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    Ktn1 kinectin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ktn1provided by RGD
    Official Full Name
    kinectin 1provided by RGD
    Primary source
    RGD:1308719
    See related
    EnsemblRapid:ENSRNOG00000012255 AllianceGenome:RGD:1308719
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable kinesin binding activity. Predicted to be involved in microtubule-based movement and protein transport. Predicted to be located in endoplasmic reticulum. Orthologous to human KTN1 (kinectin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 235.1), Muscle (RPKM 222.5) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See Ktn1 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (23392570..23485061)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (20913665..21002588)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (24465761..24552833)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352900 Neighboring gene ATP synthase peripheral stalk-membrane subunit b, pseudogene 3 Neighboring gene U6 spliceosomal RNA Neighboring gene 5S ribosomal RNA Neighboring gene uncharacterized LOC134481957

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intact lysosome transport and phagosome function despite kinectin deficiency. Plitz T, et al. Mol Cell Biol, 2001 Sep. PMID 11486041, Free PMC Article
    2. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Cao Z, et al. Mol Cell Proteomics, 2008 Sep. PMID 18504258, Free PMC Article
    3. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Lin Z, et al. Aging Cell, 2021 Feb. PMID 33450132, Free PMC Article
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinesin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinectin
    Names
    kinectin 1 (kinesin receptor)

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      23392570..23485061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274792.1 → XP_063130862.1  kinectin isoform X23

      UniProtKB/TrEMBL
      A0A8I5Y832

    2. XM_039093793.2 → XP_038949721.1  kinectin isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1243
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    3. XM_039093792.2 → XP_038949720.1  kinectin isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1243
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    4. XM_063274787.1 → XP_063130857.1  kinectin isoform X9

      UniProtKB/TrEMBL
      A0A8I6ACR7

    5. XM_063274784.1 → XP_063130854.1  kinectin isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACR7

    6. XM_063274785.1 → XP_063130855.1  kinectin isoform X3

      UniProtKB/TrEMBL
      A0A8I6A4W2, A0A8I6ACR7

    7. XM_039093791.2 → XP_038949719.1  kinectin isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1243
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    8. XM_063274788.1 → XP_063130858.1  kinectin isoform X9

      UniProtKB/TrEMBL
      A0A8I6ACR7

    9. XM_039093797.2 → XP_038949725.1  kinectin isoform X6

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1243
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    10. XM_039093803.2 → XP_038949731.1  kinectin isoform X16

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (2) summary
      COG1196
      Location:332 → 1054
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    11. XM_063274790.1 → XP_063130860.1  kinectin isoform X17

      UniProtKB/TrEMBL
      A0A8I6ACR7

    12. XM_063274786.1 → XP_063130856.1  kinectin isoform X8

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Related
      ENSRNOP00000094260.2, ENSRNOT00000107795.2

    13. XM_006251824.5 → XP_006251886.1  kinectin isoform X18

      See identical proteins and their annotated locations for XP_006251886.1

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (2) summary
      TIGR02168
      Location:460 → 1243
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl23763
      Location:987 → 1176
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain

    14. XM_039093812.2 → XP_038949740.1  kinectin isoform X28

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1219
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    15. XM_039093807.2 → XP_038949735.1  kinectin isoform X20

      UniProtKB/TrEMBL
      A0A8I6ACR7, A0A8I6AJ62
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1242
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    16. XM_039093814.2 → XP_038949742.1  kinectin isoform X30

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (3) summary
      COG1196
      Location:332 → 1085
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
      NF033930
      Location:988 → 1200
      pneumo_PspA; pneumococcal surface protein A

    17. XM_039093813.2 → XP_038949741.1  kinectin isoform X29

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (2) summary
      COG1196
      Location:362 → 1206
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    18. XM_008770614.4 → XP_008768836.1  kinectin isoform X34

      See identical proteins and their annotated locations for XP_008768836.1

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (1) summary
      COG1196
      Location:332 → 1085
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    19. XM_039093802.2 → XP_038949730.1  kinectin isoform X15

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1215
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    20. XM_039093811.2 → XP_038949739.1  kinectin isoform X26

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1220
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    21. XM_039093810.2 → XP_038949738.1  kinectin isoform X25

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1173
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    22. XM_039093816.2 → XP_038949744.1  kinectin isoform X32

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1196
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    23. XM_063274793.1 → XP_063130863.1  kinectin isoform X27

      UniProtKB/TrEMBL
      A0A8I6ACR7

    24. XM_039093817.2 → XP_038949745.1  kinectin isoform X33

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1191
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    25. XM_039093820.2 → XP_038949748.1  kinectin isoform X36

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1161
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    26. XM_063274798.1 → XP_063130868.1  kinectin isoform X42

      UniProtKB/TrEMBL
      A0A8I5Y832

    27. XM_063274799.1 → XP_063130869.1  kinectin isoform X43

      UniProtKB/TrEMBL
      A0A8I5Y832

    28. XM_039093790.2 → XP_038949718.1  kinectin isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Related
      ENSRNOP00000089965.1, ENSRNOT00000099783.2
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1243
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    29. XM_039093800.2 → XP_038949728.1  kinectin isoform X10

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (2) summary
      COG1196
      Location:332 → 1054
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    30. XM_039093799.2 → XP_038949727.1  kinectin isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (2) summary
      COG1196
      Location:332 → 1054
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    31. XM_039093801.2 → XP_038949729.1  kinectin isoform X11

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Conserved Domains (3) summary
      COG1196
      Location:332 → 1090
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
      cl27170
      Location:1041 → 1189
      DUF460; Protein of unknown function (DUF460)

    32. XM_039093808.2 → XP_038949736.1  kinectin isoform X22

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (2) summary
      COG1196
      Location:332 → 1090
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    33. XM_039093796.2 → XP_038949724.1  kinectin isoform X5

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1220
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    34. XM_006251816.5 → XP_006251878.1  kinectin isoform X3

      See identical proteins and their annotated locations for XP_006251878.1

      UniProtKB/TrEMBL
      A0A8I6A4W2, A0A8I6ACR7
      Related
      ENSRNOP00000086218.1, ENSRNOT00000106317.2
      Conserved Domains (2) summary
      TIGR02168
      Location:460 → 1238
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl23763
      Location:987 → 1176
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain

    35. XM_006251822.5 → XP_006251884.1  kinectin isoform X13

      See identical proteins and their annotated locations for XP_006251884.1

      UniProtKB/TrEMBL
      A0A8I5Y832, D4A4Z9
      Related
      ENSRNOP00000016449.7, ENSRNOT00000016449.10
      Conserved Domains (2) summary
      TIGR02168
      Location:460 → 1243
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl23763
      Location:987 → 1176
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain

    36. XM_063274789.1 → XP_063130859.1  kinectin isoform X14

      UniProtKB/TrEMBL
      A0A8I6ACR7, A0A8I6AHJ4
      Related
      ENSRNOP00000092286.1, ENSRNOT00000097063.2

    37. XM_006251826.5 → XP_006251888.1  kinectin isoform X24

      See identical proteins and their annotated locations for XP_006251888.1

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (1) summary
      COG1196
      Location:332 → 1085
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    38. XM_006251819.5 → XP_006251881.1  kinectin isoform X9

      See identical proteins and their annotated locations for XP_006251881.1

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Related
      ENSRNOP00000092335.2, ENSRNOT00000119719.2
      Conserved Domains (2) summary
      TIGR02168
      Location:460 → 1215
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl23763
      Location:964 → 1153
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain

    39. XM_039093806.2 → XP_038949734.1  kinectin isoform X19

      UniProtKB/TrEMBL
      A0A8I5Y832, A0A8I6AVJ5
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1220
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    40. XM_063274791.1 → XP_063130861.1  kinectin isoform X21

      UniProtKB/TrEMBL
      A0A8I6ACR7

    41. XM_039093815.2 → XP_038949743.1  kinectin isoform X31

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1191
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    42. XM_039093818.2 → XP_038949746.1  kinectin isoform X35

      UniProtKB/TrEMBL
      A0A8I5Y832
      Conserved Domains (3) summary
      COG4372
      Location:343 → 521
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:460 → 1161
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    43. XM_039093795.2 → XP_038949723.1  kinectin isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACR7
      Conserved Domains (3) summary
      COG4372
      Location:341 → 519
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:458 → 1241
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05104
      Location:29 → 139
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    44. XM_017599845.3 → XP_017455334.1  kinectin isoform X4

      UniProtKB/TrEMBL
      A0A8I6ACR7

    45. XM_017599846.3 → XP_017455335.1  kinectin isoform X12

      UniProtKB/TrEMBL
      A0A8I6ACR7

    46. XM_017599848.3 → XP_017455337.1  kinectin isoform X38

      UniProtKB/TrEMBL
      A0A8I5Y832

    47. XM_017599849.3 → XP_017455338.1  kinectin isoform X40

      UniProtKB/TrEMBL
      A0A8I5Y832

    48. XM_063274796.1 → XP_063130866.1  kinectin isoform X39

      UniProtKB/TrEMBL
      A0A8I6ACR7

    49. XM_063274797.1 → XP_063130867.1  kinectin isoform X41

      UniProtKB/TrEMBL
      A0A8I6ACR7

    50. XM_063274795.1 → XP_063130865.1  kinectin isoform X37

      UniProtKB/TrEMBL
      A6KE57
    Nucleotide Protein Strain
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