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    STB5 Stb5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856583, updated on 9-Dec-2024

    Summary

    Official Symbol
    STB5
    Official Full Name
    Stb5p
    Primary source
    SGD:S000001221
    Locus tag
    YHR178W
    See related
    AllianceGenome:SGD:S000001221; FungiDB:YHR178W; VEuPathDB:YHR178W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor activity. Involved in cellular response to oxidative stress; regulation of transcription by RNA polymerase II; and transcription elongation by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See STB5 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (459299..461530)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene N,N-dimethylaniline monooxygenase Neighboring gene Rof1p Neighboring gene NADPH dehydrogenase Neighboring gene uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    Stb5p
    NP_012048.3
    • Transcription factor; regulates multidrug resistance and the oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro; negative regulator of autophagy, modulating the transcription of genes involved in NADPH production and the pentose phosphate pathway; Stb5p expression is reduced during nitrogen starvation and autophagy induction, while STB5 mRNA levels are significantly increased

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      459299..461530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179309.3 → NP_012048.3  TPA: Stb5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012048.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLC7, P38699
      UniProtKB/TrEMBL
      A6ZT85, C7GW81, G2WFQ2, N1P2H2
      Conserved Domains (2) summary
      cd12148
      Location:293 → 699
      fungal_TF_MHR; fungal transcription factor regulatory middle homology region
      pfam00172
      Location:20 → 58
      Zn_clus; Fungal Zn(2)-Cys(6) binuclear cluster domain
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