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Links from GEO DataSets

Items: 20

1.

Whole transcriptome profiling of Japanese nonalcoholic fatty liver disease cohort.

(Submitter supplied) Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) that is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis, which lead to progressed cirrhosis and hepatocellular carcinoma. Despite its increasing prevalence on a global scale, the pathogenesis of NASH progression is not well understood. To elucidate the underlying mechanisms of NASH progression, we conducted transcriptome analyses of Japanese NAFLD cohort in our facility.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
94 Samples
Download data: TXT
2.

Liver tumor gene expression profile of liver-specific PTEN KO, PTEN/SCAP double KO mice

(Submitter supplied) Nonalcoholic steatohepatitis (NASH), a severe form of nonalcoholic fatty liver disease, is characterized by hepatic steatosis and hepatocellular injury and progresss cirrhosis and hepatocellular carcinoma. Sterol regulatory elment-binding proteins (SREBPs) are master regulators of lipogenesis. Liver-specific PTEN knockout (KO) mice show constitutive upregulation of SREBP through PI3K-Akt pathway activation, leading to spontaneous fatty liver and subsequent HCC development. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
9 Samples
Download data: TXT
Series
Accession:
GSE174173
ID:
200174173
3.

Liver gene expression profile of wild type, liver-specific PTEN KO, SCAP KO and PTEN/SCAP double KO mice.

(Submitter supplied) Nonalcoholic steatohepatitis (NASH), a severe form of nonalcoholic fatty liver disease, is characterized by hepatic steatosis and hepatocellular injury and progresses to cirrhosis and hepatocellular carcinoma. Sterol regulatory element-binding proteins (SREBPs) are master regulators of lipogenesis. Liver-specific PTEN knockout (KO) mice show constitutive upregulation of SREBP through PI3K-Akt pathway activation, leading to spontaneous fatty liver and subsequent HCC development. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: GCT
Series
Accession:
GSE169104
ID:
200169104
4.

GFP and mCherry gene expression at single cell level of all liver cell types from B6J mice

(Submitter supplied) Diacylglycerol acyltransferase (DGAT)-2 catalyzes the final step of triglyceride (TG) synthesis. DGAT2 deletion in mice lowers liver TGs and DGAT2 overexpression might have the opposite effect. Mouse DGAT2 was overexpressed in C57Bl/6J mice using adeno-associated virus 8 (AAV8 and AAV-DJ). The tissue specificity of AAV8 and AAV-DJ was first evaluated. To confirm that AAV8 and AAV-DJ only infected hepatocytes and not other cells in liver, we carried out single cell sequencing of liver cells isolated from mice infected with AAV8-mCherry and AAV-DJ-GFP. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
1 Sample
Download data: FA, FASTA, GTF, MTX, TSV, TXT
Series
Accession:
GSE250338
ID:
200250338
5.

Analysis of Wild Type and hepatocyte-specific CD36 knockout (CD36LKO) mice liver Transcriptomes under high fat diet (HFD)

(Submitter supplied) We generated hepatocyte-specific CD36 knockout (CD36LKO) mice to study in vivo effects of CD36 on de novo lipogenesis (DNL) under high fat diet (HFD). Lipid deposition and DNL were analyzed in primary hepatocytes isolated from CD36LKO mice or HepG2 cells with CD36 overexpression. RNA-sequence, co-immunoprecipitation and proximity ligation assay were carried out to determine its role in regulating DNL. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE191059
ID:
200191059
6.

Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis.

(Submitter supplied) Background and aims: NASH, characterized by inflammation and fibrosis, is emerging as a leading etiology of HCC. Lipidomics analyses in the liver have shown that the levels of polyunsaturated phosphatidylcholine (PC) are decreased in patients with NASH, but the roles of membrane PC composition in the pathogenesis of NASH have not been investigated. Lysophosphatidylcholine acyltransferase 3 (LPCAT3), a phospholipid (PL) remodeling enzyme that produces polyunsaturated PLs, is a major determinant of membrane PC content in the liver. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
18 Samples
Download data
Series
Accession:
GSE218075
ID:
200218075
7.

Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis [Lpcat3_OE]

(Submitter supplied) Nonalcoholic steatohepatitis (NASH), characterized by inflammation and fibrosis, is emerging as a leading etiology of hepatocellular carcinoma (HCC). However, the mechanisms underlying the pathogenesis of NASH are not well understood. Here, we show that membrane phospholipid (PL) composition determined by a remodeling process modulates the progression of NASH. The expression of lysophosphatidylcholine acyltransferase 3 (LPCAT3), a PL remodeling enzyme that produces polyunsaturated PLs, is dramatically suppressed in human NASH livers compared to controls. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data: CSV
Series
Accession:
GSE218074
ID:
200218074
8.

Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis [LKO_NASH]

(Submitter supplied) Nonalcoholic steatohepatitis (NASH), characterized by inflammation and fibrosis, is emerging as a leading etiology of hepatocellular carcinoma (HCC). However, the mechanisms underlying the pathogenesis of NASH are not well understood. Here, we show that membrane phospholipid (PL) composition determined by a remodeling process modulates the progression of NASH. The expression of lysophosphatidylcholine acyltransferase 3 (LPCAT3), a PL remodeling enzyme that produces polyunsaturated PLs, is dramatically suppressed in human NASH livers compared to controls. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
10 Samples
Download data: TXT
Series
Accession:
GSE218073
ID:
200218073
9.

Gene expression analysis of H1299 cells in response to the presence or absence of glutamine or glucose

(Submitter supplied) By a transcriptome analysis using RNA sequencing in H1299 cells, a non-small cell lung cancer cell line (NSCLC), we determined the response of lipogenic genes to absence vs. presence of glutamine (Gln) or glucose (Gluc). We found that neither glutamine nor glucose alone was able to activate the expression of genes regulating fatty acid and cholesterol synthesis, and uptake, including SREBF1, SREBF2, ACLY, ACACA, FASN, SCD1, HMGCR and LDLR, as compared to absence of both. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
15 Samples
Download data: TXT
Series
Accession:
GSE199089
ID:
200199089
10.

Global transcript analysis of livers of Lrh-1 K289R knockin mice under refed conditions

(Submitter supplied) Transcript data from liver receptor homolog-1 (LRH-1) WT and LRH-1 K289R livers from mice fasted for 24h followed by 6h refed. We used microarrays to detail the global program of gene expression underlying hepatic function under refed conditions.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE89877
ID:
200089877
11.

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL82 GPL83 GPL81
30 Samples
Download data: CEL
Series
Accession:
GSE102259
ID:
200102259
12.

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes [MG_U74Cv2]

(Submitter supplied) The synthesis of fatty acids and cholesterol is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. Their function in liver has been characterized in transgenic mice that overexpress each SREBP isoform and in mice that lack all three nuclear SREBPs because of gene knockout of SREBP cleavage-activating protein (SCAP) required for nuclear localization of SREBPs. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL83
10 Samples
Download data: CEL
Series
Accession:
GSE102258
ID:
200102258
13.

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes [MG_U74Bv2]

(Submitter supplied) The synthesis of fatty acids and cholesterol is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. Their function in liver has been characterized in transgenic mice that overexpress each SREBP isoform and in mice that lack all three nuclear SREBPs because of gene knockout of SREBP cleavage-activating protein (SCAP) required for nuclear localization of SREBPs. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL82
10 Samples
Download data: CEL
Series
Accession:
GSE102257
ID:
200102257
14.

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes [MG_U74Av2]

(Submitter supplied) The synthesis of fatty acids and cholesterol is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. Their function in liver has been characterized in transgenic mice that overexpress each SREBP isoform and in mice that lack all three nuclear SREBPs because of gene knockout of SREBP cleavage-activating protein (SCAP) required for nuclear localization of SREBPs. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
10 Samples
Download data: CEL
Series
Accession:
GSE102256
ID:
200102256
15.

Lipid signalling enforces functional specialization of Treg cells in tumours [scRNA-seq EAE]

(Submitter supplied) Metabolic reprogramming enforces Treg cell functional specialization in tumors by coordinating fatty acid biosynthesis and inhibitory receptor signaling pathways. These findings point to new avenues to selectively targeting intratumoral Treg cells for cancer therapy.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
2 Samples
Download data: TAR
Series
Accession:
GSE166159
ID:
200166159
16.

Lipid signalling enforces functional specialization of Treg cells in tumours

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL16570 GPL23038 GPL21103
41 Samples
Download data: CEL, TAR
Series
Accession:
GSE165259
ID:
200165259
17.

Lipid signalling enforces functional specialization of Treg cells in tumours [scRNA-seq]

(Submitter supplied) Metabolic reprogramming enforces Treg cell functional specialization in tumors by coordinating fatty acid biosynthesis and inhibitory receptor signaling pathways. These findings point to new avenues to selectively targeting intratumoral Treg cells for cancer therapy.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
4 Samples
Download data: TAR
Series
Accession:
GSE165258
ID:
200165258
18.

Lipid signalling enforces functional specialization of Treg cells in tumours [microarray #2]

(Submitter supplied) Metabolic reprogramming enforces Treg cell functional specialization in tumors by coordinating fatty acid biosynthesis and inhibitory receptor signaling pathways. These findings point to new avenues to selectively targeting intratumoral Treg cells for cancer therapy.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
10 Samples
Download data: CEL
Series
Accession:
GSE165257
ID:
200165257
19.

Lipid signalling enforces functional specialization of Treg cells in tumours [microarray #1]

(Submitter supplied) Metabolic reprogramming enforces Treg cell functional specialization in tumors by coordinating fatty acid biosynthesis and inhibitory receptor signaling pathways. These findings point to new avenues to selectively targeting intratumoral Treg cells for cancer therapy.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
25 Samples
Download data: CEL
Series
Accession:
GSE149573
ID:
200149573
20.

SREBP signaling is essential for effective B cell responses and memory formation

(Submitter supplied) To investigate the function of SREBP signaling in established germinal center B cells, we generated SCAP fl/fl AID-Cre-YFP mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of sorted germinal center B cells from immunized control and SCAP fl/fl AID-Cre-YFP mice
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
7 Samples
Download data: TXT
Series
Accession:
GSE206016
ID:
200206016
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