GEO DataSets

(Submitter supplied) The aim of the study was to determine the epitope targeted by 5H2 human Fab directed against NHBA and the crossreactivity aginst a panel of nine different NHBA long and short peptide variants (p2, p3, p5, p10, p17, p20, p21, p24, p29). 5H2 were diluted at 1:2000 and incubated on a non-commercial Protein Microarray platform printed with NHBAp2 specific recombinant protein fragments and full length NHBA of different variants.

Organism:

Neisseria meningitidis; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL24853

1 Sample

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Neisseria meningitidis serogroup B; Neisseria meningitidis; Homo sapiens

Type:

Protein profiling by protein array

4 related Platforms

57 Samples

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(Submitter supplied) The aim of the study was to determine the epitope targeted by four different HumAbs and the cross-reactivity to linear peptide epitopes of 10 different Neisserial Heparin Binding Antigen (NHBA) variants. the HumAbs were diluted at 1:60 and incubated on a custom PepStar Peptide Microarray platform printed with 561 different peptides.

Organism:

Neisseria meningitidis serogroup B; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL21866

4 Samples

Download data: TXT

(Submitter supplied) The aim of the study was to determine the epitope targeted by four different HumAbs and the cross-reactivity to linear peptide epitopes of 5 different Neisserial adesin A (NadA) variants. the HumAbs were diluted at 1:200 and incubated on a custom PepStar Peptide Microarray platform printed with 348 different peptides.

Organism:

Homo sapiens; Neisseria meningitidis serogroup B

Type:

Protein profiling by protein array

Platform:

GPL23476

11 Samples

Download data: TXT

(Submitter supplied) The aim of the study was to determine the epitope targeted by 5 different HumAbs and the cross-reactivity to linear peptide epitopes of 12 different factor H binding protein (fHbp) variants. The HumAbs were diluted at 1:200 and incubated on a custom PepStar Peptide Microarray platform printed with 363 different peptides.

Organism:

Homo sapiens; Neisseria meningitidis serogroup B

Type:

Protein profiling by protein array

Platform:

GPL23475

5 Samples

Download data: TXT

(Submitter supplied) The aim of the study was to determine the epitope targeted by a panel of Human Fabs. Fabs were diluted at 1:50 and incubated on a non-commercial Protein Microarray platform printed with fHbp, NHBA and NadA specific recombinant protein fragments and full length fHbp, NHBA and NadA of different variants.

Organism:

Neisseria meningitidis; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL23474

37 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Neisseria meningitidis; Neisseria meningitidis serogroup B; Mus musculus

Type:

Protein profiling by protein array

Platforms:

GPL21867 GPL21866

6 Samples

Download data: TXT

(Submitter supplied) The aim of the study was to determine the epitope targeted by 31E10/E7 mouse monoclonal antibody (mAb). mAb 31E10/E7 was diluted at 1:2000 and incubated on a non-commercial Protein Microarray platform printed with NHBA specific recombinant protein fragments and full length NHBA of different variants.

Organism:

Mus musculus; Neisseria meningitidis

Type:

Protein profiling by protein array

Platform:

GPL21867

3 Samples

Download data: TXT

(Submitter supplied) The aim of the study was to determine the epitope targeted by 31E10/E7 mouse monoclonal antibody (mAb) and the cross-reactivity to linear peptide epitopes of 10 different Neisserial Heparin Binding Antigen (NHBA) variants. mAb 31E10/E7 was diluted at 1:200 and incubated on a custom PepStar Peptide Microarray platform printed with 560 different peptides in three independent experiments.

Organism:

Neisseria meningitidis serogroup B; Mus musculus

Type:

Protein profiling by protein array

Platform:

GPL21866

3 Samples

Download data: TXT

(Submitter supplied) Epitope mapping studies aim to identify the binding sites of antibody-antigen interactions to enhance the development of vaccines, diagnostics and immunotherapeutic compounds. However, mapping is a laborious process employing time- and resource-consuming ‘wet bench’ techniques or epitope prediction software that are still in their infancy. For polymorphic antigens, another challenge is characterizing cross-reactivity between epitopes, teasing out distinctions between broadly cross-reactive responses, limited cross-reactions among variants and the truly type-specific responses. more...

Organism:

Borreliella burgdorferi; Peromyscus leucopus; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL17008

110 Samples

Download data: TXT