
Expert Opin Pharmacother 2010 Jan;11(1):133-40. doi: 10.1517/14656560903463893. PMID: 20001435

See all (506)

Prognosis

Endoscopic Evaluation and Management of Cholangiocarcinoma.

Das R, Singhi AD, Slivka A
Gastroenterol Clin North Am 2022 Sep;51(3):519-535. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.003. PMID: 36153108

Benign liver tumours: understanding molecular physiology to adapt clinical management.

Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851

Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives.

Vallianou N, Christodoulatos GS, Karampela I, Tsilingiris D, Magkos F, Stratigou T, Kounatidis D, Dalamaga M
Biomolecules 2021 Dec 31;12(1) doi: 10.3390/biom12010056. PMID: 35053205 Free PMC Article

Imaging of Intrahepatic Cholangiocarcinoma.

Mar WA, Chan HK, Trivedi SB, Berggruen SM
Semin Ultrasound CT MR 2021 Aug;42(4):366-380. Epub 2021 Apr 20 doi: 10.1053/j.sult.2021.04.001. PMID: 34130849

Management of benign hepatic tumors.

Buell JF, Tranchart H, Cannon R, Dagher I
Surg Clin North Am 2010 Aug;90(4):719-35. Epub 2010 Jun 8 doi: 10.1016/j.suc.2010.04.006. PMID: 20637943

See all (1018)

Clinical prediction guides

Artificial intelligence in liver ultrasound.

Cao LL, Peng M, Xie X, Chen GQ, Huang SY, Wang JY, Jiang F, Cui XW, Dietrich CF
World J Gastroenterol 2022 Jul 21;28(27):3398-3409. doi: 10.3748/wjg.v28.i27.3398. PMID: 36158262 Free PMC Article

Benign liver tumours: understanding molecular physiology to adapt clinical management.

Nault JC, Paradis V, Ronot M, Zucman-Rossi J
Nat Rev Gastroenterol Hepatol 2022 Nov;19(11):703-716. Epub 2022 Jul 14 doi: 10.1038/s41575-022-00643-5. PMID: 35835851

Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives.

Vallianou N, Christodoulatos GS, Karampela I, Tsilingiris D, Magkos F, Stratigou T, Kounatidis D, Dalamaga M
Biomolecules 2021 Dec 31;12(1) doi: 10.3390/biom12010056. PMID: 35053205 Free PMC Article

LI-RADS categories: concepts, definitions, and criteria.

Santillan C, Chernyak V, Sirlin C
Abdom Radiol (NY) 2018 Jan;43(1):101-110. doi: 10.1007/s00261-017-1334-x. PMID: 29038857

LI-RADS(®) algorithm: CT and MRI.

Chernyak V, Santillan CS, Papadatos D, Sirlin CB
Abdom Radiol (NY) 2018 Jan;43(1):111-126. doi: 10.1007/s00261-017-1228-y. PMID: 28695233

See all (907)

Recent systematic reviews

Risk factors of postoperative bile leakage after liver resection: A systematic review and meta-analysis.

Xue S, Wang H, Chen X, Zeng Y
Cancer Med 2023 Jul;12(14):14922-14936. Epub 2023 Jun 16 doi: 10.1002/cam4.6128. PMID: 37326370 Free PMC Article

A systematic review and meta-analysis of spectral CT to differentiate focal liver lesions.

Bhandari A, Koppen J, Wastney T, Hacking C
Clin Radiol 2023 Jun;78(6):430-436. Epub 2023 Mar 11 doi: 10.1016/j.crad.2023.02.017. PMID: 37019736

Scoping review of clinical practice guidelines on the management of benign liver tumours.

Haring MPD, Cuperus FJC, Duiker EW, de Haas RJ, de Meijer VE
BMJ Open Gastroenterol 2021 Aug;8(1) doi: 10.1136/bmjgast-2020-000592. PMID: 34362758 Free PMC Article

Behavior and complications of hepatocellular adenoma during pregnancy and puerperium: a retrospective study and systematic review.

Haring MPD, Spijkerboer CS, Cuperus FJC, Duiker EW, de Jong KP, de Haas RJ, de Meijer VE
HPB (Oxford) 2021 Aug;23(8):1152-1163. Epub 2021 Apr 28 doi: 10.1016/j.hpb.2021.04.019. PMID: 33985906

Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.

Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503

See all (25)

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Benign Liver Epithelial Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity