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    Opa1 Optic atrophy 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36578, updated on 17-Dec-2024

    Summary

    Official Symbol
    Opa1provided by FlyBase
    Official Full Name
    Optic atrophy 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0261276
    Locus tag
    Dmel_CG8479
    See related
    AllianceGenome:FB:FBgn0261276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8479; Dmel\CG8479; dOpa; dOpa1; dOPA1; l(2)s3475; opa1; OPA1; opa1-like; Opa1-like; OPA1-like
    Summary
    Predicted to enable GTPase activity and microtubule binding activity. Involved in compound eye morphogenesis; mitochondrial fusion; and positive regulation of mitochondrial fusion. Located in mitochondrion. Is expressed in adult head; adult heart; indirect flight muscle cell; and organism. Used to study optic atrophy. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Opa1 in Genome Data Viewer
    Location:
    50E4-50E4; 2-69 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14230611..14235449, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10118116..10122954, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Sox box protein 15 Neighboring gene mir-308 stem loop Neighboring gene Ribosomal protein S23 Neighboring gene uncharacterized protein Neighboring gene mir-1016 stem loop Neighboring gene SNF related kinase Neighboring gene Ubiquitin specific protease 20/33

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables microtubule binding  
    Process Evidence Code Pubs
    involved_in compound eye morphogenesis PubMed 
    involved_in endocytosis  
    involved_in intracellular distribution of mitochondria  
    involved_in mitochondrial fission  
    involved_in mitochondrial fusion  
    involved_in mitochondrial fusion PubMed 
    involved_in mitochondrion organization PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in peroxisome fission  
    involved_in positive regulation of mitochondrial fusion PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in microtubule  
    is_active_in mitochondrial intermembrane space  
    is_active_in mitochondrial membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    optic atrophy 1
    Names
    CG8479-PA
    CG8479-PB
    CG8479-PC
    CG8479-PD
    CG8479-PE
    Opa1-PA
    Opa1-PB
    Opa1-PC
    Opa1-PD
    Opa1-PE
    Opa1-like
    dOpa1
    drosophila optic atrophy 1-like
    lethal (2) s3475
    optic atrophy 1 ortholog
    optic atrophy 1-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14230611..14235449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299483.1 → NP_001286412.1  optic atrophy 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFB8, E8NH94
      Conserved Domains (1) summary
      cd08771
      Location:259 → 533
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    2. NM_137097.3 → NP_610941.1  optic atrophy 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH94, Q95U20
      Related
      FBpp0086699
      Conserved Domains (1) summary
      cd08771
      Location:259 → 533
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    3. NM_001299484.1 → NP_001286413.1  optic atrophy 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF33
      Conserved Domains (1) summary
      cd08771
      Location:259 → 533
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    4. NM_001299482.1 → NP_001286411.1  optic atrophy 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGF5, E8NH94
      Conserved Domains (1) summary
      cd08771
      Location:298 → 572
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    5. NM_166040.2 → NP_725369.1  optic atrophy 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725369.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9N0, E8NH94
      Related
      FBpp0086700
      Conserved Domains (1) summary
      cd08771
      Location:298 → 572
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
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