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    VPS41 Vps41p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851653, updated on 9-Dec-2024

    Summary

    Official Symbol
    VPS41
    Official Full Name
    Vps41p
    Primary source
    SGD:S000002487
    Locus tag
    YDR080W
    See related
    AllianceGenome:SGD:S000002487; FungiDB:YDR080W; VEuPathDB:YDR080W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CVT8; FET2; SVL2; VAM2; VPL20
    Summary
    Enables small GTPase binding activity. Contributes to phosphatidylinositol binding activity. Involved in several processes, including piecemeal microautophagy of the nucleus; vacuolar protein processing; and vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane. Part of HOPS complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 29. Orthologous to human VPS41 (VPS41 subunit of HOPS complex). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See VPS41 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (604008..606986)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pet100p Neighboring gene TFIIH complex subunit TFB5 Neighboring gene Pdc2p Neighboring gene Stn1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in cellular response to starvation  
    involved_in cytoplasm to vacuole targeting by the Cvt pathway PubMed 
    involved_in endosomal vesicle fusion  
    involved_in endosomal vesicle fusion  
    involved_in macroautophagy  
    involved_in macroautophagy PubMed 
    involved_in piecemeal microautophagy of the nucleus PubMed 
    involved_in protein targeting to vacuole  
    involved_in protein targeting to vacuole  
    involved_in protein transport  
    involved_in protein transport PubMed 
    involved_in regulation of SNARE complex assembly PubMed 
    involved_in vacuolar protein processing PubMed 
    involved_in vacuole fusion, non-autophagic PubMed 
    involved_in vacuole fusion, non-autophagic PubMed 
    involved_in vacuole organization PubMed 
    involved_in vesicle tethering PubMed 
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport PubMed 
    Component Evidence Code Pubs
    part_of HOPS complex  
    part_of HOPS complex PubMed 
    located_in bounding membrane of organelle  
    located_in endosome PubMed 
    located_in fungal-type vacuole membrane PubMed 
    located_in fungal-type vacuole membrane PubMed 
    is_active_in late endosome  
    located_in vacuole  

    General protein information

    Preferred Names
    Vps41p
    NP_010365.3
    • Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting specifically with the GTP-bound conformation of Ypt7p, facilitating tethering, docking and promoting membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; Yck3p-mediated phosphorylation regulates the organization of vacuolar fusion sites

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      604008..606986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180388.3NP_010365.3  TPA: Vps41p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010365.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS67, P38959, P87334, Q12011
      UniProtKB/TrEMBL
      A6ZY46, C7GVQ6, N1P4N1
      Conserved Domains (2) summary
      smart00299
      Location:753896
      CLH; Clathrin heavy chain repeat homology
      smart00320
      Location:145179
      WD40; WD40 repeats
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