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Disorder of testis

MedGen UID:
11743
•Concept ID:
C0039584
•
Disease or Syndrome
Synonyms: Testicular disease; Testicular disorder
SNOMED CT: Disorder of testis (64910008); Testicular disorder (64910008); Testicular disease (236763001)
 
Monarch Initiative: MONDO:0002329

Definition

A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of testis

Professional guidelines

PubMed

Advances in diagnosis and treatment of testicular cancer.
Chovanec M, Cheng L
BMJ 2022 Nov 28;379:e070499. doi: 10.1136/bmj-2022-070499. PMID: 36442868
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

Management of Testicular Microlithiasis.
Dinkelman-Smit M
Eur Urol Focus 2021 Sep;7(5):940-942. Epub 2021 Sep 29 doi: 10.1016/j.euf.2021.09.020. PMID: 34598911
The Application Value of Contrast-Enhanced Ultrasound in Testicular Occupied Lesions.
Liu Q, Gong H, Zhu H, Yuan C, Hu B
Comput Math Methods Med 2021;2021:9962970. Epub 2021 Jun 11 doi: 10.1155/2021/9962970. PMID: 34194540Free PMC Article
Testicular epidermoid cyst.
Çakıroğlu B, Sönmez NC, Sinanoğlu O, Ateş L, Aksoy SH, Özcan F
Afr J Paediatr Surg 2015 Jan-Mar;12(1):89-90. doi: 10.4103/0189-6725.151002. PMID: 25659561Free PMC Article
Orchialgia after orchiectomy.
Dellon AL, Hashemi SS, Tollstrupt TH
Plast Reconstr Surg 2014 Dec;134(6):998e-999e. doi: 10.1097/PRS.0000000000000726. PMID: 25415132
Cryptorchidism.
Lee PA, Houk CP
Curr Opin Endocrinol Diabetes Obes 2013 Jun;20(3):210-6. doi: 10.1097/MED.0b013e32835ffc7d. PMID: 23493040

Diagnosis

Male infertility due to testicular disorders.
Sharma A, Minhas S, Dhillo WS, Jayasena CN
J Clin Endocrinol Metab 2021 Jan 23;106(2):e442-e459. doi: 10.1210/clinem/dgaa781. PMID: 33295608Free PMC Article
Acute Scrotal Emergencies.
Bourke MM, Silverberg JZ
Emerg Med Clin North Am 2019 Nov;37(4):593-610. Epub 2019 Aug 24 doi: 10.1016/j.emc.2019.07.002. PMID: 31563197
Scrotal Ultrasound.
Rebik K, Wagner JM, Middleton W
Radiol Clin North Am 2019 May;57(3):635-648. Epub 2019 Feb 14 doi: 10.1016/j.rcl.2019.01.007. PMID: 30928082
The diagnosis and management of scrotal masses.
Montgomery JS, Bloom DA
Med Clin North Am 2011 Jan;95(1):235-44. doi: 10.1016/j.mcna.2010.08.029. PMID: 21095426
Diagnosing testicular pain.
Kapoor S, Nargund VH
Practitioner 2002 Dec;246(1641):792-4, 799-800. PMID: 12489355

Therapy

Risk Factors for Testicular Cancer: Environment, Genes and Infections-Is It All?
Yazici S, Del Biondo D, Napodano G, Grillo M, Calace FP, Prezioso D, Crocetto F, Barone B
Medicina (Kaunas) 2023 Apr 7;59(4) doi: 10.3390/medicina59040724. PMID: 37109682Free PMC Article
Basic concepts and recent advancements in the study of male fertility.
Kovac JR, Lipshultz LI
Asian J Androl 2016 May-Jun;18(3):331. doi: 10.4103/1008-682X.179141. PMID: 27048783Free PMC Article
Maldescendus testis.
Toppari J, Kaleva M
Horm Res 1999 Dec;51(6):261-9. doi: 10.1159/000023412. PMID: 10640886
Henoch-Schönlein purpura.
Robson WL, Leung AK
Adv Pediatr 1994;41:163-94. PMID: 7992683
The effects of cancer and cancer therapy on male reproductive function.
Costabile RA
J Urol 1993 May;149(5 Pt 2):1327-30. doi: 10.1016/s0022-5347(17)36384-x. PMID: 8479029

Prognosis

Management of Undescended Testis: A Debate.
Bertelloni S, Wünsch L
Sex Dev 2019;13(1):1-2. Epub 2019 Jan 22 doi: 10.1159/000496464. PMID: 30665227
Editorial.
Rogers BB
Pediatr Dev Pathol 2015 Mar-Apr;18(2):87. doi: 10.2350/18-02-Editorial.1. PMID: 25870902
Testicular epidermoid cyst.
Çakıroğlu B, Sönmez NC, Sinanoğlu O, Ateş L, Aksoy SH, Özcan F
Afr J Paediatr Surg 2015 Jan-Mar;12(1):89-90. doi: 10.4103/0189-6725.151002. PMID: 25659561Free PMC Article
Testicular cancer: overview and implications for health care providers.
Russell SS
Urol Nurs 2014 Jul-Aug;34(4):172-6, 192. PMID: 25233618
Physiology and disorders of testicular descent.
Toppari J
Endocr Dev 2003;5:104-9. doi: 10.1159/000069297. PMID: 12629894

Clinical prediction guides

High risk and low prevalence diseases: Testicular torsion.
Lacy A, Smith A, Koyfman A, Long B
Am J Emerg Med 2023 Apr;66:98-104. Epub 2023 Jan 24 doi: 10.1016/j.ajem.2023.01.031. PMID: 36738571
RE: The value of testicular ultrasound in the prediction of the type and size of testicular tumors.
Kamarulzaman MN, Mohamed SK
Int Braz J Urol 2016 Mar-Apr;42(2):397-8. doi: 10.1590/S1677-5538.IBJU.2015.0728. PMID: 27256199Free PMC Article
Editorial.
Rogers BB
Pediatr Dev Pathol 2015 Mar-Apr;18(2):87. doi: 10.2350/18-02-Editorial.1. PMID: 25870902
Maldescendus testis.
Toppari J, Kaleva M
Horm Res 1999 Dec;51(6):261-9. doi: 10.1159/000023412. PMID: 10640886
Role of epididymis in sperm maturation.
Silber SJ
Urology 1989 Jan;33(1):47-51. doi: 10.1016/0090-4295(89)90066-6. PMID: 2911926

Recent systematic reviews

Per- and Poly-fluoroalkyl Substances (PFAS) Exposure and Risk of Kidney, Liver, and Testicular Cancers: A Systematic Review and Meta-Analysis.
Seyyedsalehi MS, Boffetta P
Med Lav 2023 Oct 24;114(5):e2023040. doi: 10.23749/mdl.v114i5.15065. PMID: 37878255Free PMC Article
Lifestyle-, environmental-, and additional health factors associated with an increased sperm DNA fragmentation: a systematic review and meta-analysis.
Szabó A, Váncsa S, Hegyi P, Váradi A, Forintos A, Filipov T, Ács J, Ács N, Szarvas T, Nyirády P, Kopa Z
Reprod Biol Endocrinol 2023 Jan 18;21(1):5. doi: 10.1186/s12958-023-01054-0. PMID: 36653793Free PMC Article
Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis.
Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC
Am J Obstet Gynecol 2022 Sep;227(3):414-429.e17. Epub 2022 Mar 30 doi: 10.1016/j.ajog.2022.03.052. PMID: 35367190
KRAS and BRAF Mutations in Stage II and III Colon Cancer: A Systematic Review and Meta-Analysis.
Formica V, Sera F, Cremolini C, Riondino S, Morelli C, Arkenau HT, Roselli M
J Natl Cancer Inst 2022 Apr 11;114(4):517-527. doi: 10.1093/jnci/djab190. PMID: 34542636Free PMC Article
A Systematic Review on the Use of Qualitative and Quantitative Contrast-enhanced Ultrasound in Diagnosing Testicular Abnormalities.
Pinto SPS, Huang DY, Dinesh AA, Sidhu PS, Ahmed K
Urology 2021 Aug;154:16-23. Epub 2021 Feb 20 doi: 10.1016/j.urology.2021.02.012. PMID: 33621585

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