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Mesonephric adenocarcinoma

MedGen UID:
44373
•Concept ID:
C0025490
•
Neoplastic Process
Synonyms: Mesonephroma; Mesonephromas
SNOMED CT: Malignant mesonephroma (2221008); Mesonephroma, malignant (2221008); Mesonephric adenocarcinoma (2221008); Wolffian duct carcinoma (2221008)
 
Monarch Initiative: MONDO:0005613

Definition

An adenocarcinoma of the cervix or the vagina that derives from Wolffian duct remnants and shows mesonephric differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesonephric adenocarcinoma

Professional guidelines

PubMed

Mesonephric and mesonephric-like adenocarcinomas of gynecologic origin: A single-center experience with molecular characterization, treatment, and oncologic outcomes.
Praiss AM, White C, Iasonos A, Selenica P, Zivanovic O, Chi DS, Abu-Rustum NR, Weigelt B, Aghajanian C, Girshman J, Park KJ, Grisham RN
Gynecol Oncol 2024 Mar;182:32-38. Epub 2024 Jan 20 doi: 10.1016/j.ygyno.2024.01.015. PMID: 38246044Free PMC Article
Uncommon Cervical Lesions: A Review and Discussion of the Differential Diagnosis.
Griesinger LM, Szczepanski JM, McMullen ER, Skala SL
Arch Pathol Lab Med 2021 Jul 1;145(7):891-902. doi: 10.5858/arpa.2020-0327-RA. PMID: 33091926

Recent clinical studies

Etiology

New clinicopathological concept of endometrial carcinoma with integration of histological features and molecular profiles.
Yasuda M
Pathol Int 2024 Oct;74(10):557-573. Epub 2024 Aug 22 doi: 10.1111/pin.13471. PMID: 39175262Free PMC Article
Mesonephric and mesonephric-like adenocarcinomas of gynecologic origin: A single-center experience with molecular characterization, treatment, and oncologic outcomes.
Praiss AM, White C, Iasonos A, Selenica P, Zivanovic O, Chi DS, Abu-Rustum NR, Weigelt B, Aghajanian C, Girshman J, Park KJ, Grisham RN
Gynecol Oncol 2024 Mar;182:32-38. Epub 2024 Jan 20 doi: 10.1016/j.ygyno.2024.01.015. PMID: 38246044Free PMC Article
Mesonephric-like adenocarcinoma harbours characteristic copy number variations and a distinct DNA methylation signature closely related to mesonephric adenocarcinoma of the cervix.
Kommoss FK, Lee CH, Tessier-Cloutier B, Gilks CB, Stewart CJ, von Deimling A, Köbel M
J Pathol 2024 Jan;262(1):4-9. Epub 2023 Oct 18 doi: 10.1002/path.6217. PMID: 37850576
Clinicopathologic Characteristics of Mesonephric Adenocarcinomas and Mesonephric-like Adenocarcinomas in the Gynecologic Tract: A Multi-institutional Study.
Pors J, Segura S, Chiu DS, Almadani N, Ren H, Fix DJ, Howitt BE, Kolin D, McCluggage WG, Mirkovic J, Gilks B, Park KJ, Hoang L
Am J Surg Pathol 2021 Apr 1;45(4):498-506. doi: 10.1097/PAS.0000000000001612. PMID: 33165093Free PMC Article
Recent Developments in Non-HPV-related Adenocarcinomas of the Lower Female Genital Tract and Their Precursors.
McCluggage WG
Adv Anat Pathol 2016 Jan;23(1):58-69. doi: 10.1097/PAP.0000000000000095. PMID: 26645463

Diagnosis

Malignant mesonephric tumor of the cervix with an initial manifestation as pulmonary metastasis: case report and review of the literature.
Yeo MK, Choi SY, Kim M, Kim KH, Suh KS
Eur J Gynaecol Oncol 2016;37(2):270-7. PMID: 27172762
Mesonephric adenocarcinoma of the vaginal-urethral interspace.
Yao Y, Han J, Liu C
Chin Med J (Engl) 2014;127(5):984-5. PMID: 24571903
Mesonephric adenocarcinoma of the cervix: a case report and review of the literature.
Yap OW, Hendrickson MR, Teng NN, Kapp DS
Gynecol Oncol 2006 Dec;103(3):1155-8. Epub 2006 Oct 4 doi: 10.1016/j.ygyno.2006.08.031. PMID: 17023031
Mesonephric adenocarcinoma of bladder.
Minervini R, Urbano U, Fiorentini L
Eur Urol 1984;10(2):141-2. doi: 10.1159/000463773. PMID: 6705819
MESONEPHRIC ADENOCARCINOMA AND ADENOMA OF THE CERVIX.
TOTH F, CSOEMOER S, MESZAROS J
Am J Obstet Gynecol 1964 Feb 15;88:452-9. doi: 10.1016/0002-9378(64)90502-2. PMID: 14123424

Therapy

Mesonephric adenocarcinoma in the uterine corpus: A case report and review of the literature.
Tang X, Li L, He Y
Indian J Pathol Microbiol 2021 Oct-Dec;64(4):806-809. doi: 10.4103/IJPM.IJPM_298_20. PMID: 34673610
Activity of chemotherapy with carboplatin plus paclitaxel in a recurrent mesonephric adenocarcinoma of the uterine corpus.
Montagut C, Mármol M, Rey V, Ordi J, Pahissa J, Rovirosa A, Gascón P, Mellado B
Gynecol Oncol 2003 Aug;90(2):458-61. doi: 10.1016/s0090-8258(03)00228-2. PMID: 12893219
Clear cell (mesonephric) adenocarcinoma of the vagina. A case report.
Rosati LA, Jarzynski DJ
Acta Cytol 1973 Nov-Dec;17(6):493-7. PMID: 4127770

Prognosis

New clinicopathological concept of endometrial carcinoma with integration of histological features and molecular profiles.
Yasuda M
Pathol Int 2024 Oct;74(10):557-573. Epub 2024 Aug 22 doi: 10.1111/pin.13471. PMID: 39175262Free PMC Article
Gastric-type Adenocarcinoma of the Cervix: Tumor With Wide Range of Histologic Appearances.
Pirog EC, Park KJ, Kiyokawa T, Zhang X, Chen W, Jenkins D, Quint W
Adv Anat Pathol 2019 Jan;26(1):1-12. doi: 10.1097/PAP.0000000000000216. PMID: 30234500
Clinicopathologic and Molecular Characteristics of Mesonephric Adenocarcinoma Arising From the Uterine Body.
Na K, Kim HS
Am J Surg Pathol 2019 Jan;43(1):12-25. doi: 10.1097/PAS.0000000000000991. PMID: 29189288Free PMC Article
Mesonephric adenocarcinoma of the vagina masquerading as a suburethral cyst.
Shoeir S, Balachandran AA, Wang J, Sultan AH
BMJ Case Rep 2018 Jul 3;2018 doi: 10.1136/bcr-2018-224758. PMID: 29970606Free PMC Article
Mesonephric adenocarcinoma of the vagina : Diagnosis and multimodal treatment of a rare tumor and analysis of worldwide experience.
Mueller I, Kametriser G, Jacobs VR, Bogner G, Staudach A, Koch H, Wolfrum-Ristau P, Schausberger C, Fischer T, Sedlmayer F
Strahlenther Onkol 2016 Sep;192(9):668-71. Epub 2016 Jun 27 doi: 10.1007/s00066-016-1004-x. PMID: 27349710Free PMC Article

Clinical prediction guides

Mesonephric adenocarcinoma in the uterine corpus: A case report and review of the literature.
Tang X, Li L, He Y
Indian J Pathol Microbiol 2021 Oct-Dec;64(4):806-809. doi: 10.4103/IJPM.IJPM_298_20. PMID: 34673610
Uncommon Cervical Lesions: A Review and Discussion of the Differential Diagnosis.
Griesinger LM, Szczepanski JM, McMullen ER, Skala SL
Arch Pathol Lab Med 2021 Jul 1;145(7):891-902. doi: 10.5858/arpa.2020-0327-RA. PMID: 33091926
Uterine lesions with sex cord-like architectures: a systematic review.
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article
Clinicopathologic and Molecular Characteristics of Mesonephric Adenocarcinoma Arising From the Uterine Body.
Na K, Kim HS
Am J Surg Pathol 2019 Jan;43(1):12-25. doi: 10.1097/PAS.0000000000000991. PMID: 29189288Free PMC Article
Mesonephric Adenocarcinoma of the Uterine Corpus: A Case Report and Diagnostic Pitfall.
Kim SS, Nam JH, Kim GE, Choi YD, Choi C, Park CS
Int J Surg Pathol 2016 Apr;24(2):153-8. Epub 2015 Oct 27 doi: 10.1177/1066896915611489. PMID: 26510860

Recent systematic reviews

Uterine lesions with sex cord-like architectures: a systematic review.
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article

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