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Diffuse Glioma

MedGen UID:
927222
Concept ID:
C4289690
Neoplastic Process

Definition

A glioma that has diffusely infiltrated the surrounding central nervous system tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Glioma

Professional guidelines

PubMed

van den Bent M, Saratsis AM, Geurts M, Franceschi E
Neuro Oncol 2024 May 3;26(Supplement_2):S110-S124. doi: 10.1093/neuonc/noad220. PMID: 38102230Free PMC Article
van den Bent MJ, Geurts M, French PJ, Smits M, Capper D, Bromberg JEC, Chang SM
Lancet 2023 Oct 28;402(10412):1564-1579. Epub 2023 Sep 19 doi: 10.1016/S0140-6736(23)01054-1. PMID: 37738997
Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, Jiang C, Yang X, Kang C, Qiu X, Li W, Li S, Chen L, Li X, Liu Z, Wang W, Bai H, Yao Y, Li S, Wu A, Sai K, Li G, Yao K, Wei X, Liu X, Zhang Z, Dai Y, Lv S, Wang L, Lin Z, Dong J, Xu G, Ma X, Zhang W, Zhang C, Chen B, You G, Wang Y, Wang Y, Bao Z, Yang P, Fan X, Liu X, Zhao Z, Wang Z, Li Y, Wang Z, Li G, Fang S, Li L, Liu Y, Liu S, Shan X, Liu Y, Chai R, Hu H, Chen J, Yan W, Cai J, Wang H, Chen L, Yang Y, Wang Y, Han L, Wang Q; Chinese Glioma Cooperative Group (CGCG); Society for Neuro‐Oncology of China (SNO-China); Chinese Brain Cancer Association (CBCA); Chinese Glioma Genome Atlas (CGGA); Asian Glioma Genome Atlas (AGGA) network
Cancer Lett 2021 Feb 28;499:60-72. Epub 2020 Nov 6 doi: 10.1016/j.canlet.2020.10.050. PMID: 33166616

Recent clinical studies

Etiology

Mu Q, Chai R, Pang B, Yang Y, Liu H, Zhao Z, Bao Z, Song D, Zhu Z, Yan M, Jiang B, Mo Z, Tang J, Sa JK, Cho HJ, Chang Y, Chan KHY, Loi DSC, Tam SST, Chan AKY, Wu AR, Liu Z, Poon WS, Ng HK, Chan DTM, Iavarone A, Nam DH, Jiang T, Wang J
Sci Transl Med 2023 Oct 4;15(716):eadh4181. doi: 10.1126/scitranslmed.adh4181. PMID: 37792958
Nicholson JG, Fine HA
Cancer Discov 2021 Mar;11(3):575-590. Epub 2021 Feb 8 doi: 10.1158/2159-8290.CD-20-1474. PMID: 33558264
Molinaro AM, Taylor JW, Wiencke JK, Wrensch MR
Nat Rev Neurol 2019 Jul;15(7):405-417. Epub 2019 Jun 21 doi: 10.1038/s41582-019-0220-2. PMID: 31227792Free PMC Article
Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH; TCGA Research Network, Noushmehr H, Iavarone A, Verhaak RG
Cell 2016 Jan 28;164(3):550-63. doi: 10.1016/j.cell.2015.12.028. PMID: 26824661Free PMC Article
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797

Diagnosis

van den Bent M, Saratsis AM, Geurts M, Franceschi E
Neuro Oncol 2024 May 3;26(Supplement_2):S110-S124. doi: 10.1093/neuonc/noad220. PMID: 38102230Free PMC Article
Mu Q, Chai R, Pang B, Yang Y, Liu H, Zhao Z, Bao Z, Song D, Zhu Z, Yan M, Jiang B, Mo Z, Tang J, Sa JK, Cho HJ, Chang Y, Chan KHY, Loi DSC, Tam SST, Chan AKY, Wu AR, Liu Z, Poon WS, Ng HK, Chan DTM, Iavarone A, Nam DH, Jiang T, Wang J
Sci Transl Med 2023 Oct 4;15(716):eadh4181. doi: 10.1126/scitranslmed.adh4181. PMID: 37792958
van den Bent MJ, Geurts M, French PJ, Smits M, Capper D, Bromberg JEC, Chang SM
Lancet 2023 Oct 28;402(10412):1564-1579. Epub 2023 Sep 19 doi: 10.1016/S0140-6736(23)01054-1. PMID: 37738997
Nicholson JG, Fine HA
Cancer Discov 2021 Mar;11(3):575-590. Epub 2021 Feb 8 doi: 10.1158/2159-8290.CD-20-1474. PMID: 33558264
Molinaro AM, Taylor JW, Wiencke JK, Wrensch MR
Nat Rev Neurol 2019 Jul;15(7):405-417. Epub 2019 Jun 21 doi: 10.1038/s41582-019-0220-2. PMID: 31227792Free PMC Article

Therapy

Lamb YN
Drugs 2024 Oct;84(10):1325-1331. Epub 2024 Oct 8 doi: 10.1007/s40265-024-02097-2. PMID: 39375303Free PMC Article
Mu Q, Chai R, Pang B, Yang Y, Liu H, Zhao Z, Bao Z, Song D, Zhu Z, Yan M, Jiang B, Mo Z, Tang J, Sa JK, Cho HJ, Chang Y, Chan KHY, Loi DSC, Tam SST, Chan AKY, Wu AR, Liu Z, Poon WS, Ng HK, Chan DTM, Iavarone A, Nam DH, Jiang T, Wang J
Sci Transl Med 2023 Oct 4;15(716):eadh4181. doi: 10.1126/scitranslmed.adh4181. PMID: 37792958
Hollon T, Jiang C, Chowdury A, Nasir-Moin M, Kondepudi A, Aabedi A, Adapa A, Al-Holou W, Heth J, Sagher O, Lowenstein P, Castro M, Wadiura LI, Widhalm G, Neuschmelting V, Reinecke D, von Spreckelsen N, Berger MS, Hervey-Jumper SL, Golfinos JG, Snuderl M, Camelo-Piragua S, Freudiger C, Lee H, Orringer DA
Nat Med 2023 Apr;29(4):828-832. Epub 2023 Mar 23 doi: 10.1038/s41591-023-02252-4. PMID: 36959422Free PMC Article
Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, Jiang C, Yang X, Kang C, Qiu X, Li W, Li S, Chen L, Li X, Liu Z, Wang W, Bai H, Yao Y, Li S, Wu A, Sai K, Li G, Yao K, Wei X, Liu X, Zhang Z, Dai Y, Lv S, Wang L, Lin Z, Dong J, Xu G, Ma X, Zhang W, Zhang C, Chen B, You G, Wang Y, Wang Y, Bao Z, Yang P, Fan X, Liu X, Zhao Z, Wang Z, Li Y, Wang Z, Li G, Fang S, Li L, Liu Y, Liu S, Shan X, Liu Y, Chai R, Hu H, Chen J, Yan W, Cai J, Wang H, Chen L, Yang Y, Wang Y, Han L, Wang Q; Chinese Glioma Cooperative Group (CGCG); Society for Neuro‐Oncology of China (SNO-China); Chinese Brain Cancer Association (CBCA); Chinese Glioma Genome Atlas (CGGA); Asian Glioma Genome Atlas (AGGA) network
Cancer Lett 2021 Feb 28;499:60-72. Epub 2020 Nov 6 doi: 10.1016/j.canlet.2020.10.050. PMID: 33166616
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797

Prognosis

van den Bent M, Saratsis AM, Geurts M, Franceschi E
Neuro Oncol 2024 May 3;26(Supplement_2):S110-S124. doi: 10.1093/neuonc/noad220. PMID: 38102230Free PMC Article
Mu Q, Chai R, Pang B, Yang Y, Liu H, Zhao Z, Bao Z, Song D, Zhu Z, Yan M, Jiang B, Mo Z, Tang J, Sa JK, Cho HJ, Chang Y, Chan KHY, Loi DSC, Tam SST, Chan AKY, Wu AR, Liu Z, Poon WS, Ng HK, Chan DTM, Iavarone A, Nam DH, Jiang T, Wang J
Sci Transl Med 2023 Oct 4;15(716):eadh4181. doi: 10.1126/scitranslmed.adh4181. PMID: 37792958
Nicholson JG, Fine HA
Cancer Discov 2021 Mar;11(3):575-590. Epub 2021 Feb 8 doi: 10.1158/2159-8290.CD-20-1474. PMID: 33558264
Molinaro AM, Taylor JW, Wiencke JK, Wrensch MR
Nat Rev Neurol 2019 Jul;15(7):405-417. Epub 2019 Jun 21 doi: 10.1038/s41582-019-0220-2. PMID: 31227792Free PMC Article
van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE
Drug Resist Updat 2015 Mar;19:1-12. Epub 2015 Mar 6 doi: 10.1016/j.drup.2015.02.002. PMID: 25791797

Clinical prediction guides

Kang KM, Song J, Choi Y, Park C, Park JE, Kim HS, Park SH, Park CK, Choi SH
Radiology 2024 May;311(2):e233120. doi: 10.1148/radiol.233120. PMID: 38713025
Mu Q, Chai R, Pang B, Yang Y, Liu H, Zhao Z, Bao Z, Song D, Zhu Z, Yan M, Jiang B, Mo Z, Tang J, Sa JK, Cho HJ, Chang Y, Chan KHY, Loi DSC, Tam SST, Chan AKY, Wu AR, Liu Z, Poon WS, Ng HK, Chan DTM, Iavarone A, Nam DH, Jiang T, Wang J
Sci Transl Med 2023 Oct 4;15(716):eadh4181. doi: 10.1126/scitranslmed.adh4181. PMID: 37792958
Hollon T, Jiang C, Chowdury A, Nasir-Moin M, Kondepudi A, Aabedi A, Adapa A, Al-Holou W, Heth J, Sagher O, Lowenstein P, Castro M, Wadiura LI, Widhalm G, Neuschmelting V, Reinecke D, von Spreckelsen N, Berger MS, Hervey-Jumper SL, Golfinos JG, Snuderl M, Camelo-Piragua S, Freudiger C, Lee H, Orringer DA
Nat Med 2023 Apr;29(4):828-832. Epub 2023 Mar 23 doi: 10.1038/s41591-023-02252-4. PMID: 36959422Free PMC Article
Platten M, Bunse L, Wick A, Bunse T, Le Cornet L, Harting I, Sahm F, Sanghvi K, Tan CL, Poschke I, Green E, Justesen S, Behrens GA, Breckwoldt MO, Freitag A, Rother LM, Schmitt A, Schnell O, Hense J, Misch M, Krex D, Stevanovic S, Tabatabai G, Steinbach JP, Bendszus M, von Deimling A, Schmitt M, Wick W
Nature 2021 Apr;592(7854):463-468. Epub 2021 Mar 24 doi: 10.1038/s41586-021-03363-z. PMID: 33762734Free PMC Article
Belgers V, Numan T, Kulik SD, Hillebrand A, de Witt Hamer PC, Geurts JJG, Reijneveld JC, Wesseling P, Klein M, Derks J, Douw L
J Neurooncol 2020 Mar;147(1):49-58. Epub 2020 Jan 17 doi: 10.1007/s11060-019-03386-7. PMID: 31953611Free PMC Article

Recent systematic reviews

Goliot N, Mohssine S, Stefan D, Leclerc A, Emery E, Riverain J, Missohou F, Geffrelot J, Kao W, Valable S, Balosso J, Lesueur P
Crit Rev Oncol Hematol 2024 Dec;204:104501. Epub 2024 Sep 7 doi: 10.1016/j.critrevonc.2024.104501. PMID: 39251047
Muzyka L, Goff NK, Choudhary N, Koltz MT
Int J Mol Sci 2023 Jun 21;24(13) doi: 10.3390/ijms241310456. PMID: 37445633Free PMC Article
Fauvet C, Villain M, Gatignol P
Neurosurg Rev 2023 Jun 29;46(1):156. doi: 10.1007/s10143-023-02073-6. PMID: 37382692
Lasocki A, Anjari M, Ӧrs Kokurcan S, Thust SC
Neuroradiology 2021 Mar;63(3):353-362. Epub 2020 Aug 25 doi: 10.1007/s00234-020-02532-7. PMID: 32840682
Fan X, Li Y, Shan X, You G, Wu Z, Li Z, Qiao H, Jiang T
Seizure 2018 Jul;59:16-23. Epub 2018 Apr 25 doi: 10.1016/j.seizure.2018.04.018. PMID: 29727741

Supplemental Content

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