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Squamous cell carcinoma of the vulva

MedGen UID:
79201
•Concept ID:
C0280856
•
Neoplastic Process
Synonyms: CA - Squamous cell carcinoma of vulva; Epidermoid Carcinoma of the Vulva; epidermoid carcinoma of the vulva; Epidermoid Carcinoma of Vulva; epidermoid carcinoma of vulva; Epidermoid Cell Carcinoma of the Vulva; epidermoid cell carcinoma of the vulva; Epidermoid Cell Carcinoma of Vulva; epidermoid cell carcinoma of vulva; Epithelioma of vulva; mammalian vulva squamous cell carcinoma; SCC - Squamous cell carcinoma of vulva; Squamous Cell Carcinoma of the Vulva; squamous cell carcinoma of the vulva; Squamous cell carcinoma of vulva; Squamous Cell Carcinoma of Vulva; squamous cell carcinoma of vulva; Vulva Epidermoid Carcinoma; vulva epidermoid carcinoma; Vulva Epidermoid Cell Carcinoma; vulva epidermoid cell carcinoma; Vulva Squamous Cell Carcinoma; vulva squamous cell carcinoma; Vulval squamous cell carcinoma; Vulvar Epidermoid Carcinoma; vulvar epidermoid carcinoma; Vulvar Epidermoid Cell Carcinoma; vulvar epidermoid cell carcinoma; vulvar squamous cell cancer; Vulvar Squamous Cell Carcinoma; vulvar squamous cell carcinoma; Vulvar squamous cell carcinoma
SNOMED CT: Epithelioma of vulva (254895003); SCC - Squamous cell carcinoma of vulva (254895003); CA - Squamous cell carcinoma of vulva (254895003); Squamous cell carcinoma of vulva (254895003)
 
HPO: HP:0030417
Monarch Initiative: MONDO:0024609
Orphanet: ORPHA494448

Definition

A cancer that originates in the squamous cells that line the surface of the vulva. [from HPO]

Professional guidelines

PubMed

Squamous cell carcinoma of the vulva: a review of present management and future considerations.
Buchanan T, Mutch D
Expert Rev Anticancer Ther 2019 Jan;19(1):43-50. Epub 2018 Oct 26 doi: 10.1080/14737140.2019.1538797. PMID: 30336700
Systemic treatment of vulvar cancer.
Mahner S, Prieske K, Grimm D, Trillsch F, Prieske S, von Amsberg G, Petersen C, Mueller V, Jaenicke F, Woelber L
Expert Rev Anticancer Ther 2015 Jun;15(6):629-37. Epub 2015 May 21 doi: 10.1586/14737140.2015.1037837. PMID: 25997120
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

Recent clinical studies

Etiology

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
A phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva: a gynecologic oncology group study.
Moore DH, Ali S, Koh WJ, Michael H, Barnes MN, McCourt CK, Homesley HD, Walker JL
Gynecol Oncol 2012 Mar;124(3):529-33. Epub 2011 Nov 9 doi: 10.1016/j.ygyno.2011.11.003. PMID: 22079361
Squamous cell carcinoma of the vulva: a review of 424 patients, 1956-1974.
Iversen T, Aalders JG, Christensen A, Kolstad P
Gynecol Oncol 1980 Jun;9(3):271-9. doi: 10.1016/0090-8258(80)90038-4. PMID: 7380345

Diagnosis

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Squamous cell carcinoma of the vulva diagnosed by a dermatologist.
Michels IB, Tonello CS, Soares CT
An Bras Dermatol 2019 Nov-Dec;94(6):771-772. Epub 2019 Nov 6 doi: 10.1016/j.abd.2019.04.005. PMID: 31789242Free PMC Article
Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Vulvar carcinoma.
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Therapy

Immune checkpoints inhibitors in metastatic squamous cell carcinoma of the vulva.
Assi T, Kattan J, Othman A, Farhat F
Future Oncol 2021 Aug;17(24):3133-3135. Epub 2021 Jul 2 doi: 10.2217/fon-2021-0610. PMID: 34213372
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
A phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva: a gynecologic oncology group study.
Moore DH, Ali S, Koh WJ, Michael H, Barnes MN, McCourt CK, Homesley HD, Walker JL
Gynecol Oncol 2012 Mar;124(3):529-33. Epub 2011 Nov 9 doi: 10.1016/j.ygyno.2011.11.003. PMID: 22079361
A patient with lichen sclerosus, Langerhans cell histiocytosis, and invasive squamous cell carcinoma of the vulva.
Simons M, Van De Nieuwenhof HP, Van Der Avoort IA, Bulten J, De Hullu JA
Am J Obstet Gynecol 2010 Aug;203(2):e7-10. Epub 2010 Jun 11 doi: 10.1016/j.ajog.2010.04.023. PMID: 20541173
Chemotherapy of squamous cell carcinoma of the vulva: a review.
Deppe G, Cohen CJ, Bruckner HW
Gynecol Oncol 1979 Jun;7(3):345-8. doi: 10.1016/0090-8258(79)90112-4. PMID: 87359

Prognosis

Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva.
Gadducci A, Tana R, Barsotti C, Guerrieri ME, Genazzani AR
Crit Rev Oncol Hematol 2012 Jul;83(1):71-83. Epub 2011 Oct 19 doi: 10.1016/j.critrevonc.2011.09.003. PMID: 22015047
A patient with lichen sclerosus, Langerhans cell histiocytosis, and invasive squamous cell carcinoma of the vulva.
Simons M, Van De Nieuwenhof HP, Van Der Avoort IA, Bulten J, De Hullu JA
Am J Obstet Gynecol 2010 Aug;203(2):e7-10. Epub 2010 Jun 11 doi: 10.1016/j.ajog.2010.04.023. PMID: 20541173
Vulvar carcinoma.
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775
Squamous cell carcinoma of the vulva: a review of 424 patients, 1956-1974.
Iversen T, Aalders JG, Christensen A, Kolstad P
Gynecol Oncol 1980 Jun;9(3):271-9. doi: 10.1016/0090-8258(80)90038-4. PMID: 7380345

Clinical prediction guides

Tumor budding activity is an independent prognostic factor in squamous cell carcinoma of the vulva.
Zare SY, Ciscato A, Fadare O
Hum Pathol 2022 Aug;126:77-86. Epub 2022 May 18 doi: 10.1016/j.humpath.2022.05.009. PMID: 35594936
Nicotinamide N-methyltransferase expression in squamous cell carcinoma of the vulva.
Çelik ZE, Akar S, Fındık S, Aytekin E, Çelik Ç
J Obstet Gynaecol 2022 Aug;42(6):2325-2330. Epub 2022 May 2 doi: 10.1080/01443615.2022.2049722. PMID: 35499473
Prevalence and type distribution of human papillomavirus in squamous cell carcinoma and intraepithelial neoplasia of the vulva.
Faber MT, Sand FL, Albieri V, Norrild B, Kjaer SK, Verdoodt F
Int J Cancer 2017 Sep 15;141(6):1161-1169. Epub 2017 Jun 21 doi: 10.1002/ijc.30821. PMID: 28577297
Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva.
Gadducci A, Tana R, Barsotti C, Guerrieri ME, Genazzani AR
Crit Rev Oncol Hematol 2012 Jul;83(1):71-83. Epub 2011 Oct 19 doi: 10.1016/j.critrevonc.2011.09.003. PMID: 22015047
Surgical interventions for early squamous cell carcinoma of the vulva.
Ansink A, van der Velden J
Cochrane Database Syst Rev 2000;2000(2):CD002036. doi: 10.1002/14651858.CD002036. PMID: 10796849Free PMC Article

Recent systematic reviews

Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review.
Te Grootenhuis NC, Pouwer AW, de Bock GH, Hollema H, Bulten J, van der Zee AGJ, de Hullu JA, Oonk MHM
Gynecol Oncol 2018 Mar;148(3):622-631. Epub 2017 Nov 12 doi: 10.1016/j.ygyno.2017.11.006. PMID: 29137809
Prevalence and type distribution of human papillomavirus in squamous cell carcinoma and intraepithelial neoplasia of the vulva.
Faber MT, Sand FL, Albieri V, Norrild B, Kjaer SK, Verdoodt F
Int J Cancer 2017 Sep 15;141(6):1161-1169. Epub 2017 Jun 21 doi: 10.1002/ijc.30821. PMID: 28577297
Prognostic implications of extranodal extension in node-positive squamous cell carcinoma of the vulva: A systematic review and meta-analysis.
Luchini C, Nottegar A, Solmi M, Sergi G, Manzato E, Capelli P, Scarpa A, Veronese N
Surg Oncol 2016 Mar;25(1):60-5. Epub 2015 Sep 14 doi: 10.1016/j.suronc.2015.09.005. PMID: 26394825
Lymphatic mapping and sentinel node biopsy in squamous cell carcinoma of the vulva: systematic review and meta-analysis of the literature.
Hassanzade M, Attaran M, Treglia G, Yousefi Z, Sadeghi R
Gynecol Oncol 2013 Jul;130(1):237-45. Epub 2013 Apr 20 doi: 10.1016/j.ygyno.2013.04.023. PMID: 23612317
Surgical interventions for early squamous cell carcinoma of the vulva.
Ansink A, van der Velden J
Cochrane Database Syst Rev 2000;2000(2):CD002036. doi: 10.1002/14651858.CD002036. PMID: 10796849Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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