dbSNP Short Genetic Variations
Welcome to the Reference SNP (rs) Report
All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.
Reference SNP (rs) Report
This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.
rs1205
Current Build 156
Released September 21, 2022
- Organism
- Homo sapiens
- Position
-
chr1:159712443 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
- Alleles
- C>T
- Variation Type
- SNV Single Nucleotide Variation
- Frequency
-
T=0.304617 (80629/264690, TOPMED)T=0.327486 (57758/176368, ALFA)T=0.304821 (42667/139974, GnomAD) (+ 20 more)
- Clinical Significance
- Reported in ClinVar
- Gene : Consequence
- CRP : 3 Prime UTR Variant
- Publications
- 173 citations
- Genomic View
- See rs on genome
ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.
Release Version: 20231103111315
| Population | Group | Sample Size | Ref Allele | Alt Allele | Ref HMOZ | Alt HMOZ | HTRZ | HWEP |
|---|---|---|---|---|---|---|---|---|
| Total | Global | 176462 | C=0.672513 | T=0.327487 | 0.454625 | 0.109599 | 0.435777 | 6 |
| European | Sub | 151814 | C=0.667830 | T=0.332170 | 0.447087 | 0.111426 | 0.441488 | 1 |
| African | Sub | 9746 | C=0.7984 | T=0.2016 | 0.640468 | 0.04371 | 0.315822 | 1 |
| African Others | Sub | 326 | C=0.850 | T=0.150 | 0.717791 | 0.018405 | 0.263804 | 0 |
| African American | Sub | 9420 | C=0.7966 | T=0.2034 | 0.637792 | 0.044586 | 0.317622 | 1 |
| Asian | Sub | 710 | C=0.403 | T=0.597 | 0.183099 | 0.377465 | 0.439437 | 2 |
| East Asian | Sub | 578 | C=0.391 | T=0.609 | 0.179931 | 0.397924 | 0.422145 | 2 |
| Other Asian | Sub | 132 | C=0.455 | T=0.545 | 0.19697 | 0.287879 | 0.515152 | 0 |
| Latin American 1 | Sub | 750 | C=0.667 | T=0.333 | 0.450667 | 0.117333 | 0.432 | 0 |
| Latin American 2 | Sub | 6318 | C=0.6379 | T=0.3621 | 0.399177 | 0.123457 | 0.477366 | 2 |
| South Asian | Sub | 192 | C=0.688 | T=0.312 | 0.489583 | 0.114583 | 0.395833 | 0 |
| Other | Sub | 6932 | C=0.6575 | T=0.3425 | 0.436238 | 0.121177 | 0.442585 | 1 |
Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").
Download| Study | Population | Group | Sample Size | Ref Allele | Alt Allele |
|---|---|---|---|---|---|
| TopMed | Global | Study-wide | 264690 | C=0.695383 | T=0.304617 |
| Allele Frequency Aggregator | Total | Global | 176368 | C=0.672514 | T=0.327486 |
| Allele Frequency Aggregator | European | Sub | 151738 | C=0.667835 | T=0.332165 |
| Allele Frequency Aggregator | African | Sub | 9746 | C=0.7984 | T=0.2016 |
| Allele Frequency Aggregator | Other | Sub | 6914 | C=0.6574 | T=0.3426 |
| Allele Frequency Aggregator | Latin American 2 | Sub | 6318 | C=0.6379 | T=0.3621 |
| Allele Frequency Aggregator | Latin American 1 | Sub | 750 | C=0.667 | T=0.333 |
| Allele Frequency Aggregator | Asian | Sub | 710 | C=0.403 | T=0.597 |
| Allele Frequency Aggregator | South Asian | Sub | 192 | C=0.688 | T=0.312 |
| gnomAD - Genomes | Global | Study-wide | 139974 | C=0.695179 | T=0.304821 |
| gnomAD - Genomes | European | Sub | 75798 | C=0.66225 | T=0.33775 |
| gnomAD - Genomes | African | Sub | 41952 | C=0.80225 | T=0.19775 |
| gnomAD - Genomes | American | Sub | 13634 | C=0.62601 | T=0.37399 |
| gnomAD - Genomes | Ashkenazi Jewish | Sub | 3320 | C=0.6392 | T=0.3608 |
| gnomAD - Genomes | East Asian | Sub | 3120 | C=0.4385 | T=0.5615 |
| gnomAD - Genomes | Other | Sub | 2150 | C=0.6647 | T=0.3353 |
| The PAGE Study | Global | Study-wide | 78698 | C=0.66572 | T=0.33428 |
| The PAGE Study | AfricanAmerican | Sub | 32516 | C=0.79635 | T=0.20365 |
| The PAGE Study | Mexican | Sub | 10810 | C=0.64829 | T=0.35171 |
| The PAGE Study | Asian | Sub | 8316 | C=0.3349 | T=0.6651 |
| The PAGE Study | PuertoRican | Sub | 7918 | C=0.6636 | T=0.3364 |
| The PAGE Study | NativeHawaiian | Sub | 4534 | C=0.3386 | T=0.6614 |
| The PAGE Study | Cuban | Sub | 4228 | C=0.6805 | T=0.3195 |
| The PAGE Study | Dominican | Sub | 3828 | C=0.7231 | T=0.2769 |
| The PAGE Study | CentralAmerican | Sub | 2450 | C=0.6563 | T=0.3437 |
| The PAGE Study | SouthAmerican | Sub | 1982 | C=0.6266 | T=0.3734 |
| The PAGE Study | NativeAmerican | Sub | 1260 | C=0.6587 | T=0.3413 |
| The PAGE Study | SouthAsian | Sub | 856 | C=0.689 | T=0.311 |
| 14KJPN | JAPANESE | Study-wide | 28256 | C=0.31774 | T=0.68226 |
| 8.3KJPN | JAPANESE | Study-wide | 16760 | C=0.32130 | T=0.67870 |
| 1000Genomes_30x | Global | Study-wide | 6404 | C=0.6652 | T=0.3348 |
| 1000Genomes_30x | African | Sub | 1786 | C=0.8270 | T=0.1730 |
| 1000Genomes_30x | Europe | Sub | 1266 | C=0.6801 | T=0.3199 |
| 1000Genomes_30x | South Asian | Sub | 1202 | C=0.6647 | T=0.3353 |
| 1000Genomes_30x | East Asian | Sub | 1170 | C=0.4359 | T=0.5641 |
| 1000Genomes_30x | American | Sub | 980 | C=0.626 | T=0.374 |
| 1000Genomes | Global | Study-wide | 5008 | C=0.6617 | T=0.3383 |
| 1000Genomes | African | Sub | 1322 | C=0.8298 | T=0.1702 |
| 1000Genomes | East Asian | Sub | 1008 | C=0.4335 | T=0.5665 |
| 1000Genomes | Europe | Sub | 1006 | C=0.6899 | T=0.3101 |
| 1000Genomes | South Asian | Sub | 978 | C=0.667 | T=0.333 |
| 1000Genomes | American | Sub | 694 | C=0.625 | T=0.375 |
| Genetic variation in the Estonian population | Estonian | Study-wide | 4480 | C=0.6132 | T=0.3868 |
| The Avon Longitudinal Study of Parents and Children | PARENT AND CHILD COHORT | Study-wide | 3854 | C=0.6718 | T=0.3282 |
| UK 10K study - Twins | TWIN COHORT | Study-wide | 3708 | C=0.6691 | T=0.3309 |
| KOREAN population from KRGDB | KOREAN | Study-wide | 2930 | C=0.3734 | T=0.6266 |
| HapMap | Global | Study-wide | 1892 | C=0.6718 | T=0.3282 |
| HapMap | American | Sub | 770 | C=0.617 | T=0.383 |
| HapMap | African | Sub | 692 | C=0.834 | T=0.166 |
| HapMap | Asian | Sub | 254 | C=0.374 | T=0.626 |
| HapMap | Europe | Sub | 176 | C=0.705 | T=0.295 |
| Genome-wide autozygosity in Daghestan | Global | Study-wide | 1134 | C=0.7240 | T=0.2760 |
| Genome-wide autozygosity in Daghestan | Daghestan | Sub | 626 | C=0.757 | T=0.243 |
| Genome-wide autozygosity in Daghestan | Near_East | Sub | 144 | C=0.688 | T=0.312 |
| Genome-wide autozygosity in Daghestan | Central Asia | Sub | 122 | C=0.582 | T=0.418 |
| Genome-wide autozygosity in Daghestan | Europe | Sub | 108 | C=0.694 | T=0.306 |
| Genome-wide autozygosity in Daghestan | South Asian | Sub | 98 | C=0.78 | T=0.22 |
| Genome-wide autozygosity in Daghestan | Caucasus | Sub | 36 | C=0.72 | T=0.28 |
| Genome of the Netherlands Release 5 | Genome of the Netherlands | Study-wide | 998 | C=0.673 | T=0.327 |
| PharmGKB Aggregated | Global | Study-wide | 946 | C=0.754 | T=0.246 |
| PharmGKB Aggregated | PA135135996 | Sub | 946 | C=0.754 | T=0.246 |
| CNV burdens in cranial meningiomas | Global | Study-wide | 784 | C=0.454 | T=0.546 |
| CNV burdens in cranial meningiomas | CRM | Sub | 784 | C=0.454 | T=0.546 |
| Northern Sweden | ACPOP | Study-wide | 600 | C=0.673 | T=0.327 |
| SGDP_PRJ | Global | Study-wide | 330 | C=0.367 | T=0.633 |
| Qatari | Global | Study-wide | 216 | C=0.667 | T=0.333 |
| A Vietnamese Genetic Variation Database | Global | Study-wide | 210 | C=0.524 | T=0.476 |
| The Danish reference pan genome | Danish | Study-wide | 40 | C=0.68 | T=0.33 |
| Siberian | Global | Study-wide | 38 | C=0.37 | T=0.63 |
Help
Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.
Genomic Placements
| Sequence name | Change |
|---|---|
| GRCh38.p14 chr 1 | NC_000001.11:g.159712443C>T |
| GRCh37.p13 chr 1 | NC_000001.10:g.159682233C>T |
| CRP RefSeqGene | NG_013007.1:g.7147G>A |
Gene: CRP, C-reactive protein
(minus strand)
| Molecule type | Change | Amino acid[Codon] | SO Term |
|---|---|---|---|
| CRP transcript variant 2 | NM_000567.3:c.*1082= | N/A | 3 Prime UTR Variant |
| CRP transcript variant 1 | NM_001329057.2:c.*374= | N/A | 3 Prime UTR Variant |
| CRP transcript variant 3 | NM_001329058.2:c.*148= | N/A | 3 Prime UTR Variant |
| CRP transcript variant 4 | NM_001382703.1:c.*1082= | N/A | 3 Prime UTR Variant |
Help
Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.
Allele: T (allele ID:
1685435
)
| ClinVar Accession | Disease Names | Clinical Significance |
|---|---|---|
| RCV002259422.1 | Inflammation | Uncertain-Significance |
Help
Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".
| Placement | C= | T |
|---|---|---|
| GRCh38.p14 chr 1 | NC_000001.11:g.159712443= | NC_000001.11:g.159712443C>T |
| GRCh37.p13 chr 1 | NC_000001.10:g.159682233= | NC_000001.10:g.159682233C>T |
| CRP RefSeqGene | NG_013007.1:g.7147= | NG_013007.1:g.7147G>A |
| CRP transcript variant 2 | NM_000567.3:c.*1082= | NM_000567.3:c.*1082G>A |
| CRP transcript variant 2 | NM_000567.2:c.*1082= | NM_000567.2:c.*1082G>A |
| CRP transcript variant 1 | NM_001329057.2:c.*374= | NM_001329057.2:c.*374G>A |
| CRP transcript variant 1 | NM_001329057.1:c.*374= | NM_001329057.1:c.*374G>A |
| CRP transcript variant 3 | NM_001329058.2:c.*148= | NM_001329058.2:c.*148G>A |
| CRP transcript variant 3 | NM_001329058.1:c.*148= | NM_001329058.1:c.*148G>A |
| CRP transcript variant 4 | NM_001382703.1:c.*1082= | NM_001382703.1:c.*1082G>A |
Help
Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.
131 SubSNP,
23 Frequency,
1 ClinVar
submissions
| No | Submitter | Submission ID | Date (Build) |
|---|---|---|---|
| 1 | WIAF | ss1230 | Sep 19, 2000 (36) |
| 2 | UWGC | ss7401 | Sep 19, 2000 (52) |
| 3 | CGAP-GAI | ss9603 | Sep 19, 2000 (52) |
| 4 | WIAF | ss19362 | Sep 19, 2000 (92) |
| 5 | LEE | ss1524257 | Oct 04, 2000 (86) |
| 6 | TSC-CSHL | ss3327485 | Sep 28, 2001 (100) |
| 7 | SC_JCM | ss3979041 | Sep 28, 2001 (100) |
| 8 | PGA-UW-FHCRC | ss4328242 | Mar 26, 2002 (103) |
| 9 | LEE | ss4415181 | May 29, 2002 (106) |
| 10 | WI_SSAHASNP | ss6408725 | Feb 20, 2003 (111) |
| 11 | SNP500CANCER | ss8819703 | Jul 02, 2003 (116) |
| 12 | JDRF_WT_DIL | ss28514825 | Sep 24, 2004 (126) |
| 13 | PHARMGKB_PARC | ss69366358 | May 16, 2007 (127) |
| 14 | ILLUMINA | ss75070507 | Dec 06, 2007 (129) |
| 15 | BCMHGSC_JDW | ss87836432 | Mar 23, 2008 (129) |
| 16 | BGI | ss102789100 | Dec 01, 2009 (131) |
| 17 | 1000GENOMES | ss108626774 | Jan 23, 2009 (130) |
| 18 | KRIBB_YJKIM | ss119336955 | Dec 01, 2009 (131) |
| 19 | ENSEMBL | ss138088980 | Dec 01, 2009 (131) |
| 20 | ILLUMINA | ss160029143 | Dec 01, 2009 (131) |
| 21 | COMPLETE_GENOMICS | ss165282618 | Jul 04, 2010 (132) |
| 22 | COMPLETE_GENOMICS | ss167175505 | Jul 04, 2010 (132) |
| 23 | ILLUMINA | ss171815708 | Jul 04, 2010 (132) |
| 24 | PAGE_STUDY | ss181835880 | Jul 04, 2010 (132) |
| 25 | BUSHMAN | ss199132493 | Jul 04, 2010 (132) |
| 26 | 1000GENOMES | ss210649613 | Jul 14, 2010 (132) |
| 27 | 1000GENOMES | ss218669513 | Jul 14, 2010 (132) |
| 28 | 1000GENOMES | ss230744882 | Jul 14, 2010 (132) |
| 29 | 1000GENOMES | ss238389977 | Jul 15, 2010 (132) |
| 30 | ILLUMINA | ss244275102 | Jul 04, 2010 (132) |
| 31 | GMI | ss276064584 | May 04, 2012 (137) |
| 32 | GMI | ss284159056 | Apr 25, 2013 (138) |
| 33 | PJP | ss290644245 | May 09, 2011 (134) |
| 34 | ILLUMINA | ss410897290 | Sep 17, 2011 (135) |
| 35 | ILLUMINA | ss479660654 | May 04, 2012 (137) |
| 36 | ILLUMINA | ss479666041 | May 04, 2012 (137) |
| 37 | ILLUMINA | ss480182369 | Sep 08, 2015 (146) |
| 38 | ILLUMINA | ss484628999 | May 04, 2012 (137) |
| 39 | ILLUMINA | ss536749990 | Sep 08, 2015 (146) |
| 40 | TISHKOFF | ss554748474 | Apr 25, 2013 (138) |
| 41 | SSMP | ss648437407 | Apr 25, 2013 (138) |
| 42 | ILLUMINA | ss778773152 | Sep 08, 2015 (146) |
| 43 | ILLUMINA | ss782761309 | Sep 08, 2015 (146) |
| 44 | ILLUMINA | ss783727731 | Sep 08, 2015 (146) |
| 45 | ILLUMINA | ss832013574 | Sep 08, 2015 (146) |
| 46 | ILLUMINA | ss834233023 | Sep 08, 2015 (146) |
| 47 | EVA-GONL | ss975719515 | Aug 21, 2014 (142) |
| 48 | JMKIDD_LAB | ss1068295890 | Aug 21, 2014 (142) |
| 49 | 1000GENOMES | ss1293068391 | Aug 21, 2014 (142) |
| 50 | HAMMER_LAB | ss1397260916 | Sep 08, 2015 (146) |
| 51 | DDI | ss1425989346 | Apr 01, 2015 (144) |
| 52 | EVA_GENOME_DK | ss1574415293 | Apr 01, 2015 (144) |
| 53 | EVA_DECODE | ss1585102566 | Apr 01, 2015 (144) |
| 54 | EVA_UK10K_ALSPAC | ss1601289120 | Apr 01, 2015 (144) |
| 55 | EVA_UK10K_TWINSUK | ss1644283153 | Apr 01, 2015 (144) |
| 56 | EVA_SVP | ss1712373704 | Apr 01, 2015 (144) |
| 57 | ILLUMINA | ss1751875512 | Sep 08, 2015 (146) |
| 58 | WEILL_CORNELL_DGM | ss1918955110 | Feb 12, 2016 (147) |
| 59 | ILLUMINA | ss1958323107 | Feb 12, 2016 (147) |
| 60 | GENOMED | ss1966875366 | Jul 19, 2016 (147) |
| 61 | JJLAB | ss2019991798 | Sep 14, 2016 (149) |
| 62 | ILLUMINA | ss2094784673 | Dec 20, 2016 (150) |
| 63 | ILLUMINA | ss2094978644 | Dec 20, 2016 (150) |
| 64 | USC_VALOUEV | ss2148018015 | Dec 20, 2016 (150) |
| 65 | HUMAN_LONGEVITY | ss2166829428 | Dec 20, 2016 (150) |
| 66 | SYSTEMSBIOZJU | ss2624504405 | Nov 08, 2017 (151) |
| 67 | ILLUMINA | ss2632580687 | Nov 08, 2017 (151) |
| 68 | ILLUMINA | ss2635003707 | Nov 08, 2017 (151) |
| 69 | GRF | ss2697991992 | Nov 08, 2017 (151) |
| 70 | ILLUMINA | ss2710683719 | Nov 08, 2017 (151) |
| 71 | GNOMAD | ss2761729161 | Nov 08, 2017 (151) |
| 72 | AFFY | ss2984881826 | Nov 08, 2017 (151) |
| 73 | AFFY | ss2985526429 | Nov 08, 2017 (151) |
| 74 | SWEGEN | ss2987810794 | Nov 08, 2017 (151) |
| 75 | ILLUMINA | ss3021141796 | Nov 08, 2017 (151) |
| 76 | BIOINF_KMB_FNS_UNIBA | ss3023753265 | Nov 08, 2017 (151) |
| 77 | CSHL | ss3343726418 | Nov 08, 2017 (151) |
| 78 | ILLUMINA | ss3626218096 | Oct 11, 2018 (152) |
| 79 | ILLUMINA | ss3630613271 | Oct 11, 2018 (152) |
| 80 | ILLUMINA | ss3632911339 | Oct 11, 2018 (152) |
| 81 | ILLUMINA | ss3633606759 | Oct 11, 2018 (152) |
| 82 | ILLUMINA | ss3634352941 | Oct 11, 2018 (152) |
| 83 | ILLUMINA | ss3635300176 | Oct 11, 2018 (152) |
| 84 | ILLUMINA | ss3636031636 | Oct 11, 2018 (152) |
| 85 | ILLUMINA | ss3637050672 | Oct 11, 2018 (152) |
| 86 | ILLUMINA | ss3637789839 | Oct 11, 2018 (152) |
| 87 | ILLUMINA | ss3640060295 | Oct 11, 2018 (152) |
| 88 | ILLUMINA | ss3642798908 | Oct 11, 2018 (152) |
| 89 | ILLUMINA | ss3651477048 | Oct 11, 2018 (152) |
| 90 | ILLUMINA | ss3651477049 | Oct 11, 2018 (152) |
| 91 | ILLUMINA | ss3653651146 | Oct 11, 2018 (152) |
| 92 | EGCUT_WGS | ss3655752274 | Jul 12, 2019 (153) |
| 93 | EVA_DECODE | ss3687852950 | Jul 12, 2019 (153) |
| 94 | ILLUMINA | ss3725070378 | Jul 12, 2019 (153) |
| 95 | ACPOP | ss3727515473 | Jul 12, 2019 (153) |
| 96 | ILLUMINA | ss3744653839 | Jul 12, 2019 (153) |
| 97 | EVA | ss3746850931 | Jul 12, 2019 (153) |
| 98 | PAGE_CC | ss3770845059 | Jul 12, 2019 (153) |
| 99 | ILLUMINA | ss3772154925 | Jul 12, 2019 (153) |
| 100 | PACBIO | ss3783576595 | Jul 12, 2019 (153) |
| 101 | PACBIO | ss3789206327 | Jul 12, 2019 (153) |
| 102 | PACBIO | ss3794078336 | Jul 12, 2019 (153) |
| 103 | KHV_HUMAN_GENOMES | ss3799851820 | Jul 12, 2019 (153) |
| 104 | EVA | ss3825578055 | Apr 25, 2020 (154) |
| 105 | EVA | ss3826443197 | Apr 25, 2020 (154) |
| 106 | EVA | ss3836616289 | Apr 25, 2020 (154) |
| 107 | EVA | ss3842025743 | Apr 25, 2020 (154) |
| 108 | SGDP_PRJ | ss3850078615 | Apr 25, 2020 (154) |
| 109 | KRGDB | ss3895299128 | Apr 25, 2020 (154) |
| 110 | EVA | ss3984465512 | Apr 25, 2021 (155) |
| 111 | EVA | ss3986013500 | Apr 25, 2021 (155) |
| 112 | EVA | ss4016940154 | Apr 25, 2021 (155) |
| 113 | TOPMED | ss4469585727 | Apr 25, 2021 (155) |
| 114 | TOMMO_GENOMICS | ss5146649020 | Apr 25, 2021 (155) |
| 115 | 1000G_HIGH_COVERAGE | ss5244416497 | Oct 12, 2022 (156) |
| 116 | EVA | ss5314653603 | Oct 12, 2022 (156) |
| 117 | EVA | ss5322276151 | Oct 12, 2022 (156) |
| 118 | HUGCELL_USP | ss5444993497 | Oct 12, 2022 (156) |
| 119 | EVA | ss5506042307 | Oct 12, 2022 (156) |
| 120 | 1000G_HIGH_COVERAGE | ss5517807123 | Oct 12, 2022 (156) |
| 121 | SANFORD_IMAGENETICS | ss5624219057 | Oct 12, 2022 (156) |
| 122 | SANFORD_IMAGENETICS | ss5626660656 | Oct 12, 2022 (156) |
| 123 | TOMMO_GENOMICS | ss5673896445 | Oct 12, 2022 (156) |
| 124 | EVA | ss5799499863 | Oct 12, 2022 (156) |
| 125 | YY_MCH | ss5801290007 | Oct 12, 2022 (156) |
| 126 | EVA | ss5832714188 | Oct 12, 2022 (156) |
| 127 | EVA | ss5847167493 | Oct 12, 2022 (156) |
| 128 | EVA | ss5849122126 | Oct 12, 2022 (156) |
| 129 | EVA | ss5910386169 | Oct 12, 2022 (156) |
| 130 | EVA | ss5938457452 | Oct 12, 2022 (156) |
| 131 | EVA | ss5979291615 | Oct 12, 2022 (156) |
| 132 | 1000Genomes | NC_000001.10 - 159682233 | Oct 11, 2018 (152) |
| 133 | 1000Genomes_30x | NC_000001.11 - 159712443 | Oct 12, 2022 (156) |
| 134 | The Avon Longitudinal Study of Parents and Children | NC_000001.10 - 159682233 | Oct 11, 2018 (152) |
| 135 | Genome-wide autozygosity in Daghestan | NC_000001.9 - 157948857 | Apr 25, 2020 (154) |
| 136 | Genetic variation in the Estonian population | NC_000001.10 - 159682233 | Oct 11, 2018 (152) |
| 137 | The Danish reference pan genome | NC_000001.10 - 159682233 | Apr 25, 2020 (154) |
| 138 | gnomAD - Genomes | NC_000001.11 - 159712443 | Apr 25, 2021 (155) |
| 139 | Genome of the Netherlands Release 5 | NC_000001.10 - 159682233 | Apr 25, 2020 (154) |
| 140 | HapMap | NC_000001.11 - 159712443 | Apr 25, 2020 (154) |
| 141 | KOREAN population from KRGDB | NC_000001.10 - 159682233 | Apr 25, 2020 (154) |
| 142 | Northern Sweden | NC_000001.10 - 159682233 | Jul 12, 2019 (153) |
| 143 | The PAGE Study | NC_000001.11 - 159712443 | Jul 12, 2019 (153) |
| 144 | CNV burdens in cranial meningiomas | NC_000001.10 - 159682233 | Apr 25, 2021 (155) |
| 145 | PharmGKB Aggregated | NC_000001.11 - 159712443 | Apr 25, 2020 (154) |
| 146 | Qatari | NC_000001.10 - 159682233 | Apr 25, 2020 (154) |
| 147 | SGDP_PRJ | NC_000001.10 - 159682233 | Apr 25, 2020 (154) |
| 148 | Siberian | NC_000001.10 - 159682233 | Apr 25, 2020 (154) |
| 149 | 8.3KJPN | NC_000001.10 - 159682233 | Apr 25, 2021 (155) |
| 150 | 14KJPN | NC_000001.11 - 159712443 | Oct 12, 2022 (156) |
| 151 | TopMed | NC_000001.11 - 159712443 | Apr 25, 2021 (155) |
| 152 | UK 10K study - Twins | NC_000001.10 - 159682233 | Oct 11, 2018 (152) |
| 153 | A Vietnamese Genetic Variation Database | NC_000001.10 - 159682233 | Jul 12, 2019 (153) |
| 154 | ALFA | NC_000001.11 - 159712443 | Apr 25, 2021 (155) |
| 155 | ClinVar | RCV002259422.1 | Oct 12, 2022 (156) |
Help
History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).
| Associated ID | History Updated (Build) |
|---|---|
| rs16955 | Jan 18, 2001 (92) |
| rs3190272 | Jul 03, 2002 (106) |
| rs17860476 | Mar 10, 2006 (126) |
Added to this RefSNP Cluster:
| Submission IDs | Observation SPDI | Canonical SPDI | Source RSIDs |
|---|---|---|---|
| 22166, ss87836432, ss108626774, ss165282618, ss167175505, ss199132493, ss210649613, ss276064584, ss284159056, ss290644245, ss479660654, ss1397260916, ss1585102566, ss1712373704, ss2635003707, ss3642798908 | NC_000001.9:157948856:C:T | NC_000001.11:159712442:C:T | (self) |
| 3865028, 2103509, 1490522, 1721983, 913660, 2476522, 800338, 14828, 997040, 2095595, 534369, 4618327, 2103509, 450758, ss218669513, ss230744882, ss238389977, ss479666041, ss480182369, ss484628999, ss536749990, ss554748474, ss648437407, ss778773152, ss782761309, ss783727731, ss832013574, ss834233023, ss975719515, ss1068295890, ss1293068391, ss1425989346, ss1574415293, ss1601289120, ss1644283153, ss1751875512, ss1918955110, ss1958323107, ss1966875366, ss2019991798, ss2094784673, ss2094978644, ss2148018015, ss2624504405, ss2632580687, ss2697991992, ss2710683719, ss2761729161, ss2984881826, ss2985526429, ss2987810794, ss3021141796, ss3343726418, ss3626218096, ss3630613271, ss3632911339, ss3633606759, ss3634352941, ss3635300176, ss3636031636, ss3637050672, ss3637789839, ss3640060295, ss3651477048, ss3651477049, ss3653651146, ss3655752274, ss3727515473, ss3744653839, ss3746850931, ss3772154925, ss3783576595, ss3789206327, ss3794078336, ss3825578055, ss3826443197, ss3836616289, ss3850078615, ss3895299128, ss3984465512, ss3986013500, ss4016940154, ss5146649020, ss5314653603, ss5322276151, ss5506042307, ss5624219057, ss5626660656, ss5799499863, ss5832714188, ss5847167493, ss5938457452, ss5979291615 | NC_000001.10:159682232:C:T | NC_000001.11:159712442:C:T | (self) |
| RCV002259422.1, 5333058, 28105258, 183630, 66528, 538, 7733549, 33192062, 13207792061, ss2166829428, ss3023753265, ss3687852950, ss3725070378, ss3770845059, ss3799851820, ss3842025743, ss4469585727, ss5244416497, ss5444993497, ss5517807123, ss5673896445, ss5801290007, ss5849122126, ss5910386169 | NC_000001.11:159712442:C:T | NC_000001.11:159712442:C:T | (self) |
| ss1230, ss7401, ss9603, ss19362, ss1524257, ss3327485, ss3979041, ss4328242, ss4415181, ss6408725, ss8819703, ss28514825, ss69366358, ss75070507, ss102789100, ss119336955, ss138088980, ss160029143, ss171815708, ss181835880, ss244275102, ss410897290 | NT_004487.19:11170874:C:T | NC_000001.11:159712442:C:T | (self) |
Help
Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.
173
citations for rs1205
| PMID | Title | Author | Year | Journal |
|---|---|---|---|---|
| 15897982 | Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. | Carlson CS et al. | 2005 | American journal of human genetics |
| 16519819 | Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. | Smyth DJ et al. | 2006 | BMC medical genetics |
| 16723442 | A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration. | Schaumberg DA et al. | 2006 | Investigative ophthalmology & visual science |
| 16733231 | Association study between C-reactive protein genes and ischemic stroke in Japanese subjects. | Morita A et al. | 2006 | American journal of hypertension |
| 16820586 | Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. | Podgoreanu MV et al. | 2006 | Circulation |
| 16832152 | Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese. | Morita A et al. | 2006 | Hypertension research |
| 17101857 | Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. | Crawford DC et al. | 2006 | Circulation |
| 17697822 | Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study). | Kardys I et al. | 2007 | The American journal of cardiology |
| 17888441 | Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study. | Hindorff LA et al. | 2008 | Atherosclerosis |
| 17900590 | C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study. | Zee RY et al. | 2008 | Atherosclerosis |
| 17903293 | Genome-wide association with select biomarker traits in the Framingham Heart Study. | Benjamin EJ et al. | 2007 | BMC medical genetics |
| 17956875 | DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study. | Kolz M et al. | 2008 | European heart journal |
| 18000615 | Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study. | Martínez-Calatrava MJ et al. | 2007 | Thrombosis and haemostasis |
| 18162041 | Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking. | Hughes AE et al. | 2007 | PLoS medicine |
| 18167554 | C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies. | Pai JK et al. | 2008 | PloS one |
| 18216863 | Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families. | Rhodes B et al. | 2008 | Genes and immunity |
| 18285551 | Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study. | Shen J et al. | 2008 | Diabetes care |
| 18385179 | Systemic inflammation, genetic susceptibility and lung function. | Sunyer J et al. | 2008 | The European respiratory journal |
| 18394581 | Bayesian meta-analysis of genetic association studies with different sets of markers. | Verzilli C et al. | 2008 | American journal of human genetics |
| 18439548 | Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. | Ridker PM et al. | 2008 | American journal of human genetics |
| 18500540 | Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach. | Rhodes B et al. | 2008 | Human genetics |
| 18700811 | Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. | Brunner EJ et al. | 2008 | PLoS medicine |
| 18704199 | Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration. | Kim IK et al. | 2008 | Molecular vision |
| 18714381 | Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study. | Kivimäki M et al. | 2008 | PloS one |
| 18714384 | The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. | Lawlor DA et al. | 2008 | PloS one |
| 18793001 | Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations. | Shih PB et al. | 2008 | The Journal of rheumatology |
| 19040303 | C-reactive protein gene polymorphisms in biopsy-proven giant cell arteritis from Northwestern Spain. | Palomino-Morales R et al. | 2009 | The Journal of rheumatology |
| 19074515 | Impact of genetic and environmental factors on hsCRP concentrations and response to therapeutic agents. | Shen J et al. | 2009 | Clinical chemistry |
| 19075099 | Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity. | Schumacher W et al. | 2009 | Hypertension (Dallas, Tex. |
| 19076828 | Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study. | Jylhävä J et al. | 2009 | Clinical and experimental immunology |
| 19095725 | Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort. | Lee CC et al. | 2009 | Clinical chemistry |
| 19101671 | Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity. | Teng MS et al. | 2009 | Atherosclerosis |
| 19139754 | The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study. | Eiriksdottir G et al. | 2009 | International journal of obesity (2005) |
| 19262552 | C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population. | Wang Q et al. | 2009 | Acta pharmacologica Sinica |
| 19267250 | C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older. | Pierce BL et al. | 2009 | Cancer causes & control |
| 19272152 | IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study. | Yanbaeva DG et al. | 2009 | BMC medical genetics |
| 19410251 | Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults. | Komurcu-Bayrak E et al. | 2009 | Atherosclerosis |
| 19426506 | C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery. | Perry TE et al. | 2009 | BMC medical genetics |
| 19433520 | Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study. | Almeida OP et al. | 2009 | International journal of epidemiology |
| 19436291 | C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk. | Eklund CM et al. | 2009 | British journal of cancer |
| 19567438 | Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. | Elliott P et al. | 2009 | JAMA |
| 19692124 | Complement factor H Y402H and C-reactive protein polymorphism and photodynamic therapy response in age-related macular degeneration. | Feng X et al. | 2009 | Ophthalmology |
| 19796676 | Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein. | Halder I et al. | 2010 | Brain, behavior, and immunity |
| 19821022 | Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples. | Marioni RE et al. | 2010 | Behavior genetics |
| 19906786 | Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. | Welsh P et al. | 2010 | The Journal of clinical endocrinology and metabolism |
| 19947988 | CRP gene variation and risk of community-acquired pneumonia. | Mukamal KJ et al. | 2010 | Respirology (Carlton, Vic.) |
| 19962488 | Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins. | Su S et al. | 2009 | The American journal of cardiology |
| 19965533 | CRP polymorphisms and progression of chronic kidney disease in African Americans. | Hung AM et al. | 2010 | Clinical journal of the American Society of Nephrology |
| 20078877 | Gene polymorphisms in association with emerging cardiovascular risk markers in adult women. | Fan AZ et al. | 2010 | BMC medical genetics |
| 20209660 | Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. | Burgess S et al. | 2010 | Statistics in medicine |
| 20333461 | Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population. | Ognjanovic S et al. | 2010 | Cancer causes & control |
| 20421535 | C-reactive protein and risk of lung cancer. | Chaturvedi AK et al. | 2010 | Journal of clinical oncology |
| 20538124 | Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs. | St Germaine CG et al. | 2010 | The American journal of cardiology |
| 20552244 | Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia. | Mölkänen T et al. | 2010 | European journal of clinical microbiology & infectious diseases |
| 20572894 | ||||
| 20616999 | Usefulness of Mendelian randomization in observational epidemiology. | Bochud M et al. | 2010 | International journal of environmental research and public health |
| 20733302 | Genetic variants in the C-reactive protein gene are associated with microangiopathic ischemic stroke. | Kuhlenbaeumer G et al. | 2010 | Cerebrovascular diseases (Basel, Switzerland) |
| 20856253 | Combined effect of C-reactive protein gene SNP +2147 A/G and interleukin-6 receptor gene SNP rs2229238 C/T on anthropometric characteristics among school children in Taiwan. | Lin FH et al. | 2011 | International journal of obesity (2005) |
| 20877716 | A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: implications for clinical interpretation. | Rhodes B et al. | 2010 | PLoS medicine |
| 20941391 | Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study. | Okser S et al. | 2010 | PLoS genetics |
| 20949557 | Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival. | Slattery ML et al. | 2011 | International journal of cancer |
| 20974458 | Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring. | Morales E et al. | 2011 | American journal of obstetrics and gynecology |
| 21034294 | C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects. | Veen G et al. | 2011 | Stress (Amsterdam, Netherlands) |
| 21054877 | Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994. | Ned RM et al. | 2010 | BMC medical genetics |
| 21080913 | The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study. | Bolton CE et al. | 2011 | Clinical science (London, England |
| 21094359 | Effect of central obesity, low high-density lipoprotein cholesterol and C-reactive protein polymorphisms on C-reactive protein levels during treatment with Rosuvastatin (10 mg Daily). | Hu M et al. | 2010 | The American journal of cardiology |
| 21116047 | Associations of gene sequence variation and serum levels of C-reactive protein and interleukin-6 with Alzheimer's disease and dementia. | Eriksson UK et al. | 2011 | Journal of Alzheimer's disease |
| 21149504 | Common variations in the genes encoding C-reactive protein, tumor necrosis factor-alpha, and interleukin-6, and the risk of clinical diabetes in the Women's Health Initiative Observational Study. | Chan KH et al. | 2011 | Clinical chemistry |
| 21246407 | C-reactive protein and glucose regulation in familial longevity. | Rozing MP et al. | 2011 | Age (Dordrecht, Netherlands) |
| 21293934 | Association of C-reactive protein gene polymorphisms and colorectal cancer. | Yang SH et al. | 2011 | Annals of surgical oncology |
| 21296145 | Association between adolescent emotional problems and metabolic syndrome: the modifying effect of C-reactive protein gene (CRP) polymorphisms. | Gaysina D et al. | 2011 | Brain, behavior, and immunity |
| 21325005 | Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. | Wensley F et al. | 2011 | BMJ (Clinical research ed.) |
| 21413847 | Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey. | Kettunen T et al. | 2011 | Scandinavian journal of clinical and laboratory investigation |
| 21569369 | CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey. | Hung AM et al. | 2011 | BMC medical genetics |
| 21575917 | C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants. | Ottaviani S et al. | 2011 | Translational research |
| 21647738 | Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment. | Wu Y et al. | 2012 | Inflammation |
| 21756351 | Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes. | Arora P et al. | 2011 | BMC medical genetics |
| 21790705 | The polymorphisms of C-reactive protein gene modify the association between central obesity and lung function in taiwan asthmatics. | Wang TN et al. | 2011 | Scandinavian journal of immunology |
| 21831326 | CRP gene variation affects early development of Alzheimer's disease-related plaques. | Kok EH et al. | 2011 | Journal of neuroinflammation |
| 21845926 | Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load. | Vasunilashorn S et al. | 2011 | Biodemography and social biology |
| 21915265 | C-reactive protein and genetic variants and cognitive decline in old age: the PROSPER study. | Mooijaart SP et al. | 2011 | PloS one |
| 21931794 | Common variants in CRP and LEPR influence high sensitivity C-reactive protein levels in North Indians. | Mahajan A et al. | 2011 | PloS one |
| 21937998 | Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults. | Curocichin G et al. | 2011 | Journal of human genetics |
| 21979869 | C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects. | Rius-Ottenheim N et al. | 2012 | Inflammation research |
| 22004660 | Genetic variants, immune function, and risk of pre-eclampsia among American Indians. | Best LG et al. | 2012 | American journal of reproductive immunology (New York, N.Y. |
| 22056417 | Association study of candidate gene polymorphisms and obesity in a young Mexican-American population from South Texas. | Duran-Gonzalez J et al. | 2011 | Archives of medical research |
| 22291609 | A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. | Naitza S et al. | 2012 | PLoS genetics |
| 22340269 | Translational studies of lipoprotein-associated phospholipase A₂ in inflammation and atherosclerosis. | Ferguson JF et al. | 2012 | Journal of the American College of Cardiology |
| 22492993 | C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. | Doumatey AP et al. | 2012 | Human molecular genetics |
| 22919647 | Host- and microbe determinants that may influence the success of S. aureus colonization. | Johannessen M et al. | 2012 | Frontiers in cellular and infection microbiology |
| 23039402 | Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. | Plant D et al. | 2012 | Arthritis research & therapy |
| 23049543 | Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico. | Martínez-Calleja A et al. | 2012 | Experimental diabetes research |
| 23212764 | Evaluation of the risk of lymph node metastasis using CRP 1846C>T genetic polymorphism in submucosal thoracic esophageal squamous cell carcinoma. | Motoyama S et al. | 2013 | Annals of surgical oncology |
| 23254959 | Serum C-reactive protein and risk of lung cancer: a case-control study. | Xu M et al. | 2013 | Medical oncology (Northwood, London, England) |
| 23267696 | Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study. | Guo Y et al. | 2012 | BMC medical genomics |
| 23397258 | Association study of CRP gene in systemic sclerosis in European Caucasian population. | Wipff J et al. | 2014 | Rheumatology international |
| 24574329 | Association of serum C-reactive protein levels with lupus disease activity in the absence of measurable interferon-α and a C-reactive protein gene variant. | Enocsson H et al. | 2014 | Arthritis & rheumatology (Hoboken, N.J.) |
| 24602049 | Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves. | An SH et al. | 2014 | Journal of clinical pharmacy and therapeutics |
| 24633920 | Evaluation of the potential for lymph node metastasis using CRP 1846C>T genetic polymorphism in invasive breast cancer. | Terata K et al. | 2014 | Tumour biology |
| 24763700 | New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis. | Vinayagamoorthy N et al. | 2014 | PloS one |
| 24862635 | Association of CRP gene polymorphisms with serum CRP level and handgrip strength in community-dwelling elders in Taiwan: Taichung Community Health Study for Elders (TCHS-E). | Lin CC et al. | 2014 | Experimental gerontology |
| 24894103 | Serum C-reactive protein level but not its gene polymorphism is associated with Takayasu arteritis. | Cheng Y et al. | 2016 | Clinical rheumatology |
| 25020710 | ||||
| 25025473 | Mutations of C-reactive protein (CRP) -286 SNP, APC and p53 in colorectal cancer: implication for a CRP-Wnt crosstalk. | Su HX et al. | 2014 | PloS one |
| 25043606 | Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk. | Nimptsch K et al. | 2015 | International journal of cancer |
| 25133031 | Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature. | Sarlos P et al. | 2014 | World journal of gastrointestinal pathophysiology |
| 25224558 | Association of variants in genes related to the immune response and obesity with BPH in CLUE II. | Lopez DS et al. | 2014 | Prostate cancer and prostatic diseases |
| 25314633 | Association between CRP gene polymorphisms and the risk of preeclampsia in Han Chinese women. | Wang Y et al. | 2014 | Genetic testing and molecular biomarkers |
| 25383745 | HIV-infection, atherosclerosis and the inflammatory pathway: candidate gene study in a Spanish HIV-infected population. | Ibáñez L et al. | 2014 | PloS one |
| 25603415 | C-reactive protein gene variants: independent association with late-life depression and circulating protein levels. | Ancelin ML et al. | 2015 | Translational psychiatry |
| 25636121 | Serum C-reactive protein and CRP genotype in pediatric inflammatory bowel disease: influence on phenotype, natural history, and response to therapy. | Henderson P et al. | 2015 | Inflammatory bowel diseases |
| 25993353 | Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents. | Todendi PF et al. | 2015 | Anais da Academia Brasileira de Ciencias |
| 26248682 | Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of Ageing. | Mekli K et al. | 2016 | Aging clinical and experimental research |
| 26330749 | Association of gene polymorphism with serum levels of inflammatory and angiogenic factors in Pakistani patients with age-related macular degeneration. | Ambreen F et al. | 2015 | Molecular vision |
| 26355258 | An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes. | Muiño E et al. | 2015 | Mediators of inflammation |
| 26379965 | Associations of immunity-related single nucleotide polymorphisms with overall survival among prostate cancer patients. | Miles FL et al. | 2015 | International journal of clinical and experimental medicine |
| 26446360 | Mendelian randomization studies of biomarkers and type 2 diabetes. | Abbasi A et al. | 2015 | Endocrine connections |
| 26451011 | Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas. | Montazeri Z et al. | 2016 | International journal of epidemiology |
| 26456189 | Interaction of SNP in the CRP gene and plasma fatty acid profile in inflammatory pattern: A cross-sectional population-based study. | Oki E et al. | 2016 | Nutrition (Burbank, Los Angeles County, Calif.) |
| 26473826 | Association of the C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism with Aortic Valve Calcification in Patients with Aortic Stenosis. | Wypasek E et al. | 2015 | International journal of molecular sciences |
| 26751459 | Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study. | Hernández-Díaz Y et al. | 2016 | International journal of environmental research and public health |
| 26799163 | Pretreatment serum interleukin-1β, interleukin-6, and tumor necrosis factor-α levels predict the progression of colorectal cancer. | Chang PH et al. | 2016 | Cancer medicine |
| 26999109 | Expression and Sequence Variants of Inflammatory Genes; Effects on Plasma Inflammation Biomarkers Following a 6-Week Supplementation with Fish Oil. | Cormier H et al. | 2016 | International journal of molecular sciences |
| 27016573 | Association of CRP gene polymorphisms with CRP levels, frailty and co-morbidity in an elderly Chinese population: results from RuLAS. | Liu ZY et al. | 2016 | Age and ageing |
| 27099791 | Combinations of Polymorphic Markers of Chemokine Genes, Their Receptors and Acute Phase Protein Genes As Potential Predictors of Coronary Heart Diseases. | Nasibullin TR et al. | 2016 | Acta naturae |
| 27266621 | Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis. | González-Giraldo Y et al. | 2016 | Journal of stroke and cerebrovascular diseases |
| 27274104 | A genetic-based algorithm for personalized resistance training. | Jones N et al. | 2016 | Biology of sport |
| 27313400 | CRP and SAA1 Haplotypes Are Associated with Both C-Reactive Protein and Serum Amyloid A Levels: Role of Suppression Effects. | Ko YL et al. | 2016 | Mediators of inflammation |
| 27342221 | Selecting instruments for Mendelian randomization in the wake of genome-wide association studies. | Swerdlow DI et al. | 2016 | International journal of epidemiology |
| 27344265 | Association of novel metrics of particulate matter with vascular markers of inflammation and coagulation in susceptible populations -results from a panel study. | Rückerl R et al. | 2016 | Environmental research |
| 27386381 | Association of inflammatory gene polymorphisms with mechanical heart valve reoperation. | Lee KE et al. | 2016 | SpringerPlus |
| 27417569 | Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases. | Bek S et al. | 2016 | Alimentary pharmacology & therapeutics |
| 27534721 | Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis. | López-Mejías R et al. | 2016 | Scientific reports |
| 27555379 | Genetic Contributions of Inflammation to Depression. | Barnes J et al. | 2017 | Neuropsychopharmacology |
| 27589735 | A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification. | Ponasenko AV et al. | 2016 | International journal of molecular sciences |
| 27643980 | Low-grade inflammation markers in children and adolescents: Influence of anthropometric characteristics and CRP and IL6 polymorphisms. | Todendi PF et al. | 2016 | Cytokine |
| 27705004 | CRP/IL-6/IL-10 Single-Nucleotide Polymorphisms Correlate with the Susceptibility and Severity of Community-Acquired Pneumonia. | Chou SC et al. | 2016 | Genetic testing and molecular biomarkers |
| 28277782 | Relationship Between C-Reactive Protein Serum Concentration and the 1846 C>T (rs1205) Polymorphism in Patients with Acute Coronary Syndrome from Western Mexico. | Reynoso-Villalpando GL et al. | 2017 | Genetic testing and molecular biomarkers |
| 28287042 | Impact of CRP gene and additional gene-smoking interaction on ischemic stroke in a Chinese Han population. | Wu Z et al. | 2017 | Neurological research |
| 28350535 | Relationship between polymorphisms in the CRP, LEP and LEPR genes and high sensitivity C-reactive protein levels in Spanish children. | Navarro P et al. | 2017 | Clinical chemistry and laboratory medicine |
| 28549956 | Serum High-Sensitive C-Reactive Protein Level and CRP Genetic Polymorphisms Are Associated with Abdominal Aortic Aneurysm. | Shangwei Z et al. | 2017 | Annals of vascular surgery |
| 28620227 | Gene-physical activity interactions in lower extremity performance: inflammatory genes CRP, TNF-α, and LTA in community-dwelling elders. | Liu CS et al. | 2017 | Scientific reports |
| 28659664 | Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis. | Ponasenko AV et al. | 2017 | Mediators of inflammation |
| 28706007 | C-reactive protein gene rs1205 polymorphism is not associated with the risk of colorectal cancer. | Fang D et al. | 2017 | Bioscience reports |
| 28750115 | Association of C-Reactive Protein Genetic Polymorphisms With Late Age-Related Macular Degeneration. | Cipriani V et al. | 2017 | JAMA ophthalmology |
| 28801571 | CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study. | Sheu WH et al. | 2017 | Scientific reports |
| 28867284 | CRP polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, PTSD, and C-reactive protein. | Miller MW et al. | 2018 | Brain, behavior, and immunity |
| 29024426 | C-reactive protein gene polymorphisms (rs1205) in Asian Indian patients with Takayasu arteritis: Associations and phenotype correlations. | Nair AM et al. | 2018 | International journal of rheumatic diseases |
| 29340226 | Depression is Associated with CRP SNPs in Patients with Family History. | Yibulaiyin H et al. | 2017 | Translational neuroscience |
| 29352395 | Association between CRP genetic diversity and bipolar disorder comorbid complications. | Boukouaci W et al. | 2018 | International journal of bipolar disorders |
| 29379005 | Association of Single-Nucleotide Polymorphisms of C-Reactive Protein Gene with Susceptibility to Infantile Sepsis in Southern China. | Liu C et al. | 2018 | Medical science monitor |
| 29556849 | C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population. | Atisha-Fregoso Y et al. | 2018 | Clinical rheumatology |
| 29802748 | Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk. | Huang BZ et al. | 2018 | Molecular carcinogenesis |
| 30048584 | Higher Serum C Reactive Protein Determined C Reactive Protein Single-Nucleotide Polymorphisms Are Involved in Inherited Depression. | Wang S et al. | 2018 | Psychiatry investigation |
| 30485313 | The magnitude of Yo-Yo test improvements following an aerobic training intervention are associated with total genotype score. | Pickering C et al. | 2018 | PloS one |
| 31500937 | Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents. | Arouca AB et al. | 2020 | Clinical nutrition (Edinburgh, Scotland) |
| 31637880 | MicroRNA-binding site polymorphisms and risk of colorectal cancer: A systematic review and meta-analysis. | Gholami M et al. | 2019 | Cancer medicine |
| 31692152 | Association of plasma C-reactive protein with ischaemic stroke: a Mendelian randomization study. | Zhang X et al. | 2020 | European journal of neurology |
| 31694563 | Association of high sensitive C-reactive protein with coronary heart disease: a Mendelian randomization study. | Zhuang Q et al. | 2019 | BMC medical genetics |
| 31788733 | C-reactive protein concentration in bipolar disorder: association with genetic variants. | Evers AK et al. | 2019 | International journal of bipolar disorders |
| 31818908 | Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer. | Montazeri Z et al. | 2020 | Gut |
| 31959465 | Association of high-sensitivity C-reactive protein with susceptibility to Schizophrenia in Tunisian population. | Ayari F et al. | 2020 | L'Encephale |
| 32329054 | Association of C-reactive protein (CRP) rs1205 and rs2808630 variants and risk of cancer. | Pan HY et al. | 2020 | Journal of cellular physiology |
| 32477370 | A Functional Genetic Variant at the C-Reactive Protein Promoter (rs3091244) Is Not Associated With Cancer Risk in a Chinese Population. | Wang MY et al. | 2020 | Frontiers in immunology |
| 32514365 | C-reactive protein gene rs1205 polymorphism is associated with low-grade chronic inflammation in postmenopausal women. | de Santis IP et al. | 2020 | Women's midlife health |
| 32769481 | Inflammatory Genotype Moderates the Association Between Anxiety and Systemic Inflammation in Adults at Risk for Cardiovascular Disease. | Key KV et al. | 2022 | The Journal of cardiovascular nursing |
| 33296257 | The Genetic Variants -717T>C (rs2794521), 1444G>A (rs1130864), and 1846 C > T (rs1205) of CRP Gene, Their Haplotypes, and Their Association with Serum CRP Levels, Acute Coronary Syndrome, and Diabetes in Patients from Western Mexico. | Reynoso-Villalpando GL et al. | 2021 | Metabolic syndrome and related disorders |
| 33584722 | C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205. | Enocsson H et al. | 2020 | Frontiers in immunology |
| 33707594 | Unactivated leukocyte expression of C-reactive protein is minimal and not dependent on rs1205 genotype. | Best LG et al. | 2021 | Scientific reports |
| 34308116 | Genetic factors associated with obesity risks in a Kazakhstani population. | Razbekova M et al. | 2021 | BMJ nutrition, prevention & health |
| 34834553 | Innate-Immunity Genes in Obesity. | Mikhailova SV et al. | 2021 | Journal of personalized medicine |
| 35062811 | Association of CRP Haplotypes in Rheumatoid Arthritis and their Correlation with Severity of the Disease. | Kapur S et al. | 2022 | The Journal of the Association of Physicians of India |
| 35428187 | CRP levels are significantly associated with CRP genotype and estrogen use in The Lifestyle, Biomarker and Atherosclerosis (LBA) study. | Fransén K et al. | 2022 | BMC cardiovascular disorders |
Help
The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.
Genome context:
Select flank length:
Genomic regions, transcripts, and products
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Help
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.