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    CCC2 Cu(2+)-transporting P-type ATPase CCC2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851862, updated on 9-Dec-2024

    Summary

    Official Symbol
    CCC2
    Official Full Name
    Cu(2+)-transporting P-type ATPase CCC2
    Primary source
    SGD:S000002678
    Locus tag
    YDR270W
    See related
    AllianceGenome:SGD:S000002678; FungiDB:YDR270W; VEuPathDB:YDR270W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATPase-coupled monoatomic cation transmembrane transporter activity and copper ion binding activity. Involved in copper ion export and intracellular iron ion homeostasis. Located in trans-Golgi network transport vesicle membrane. Used to study Menkes disease; Wilson disease; occipital horn syndrome; and spinal muscular atrophy. Human ortholog(s) of this gene implicated in Menkes disease; Wilson disease; X-linked distal spinal muscular atrophy 3; cutis laxa; and occipital horn syndrome. Orthologous to several human genes including ATP7A (ATPase copper transporting alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See CCC2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1005675..1008689)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly protein CIA1 Neighboring gene tryptophan--tRNA ligase MSW1 Neighboring gene hydroxyacylglutathione hydrolase GLO2 Neighboring gene Don1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in copper ion export PubMed 
    involved_in copper ion homeostasis  
    involved_in copper ion transport  
    involved_in intracellular iron ion homeostasis PubMed 
    involved_in monoatomic cation transport  
    involved_in transmembrane transport PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in membrane  
    located_in membrane  
    located_in trans-Golgi network transport vesicle membrane PubMed 

    General protein information

    Preferred Names
    Cu(2+)-transporting P-type ATPase CCC2
    NP_010556.1
    • Cu(+2)-transporting P-type ATPase; required for export of copper from cytosol into extracytosolic compartment; targeted to vacuole via AP-3 pathway; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1005675..1008689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180578.1 → NP_010556.1  TPA: Cu(2+)-transporting P-type ATPase CCC2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010556.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSQ3, P38995
      UniProtKB/TrEMBL
      B3LG21, C7GS90, C8Z5I3, N1P708
      Conserved Domains (2) summary
      cd00371
      Location:6 → 67
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      cd02094
      Location:259 → 938
      P-type_ATPase_Cu-like; P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B
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