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    TSR3 ribosome biogenesis protein TSR3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854167, updated on 4-Jan-2025

    Summary

    Official Symbol
    TSR3
    Official Full Name
    ribosome biogenesis protein TSR3
    Primary source
    SGD:S000005532
    Locus tag
    YOR006C
    See related
    AllianceGenome:SGD:S000005532; FungiDB:YOR006C; VEuPathDB:YOR006C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 18S rRNA aminocarboxypropyltransferase activity. Involved in maturation of SSU-rRNA. Located in peroxisome. Orthologous to human TSR3 (TSR3 ribosome maturation factor). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See TSR3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (337680..338621, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene rRNA-binding ribosome biosynthesis protein UTP23 Neighboring gene DNA ligase (ATP) DNL4 Neighboring gene Sgt2p Neighboring gene tRNA-Arg

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in enzyme-directed rRNA pseudouridine synthesis  
    involved_in maturation of SSU-rRNA  
    involved_in maturation of SSU-rRNA PubMed 
    involved_in rRNA processing  
    involved_in ribosome biogenesis  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in peroxisome PubMed 

    General protein information

    Preferred Names
    ribosome biogenesis protein TSR3
    NP_014648.1
    • Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress; also detected in peroxisomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      337680..338621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183425.1 → NP_014648.1  TPA: ribosome biogenesis protein TSR3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014648.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W272, Q12094
      UniProtKB/TrEMBL
      A6ZNL1, B5VRQ8, C7GJU7
      Conserved Domains (3) summary
      COG2042
      Location:34 → 214
      Tsr3; Ribosome biogenesis protein Tsr3 (rRNA maturation) [Translation, ribosomal structure and biogenesis]
      pfam04034
      Location:84 → 208
      DUF367; Domain of unknown function (DUF367)
      pfam04068
      Location:46 → 80
      RLI; Possible Fer4-like domain in RNase L inhibitor, RLI
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