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Hecw Hecw ubiquitin protein ligase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31905, updated on 9-Dec-2024

Summary

Official Symbol
Hecwprovided by FlyBase
Official Full Name
Hecw ubiquitin protein ligaseprovided by FlyBase
Primary source
FLYBASE:FBgn0261931
Locus tag
Dmel_CG42797
See related
AllianceGenome:FB:FBgn0261931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797
Old locus tag
Dmel_CG3003; Dmel_CG3099
Summary
Enables ubiquitin protein ligase activity. Involved in protein K63-linked ubiquitination. Is active in cytosol. Orthologous to several human genes including HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Hecw in Genome Data Viewer
Location:
8F1-8F2; 1-29 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9608946..9623243)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9502979..9517276)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Golgi-localized, gamma-adaptin ear containing, ARF binding protein Neighboring gene Lst8 Neighboring gene Lysyl-tRNA synthetase Neighboring gene Protein tyrosine phosphatase Meg2 Neighboring gene uncharacterized protein Neighboring gene nejire

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity  
enables ubiquitin protein ligase activity PubMed 
enables ubiquitin protein ligase activity  
enables ubiquitin-protein transferase activity  
Process Evidence Code Pubs
involved_in protein K63-linked ubiquitination PubMed 
involved_in protein ubiquitination  
involved_in regulation of dendrite morphogenesis  
involved_in ubiquitin-dependent protein catabolic process  
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in cytosol PubMed 

General protein information

Preferred Names
hecw ubiquitin protein ligase
Names
CG42797-PC
CG42797-PD
CG42797-PE
CG42797-PF
Hecw-PC
Hecw-PD
Hecw-PE
Hecw-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9608946..9623243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201643.2 → NP_001188572.1  hecw ubiquitin protein ligase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188572.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MS90
    Conserved Domains (3) summary
    smart00119
    Location:1089 → 1420
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1065 → 1421
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:635 → 664
    WW; WW domain
  2. NM_132346.3 → NP_572574.2  hecw ubiquitin protein ligase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572574.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H5V8D8, Q9W326
    Conserved Domains (3) summary
    smart00119
    Location:1092 → 1423
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1068 → 1424
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:638 → 667
    WW; WW domain
  3. NM_001272456.1 → NP_001259385.1  hecw ubiquitin protein ligase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259385.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6IDU1, D5SHR3
    Conserved Domains (1) summary
    cd00078
    Location:76 → 432
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  4. NM_132347.2 → NP_572575.2  hecw ubiquitin protein ligase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572575.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6IDU1, Q9W325
    Conserved Domains (2) summary
    smart00119
    Location:102 → 433
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:78 → 434
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
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