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DCAF12 DDB1 and CUL4 associated factor 12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41460, updated on 9-Dec-2024

Summary

Official Symbol
DCAF12provided by FlyBase
Official Full Name
DDB1 and CUL4 associated factor 12provided by FlyBase
Primary source
FLYBASE:FBgn0037980
Locus tag
Dmel_CG3313
See related
AllianceGenome:FB:FBgn0037980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3313; dcaf12; Dmel\CG3313
Summary
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including autophagic cell death; evoked neurotransmitter secretion; and positive regulation of hippo signaling. Part of Cul4-RING E3 ubiquitin ligase complex. Is active in cytoplasm; nucleus; and presynapse. Is expressed in organism. Orthologous to human DCAF12 (DDB1 and CUL4 associated factor 12); DCAF12L1 (DDB1 and CUL4 associated factor 12 like 1); and DCAF12L2 (DDB1 and CUL4 associated factor 12 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See DCAF12 in Genome Data Viewer
Location:
87A5-87A5; 3-51 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12014943..12017031, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7840665..7842753, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tachykinin Neighboring gene Ectoderm-expressed 3 Neighboring gene Kelch like family member 18 Neighboring gene GRIP and coiled-coil domain containing 185 kDa Neighboring gene Spt3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex  
part_of Cul4-RING E3 ubiquitin ligase complex PubMed 
is_active_in cytoplasm PubMed 
is_active_in nucleus PubMed 
is_active_in presynapse PubMed 

General protein information

Preferred Names
DDB1 and CUL4 associated factor 12
Names
CG3313-PA
CG3313-PB
DCAF12 ortholog
DCAF12-PA
DCAF12-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12014943..12017031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275566.1NP_001262495.1  DDB1 and CUL4 associated factor 12, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262495.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T084, Q9VGE3
    Conserved Domains (2) summary
    COG2319
    Location:121400
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:173210
    7WD40; WD40 repeat [structural motif]
  2. NM_141888.5NP_650145.1  DDB1 and CUL4 associated factor 12, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650145.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T084, Q9VGE3
    Related
    FBpp0082028
    Conserved Domains (2) summary
    COG2319
    Location:121400
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:173210
    7WD40; WD40 repeat [structural motif]
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