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    NTE1 lysophospholipase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854943, updated on 9-Dec-2024

    Summary

    Official Symbol
    NTE1
    Official Full Name
    lysophospholipase
    Primary source
    SGD:S000004524
    Locus tag
    YML059C
    See related
    AllianceGenome:SGD:S000004524; FungiDB:YML059C; VEuPathDB:YML059C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lysophospholipase activity. Involved in phosphatidylcholine catabolic process and regulation of phospholipid biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to several human genes including PNPLA6 (patatin like phospholipase domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See NTE1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (153219..158258, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene DNA helicase PIF1 Neighboring gene 8-oxoguanine glycosylase OGG1 Neighboring gene Hug1p Neighboring gene ribonucleotide reductase inhibiting protein SML1

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity  
    enables lysophospholipase activity  
    enables lysophospholipase activity PubMed 
    enables lysophospholipase activity  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum PubMed 
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in lipid droplet  
    located_in membrane  

    General protein information

    Preferred Names
    lysophospholipase
    NP_013652.1
    • Serine esterase; homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      153219..158258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182418.1 → NP_013652.1  TPA: lysophospholipase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013652.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZB4, Q04958
      UniProtKB/TrEMBL
      B3LLJ6, N1NXX6
      Conserved Domains (3) summary
      cd07227
      Location:1361 → 1629
      Pat_Fungal_NTE1; Fungal patatin-like phospholipase domain containing protein 6
      cd00038
      Location:957 → 1067
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00027
      Location:821 → 933
      cNMP_binding; Cyclic nucleotide-binding domain
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