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Skin Appendage Adenoma

MedGen UID:
90766
•Concept ID:
C0334342
•
Neoplastic Process
Synonyms: Adenoma of Adnexa; Adenoma of Skin Appendage; Adnexal Adenoma; Adnexal tumor; Skin appendage adenoma
SNOMED CT: Skin appendage adenoma (55681005); Adnexal tumor (55681005)

Definition

A benign epithelial neoplasm arising from the sebaceous or sweat glands. Representative examples include sebaceous adenoma, tubular apocrine adenoma, and hidradenoma. [from NCI]

Professional guidelines

PubMed

Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.
Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696
A new treatment for syringoma. Combination of carbon dioxide laser and trichloroacetic acid.
Kang WH, Kim NS, Kim YB, Shim WC
Dermatol Surg 1998 Dec;24(12):1370-4. PMID: 9865206
Antibodies to intermediate filament proteins. The differential diagnosis of cutaneous tumors.
Miettinen M, Lehto VP, Virtanen I
Arch Dermatol 1985 Jun;121(6):736-41. PMID: 2408582

Recent clinical studies

Etiology

Multimodality Imaging of Benign and Malignant Diseases of the Nipple-Areolar Complex.
Guirguis MS, Arribas EM, Kapoor MM, Patel MM, Perez F, Nia ES, Ding Q, Moseley TW, Adrada BE
Radiographics 2024 Apr;44(4):e230113. doi: 10.1148/rg.230113. PMID: 38483829
Genetics of adnexal tumors: An update.
Kervarrec T, Sohier P, Pissaloux D, de la Fouchardiere A, Cribier B, Battistella M, Macagno N
Ann Dermatol Venereol 2023 Sep;150(3):202-207. Epub 2023 Jun 1 doi: 10.1016/j.annder.2023.03.003. PMID: 37270318
Sub-macroscopic skin presentation of acromegaly and effect of pituitary tumor surgery: A study using dermatoscopy and ultra-high-frequency ultrasound.
Guo X, Wang Y, Yao Y, Bao X, Duan L, Zhu H, Xing B, Liu J
Front Endocrinol (Lausanne) 2022;13:1093942. Epub 2023 Jan 10 doi: 10.3389/fendo.2022.1093942. PMID: 36818464Free PMC Article
Plaque-Type Syringoma Masquerading as Microcystic Adnexal Carcinoma: Review of the Literature and Description of a Novel Technique That Emphasizes Lesion Architecture to Help Make the Diagnosis.
Clark M, Duprey C, Sutton A, Pelster MW, Maher IA, Hurley MY, Vidal C
Am J Dermatopathol 2019 Sep;41(9):e98-e101. doi: 10.1097/DAD.0000000000001415. PMID: 30921007
Tumors of the skin composed of large cells with abundant eosinophilic cytoplasm.
Suster S
Semin Diagn Pathol 1999 May;16(2):162-77. PMID: 10452581

Diagnosis

Genetics of adnexal tumors: An update.
Kervarrec T, Sohier P, Pissaloux D, de la Fouchardiere A, Cribier B, Battistella M, Macagno N
Ann Dermatol Venereol 2023 Sep;150(3):202-207. Epub 2023 Jun 1 doi: 10.1016/j.annder.2023.03.003. PMID: 37270318
Hidradenocarcinoma.
de Lima AA, Santos M, de Morais PM, Rodrigues CAC
An Bras Dermatol 2021 Mar-Apr;96(2):251-253. Epub 2021 Feb 5 doi: 10.1016/j.abd.2020.03.023. PMID: 33597101Free PMC Article
Periungual eccrine poroma.
Fierro-Arias L, Calderón L, Peniche-Castellanos A, Mercadillo-Pérez P
J Cutan Med Surg 2015 Jan-Feb;19(1):84-6. Epub 2015 Jan 1 doi: 10.2310/7750.2014.14012. PMID: 25775671
Adnexal tumours of the skin as markers of cancer-prone syndromes.
Kanitakis J
J Eur Acad Dermatol Venereol 2010 Apr;24(4):379-87. Epub 2009 Sep 10 doi: 10.1111/j.1468-3083.2009.03420.x. PMID: 19744258
Tumors of the skin composed of large cells with abundant eosinophilic cytoplasm.
Suster S
Semin Diagn Pathol 1999 May;16(2):162-77. PMID: 10452581

Therapy

Multi-organ carcinogenicity by inhalation exposure to 2-Bromopropane in rats.
Senoh H, Kasai T, Hirai S, Furukawa Y, Misumi K, Goto Y, Takanobu K, Matsumoto M, Fukushima S, Aiso S
J Occup Health 2023 Jan;65(1):e12388. doi: 10.1002/1348-9585.12388. PMID: 36756793Free PMC Article
Sub-macroscopic skin presentation of acromegaly and effect of pituitary tumor surgery: A study using dermatoscopy and ultra-high-frequency ultrasound.
Guo X, Wang Y, Yao Y, Bao X, Duan L, Zhu H, Xing B, Liu J
Front Endocrinol (Lausanne) 2022;13:1093942. Epub 2023 Jan 10 doi: 10.3389/fendo.2022.1093942. PMID: 36818464Free PMC Article
Eruptions of Sebaceous Adenomas and Carcinomas Induced by Tacrolimus.
Navarro-Navarro I, Jiménez-Gallo D, Tello-Collantes K, Linares-Barrios M
Actas Dermosifiliogr (Engl Ed) 2021 Apr;112(4):379-381. Epub 2020 Oct 28 doi: 10.1016/j.ad.2019.11.008. PMID: 33129778
Plaque-Type Syringoma Masquerading as Microcystic Adnexal Carcinoma: Review of the Literature and Description of a Novel Technique That Emphasizes Lesion Architecture to Help Make the Diagnosis.
Clark M, Duprey C, Sutton A, Pelster MW, Maher IA, Hurley MY, Vidal C
Am J Dermatopathol 2019 Sep;41(9):e98-e101. doi: 10.1097/DAD.0000000000001415. PMID: 30921007
Isobaric laparoendoscopic single-site surgery with wound retractor for adnexal tumors: a single center experience with the initial 100 cases.
Takeda A, Imoto S, Mori M, Nakano T, Nakamura H
Eur J Obstet Gynecol Reprod Biol 2011 Aug;157(2):190-6. Epub 2011 Apr 5 doi: 10.1016/j.ejogrb.2011.02.018. PMID: 21470765

Prognosis

Incidence, survival, and prognostic factors associated with malignant nodular hidradenoma in the United States.
Ugwu N, Cheraghlou S, Ko CJ, Cohen JM
J Am Acad Dermatol 2023 Apr;88(4):875-877. Epub 2022 Oct 11 doi: 10.1016/j.jaad.2022.09.053. PMID: 36228937
Female Adnexal Tumor of Probable Wolffian Origin.
Hou Y, Yang B, Zhang G
Arch Pathol Lab Med 2022 Jan 2;146(2):166-171. doi: 10.5858/arpa.2020-0432-OA. PMID: 34133728
Plaque-Type Syringoma Masquerading as Microcystic Adnexal Carcinoma: Review of the Literature and Description of a Novel Technique That Emphasizes Lesion Architecture to Help Make the Diagnosis.
Clark M, Duprey C, Sutton A, Pelster MW, Maher IA, Hurley MY, Vidal C
Am J Dermatopathol 2019 Sep;41(9):e98-e101. doi: 10.1097/DAD.0000000000001415. PMID: 30921007
Hidradenocarcinomas: a brief review and future directions.
Gauerke S, Driscoll JJ
Arch Pathol Lab Med 2010 May;134(5):781-5. doi: 10.5858/134.5.781. PMID: 20441512
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma.
Uede K, Yamamoto Y, Furukawa F
J Dermatol 2004 Jan;31(1):32-8. doi: 10.1111/j.1346-8138.2004.tb00501.x. PMID: 14739501

Clinical prediction guides

Nectin-4 expression in a subset of cutaneous adnexal carcinomas: A potential target for therapy with enfortumab vedotin.
Cho WC, Saade R, Nagarajan P, Aung PP, Milton DR, Marques-Piubelli ML, Hudgens C, Ledesma D, Nelson K, Ivan D, Zhang M, Torres-Cabala CA, Campbell M, Alhalabi O, Prieto VG, Wistuba II, Esmaeli B, Curry JL
J Cutan Pathol 2024 May;51(5):360-367. Epub 2024 Jan 10 doi: 10.1111/cup.14579. PMID: 38200650
The role of reflectance confocal microscopy in the diagnosis of eccrine poroma: A retrospective case-control study.
Di Tullio F, Mandel VD, Ignazio S, Cinotti E, Kaleci S, Ciardo S, Peccerillo F, Longo C, Farnetani F, Pellacani G
Exp Dermatol 2022 Nov;31(11):1779-1790. Epub 2022 Aug 19 doi: 10.1111/exd.14658. PMID: 36053956
Magnetic Resonance Imaging Characteristics of Poroma and Porocarcinoma.
Kawaguchi M, Kato H, Imada H, Miyazaki T, Matsuyama K, Seishima M, Matsuo M
J Comput Assist Tomogr 2021 May-Jun 01;45(3):447-451. doi: 10.1097/RCT.0000000000001146. PMID: 33797441
Expression of epidermal stem cell markers in skin and adnexal malignancies.
Quist SR, Eckardt M, Kriesche A, Gollnick HP
Br J Dermatol 2016 Sep;175(3):520-30. Epub 2016 Jul 27 doi: 10.1111/bjd.14494. PMID: 26914519
Plaque-type syringoma: two cases misdiagnosed as microcystic adnexal carcinoma.
Suwattee P, McClelland MC, Huiras EE, Warshaw EM, Lee PK, Kaye VN, McCalmont TH, Niehans GA
J Cutan Pathol 2008 Jun;35(6):570-4. Epub 2007 Nov 12 doi: 10.1111/j.1600-0560.2007.00843.x. PMID: 18005172

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