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GPI1 phosphatidylinositol N-acetylglucosaminyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853130, updated on 9-Dec-2024

Summary

Official Symbol
GPI1
Official Full Name
phosphatidylinositol N-acetylglucosaminyltransferase
Primary source
SGD:S000003448
Locus tag
YGR216C
See related
AllianceGenome:SGD:S000003448; FungiDB:YGR216C; VEuPathDB:YGR216C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable glycosyltransferase activity. Predicted to contribute to phosphatidylinositol N-acetylglucosaminyltransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum. Part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 4. Orthologous to human PIGQ (phosphatidylinositol glycan anchor biosynthesis class Q). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See GPI1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (922633..924462, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S0A Neighboring gene mitochondrial 37S ribosomal protein RSM27 Neighboring gene Cch1p Neighboring gene tRNA-Gly

Interactions

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
located_in endoplasmic reticulum PubMed 
is_active_in endoplasmic reticulum  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex PubMed 
located_in membrane  

General protein information

Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase
NP_011732.1
  • Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1 are functional homologs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    922633..924462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181345.1NP_011732.1  TPA: phosphatidylinositol N-acetylglucosaminyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011732.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUZ9, P53306
    UniProtKB/TrEMBL
    A6ZUM7, B3LI20, C7GTX8, C8Z9A8, G2WEU5, N1P9Y5
    Conserved Domains (1) summary
    pfam05024
    Location:279469
    Gpi1; N-acetylglucosaminyl transferase component (Gpi1)
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