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Vulvar carcinoma

MedGen UID:
146159
Concept ID:
C0677055
Neoplastic Process
Synonyms: Cancer of the Vulva; Cancer of Vulva; carcinoma of mammalian vulva; Carcinoma of the Vulva; carcinoma of the vulva; Carcinoma of Vulva; Carcinoma of vulva; carcinoma of vulva; mammalian vulva carcinoma; Vulva Cancer; Vulva Carcinoma; vulva carcinoma; Vulvar Cancer; Vulvar Carcinoma; vulvar carcinoma
 
Monarch Initiative: MONDO:0005215
Orphanet: ORPHA494418

Definition

A group of rare tumors of the vulva comprising HPV-associated and HPV-independent squamous cell carcinomas as the most frequent malignant vulvar tumors, basal cell carcinomas, adenocarcinomas, and Bartholin gland carcinomas. Depending on the type of tumor and disease stage, patients may present with a painless vulvar mass or ulcer, or with pruritus, a burning sensation, pain, or bleeding. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar carcinoma

Professional guidelines

PubMed

Chiva L, Gonzalez-Rodriguez M, Tendobi C
Int J Gynecol Cancer 2022 Nov 7;32(11):1492. doi: 10.1136/ijgc-2022-003917. PMID: 36343970
Luque-Luna M, Bosch-Amate X, Morgado-Carrasco D
Actas Dermosifiliogr 2022 Jul-Aug;113(7):722-723. Epub 2022 Mar 8 doi: 10.1016/j.ad.2020.12.008. PMID: 35461636
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

Recent clinical studies

Etiology

Cao D, Zhang S, Zhang Y, Shao M, Yang Q, Wang P
BMC Cancer 2024 Aug 21;24(1):1032. doi: 10.1186/s12885-024-12787-5. PMID: 39169299Free PMC Article
Hami LT, Lampe B, Mallmann P, Forner DM
Oncol Res Treat 2018;41(9):520-524. Epub 2018 Jul 24 doi: 10.1159/000488800. PMID: 30041246
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Moore DH, Ali S, Koh WJ, Michael H, Barnes MN, McCourt CK, Homesley HD, Walker JL
Gynecol Oncol 2012 Mar;124(3):529-33. Epub 2011 Nov 9 doi: 10.1016/j.ygyno.2011.11.003. PMID: 22079361
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Diagnosis

Chargari C, Wasserman J, Gabro A, Canlobre G, Spano JP, Uzan C, Maingon P
J Clin Oncol 2024 Mar 10;42(8):961-972. Epub 2024 Feb 5 doi: 10.1200/JCO.23.01187. PMID: 38315939
Chiva L, Gonzalez-Rodriguez M, Tendobi C
Int J Gynecol Cancer 2022 Nov 7;32(11):1492. doi: 10.1136/ijgc-2022-003917. PMID: 36343970
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article
Schwartz PE
Menopause 2011 Oct;18(10):1042-3. doi: 10.1097/gme.0b013e31822a8966. PMID: 22046600
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Therapy

Cao D, Zhang S, Zhang Y, Shao M, Yang Q, Wang P
BMC Cancer 2024 Aug 21;24(1):1032. doi: 10.1186/s12885-024-12787-5. PMID: 39169299Free PMC Article
Naumann RW, Hollebecque A, Meyer T, Devlin MJ, Oaknin A, Kerger J, López-Picazo JM, Machiels JP, Delord JP, Evans TRJ, Boni V, Calvo E, Topalian SL, Chen T, Soumaoro I, Li B, Gu J, Zwirtes R, Moore KN
J Clin Oncol 2019 Nov 1;37(31):2825-2834. Epub 2019 Sep 5 doi: 10.1200/JCO.19.00739. PMID: 31487218Free PMC Article
Moore DH, Ali S, Koh WJ, Michael H, Barnes MN, McCourt CK, Homesley HD, Walker JL
Gynecol Oncol 2012 Mar;124(3):529-33. Epub 2011 Nov 9 doi: 10.1016/j.ygyno.2011.11.003. PMID: 22079361
Coleman RL, Santoso JT
Curr Treat Options Oncol 2000 Jun;1(2):177-90. doi: 10.1007/s11864-000-0063-4. PMID: 12057056
Comas MR, Morris CH, Averette HE
Obstet Gynecol 1969 Feb;33(2):177-81. PMID: 5775177

Prognosis

Chargari C, Wasserman J, Gabro A, Canlobre G, Spano JP, Uzan C, Maingon P
J Clin Oncol 2024 Mar 10;42(8):961-972. Epub 2024 Feb 5 doi: 10.1200/JCO.23.01187. PMID: 38315939
van der Linden M, Meeuwis KA, Bulten J, Bosse T, van Poelgeest MI, de Hullu JA
Crit Rev Oncol Hematol 2016 May;101:60-74. Epub 2016 Mar 4 doi: 10.1016/j.critrevonc.2016.03.008. PMID: 26971063
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775
Snijders-Keilholz T, Trimbos JB, Hermans J, Leer JW
Acta Obstet Gynecol Scand 1993 Nov;72(8):668-73. doi: 10.3109/00016349309021162. PMID: 7505077

Clinical prediction guides

Zięba S, Chechlińska M, Kowalik A, Kowalewska M
Gynecol Oncol 2020 Aug;158(2):498-506. Epub 2020 Jun 7 doi: 10.1016/j.ygyno.2020.05.034. PMID: 32522421
Naumann RW, Hollebecque A, Meyer T, Devlin MJ, Oaknin A, Kerger J, López-Picazo JM, Machiels JP, Delord JP, Evans TRJ, Boni V, Calvo E, Topalian SL, Chen T, Soumaoro I, Li B, Gu J, Zwirtes R, Moore KN
J Clin Oncol 2019 Nov 1;37(31):2825-2834. Epub 2019 Sep 5 doi: 10.1200/JCO.19.00739. PMID: 31487218Free PMC Article
Di Mauro D, D'Hoore A, Penninckx F, De Wever I, Vergote I, Hierner R
Colorectal Dis 2009 Jun;11(5):508-12. Epub 2008 Jul 15 doi: 10.1111/j.1463-1318.2008.01641.x. PMID: 18637929
Grendys EC Jr, Salud C, Durfee JK, Fiorica JV
Surg Oncol Clin N Am 1999 Jul;8(3):541-53, x. PMID: 10448696
Kaufman RH, Dreesman GR, Burek J, Korhonen MO, Matson DO, Melnick JL, Powell KL, Purifoy DJ, Courtney RJ, Adam E
N Engl J Med 1981 Aug 27;305(9):483-8. doi: 10.1056/NEJM198108273050903. PMID: 6265780

Recent systematic reviews

Turetta C, Mazzeo R, Capalbo G, Miano S, Fruscio R, Di Donato V, Falcone F, Mangili G, Pignata S, Palaia I
Tumori 2024 Apr;110(2):96-108. Epub 2023 Nov 13 doi: 10.1177/03008916231208308. PMID: 37953636
Lancellotta V, Macchia G, Garganese G, Fionda B, Fragomeni SM, D'Aviero A, Casà C, Gui B, Gentileschi S, Corrado G, Inzani F, Rovirosa A, Morganti AG, Gambacorta MA, Tagliaferri L
Clin Transl Oncol 2021 Aug;23(8):1611-1619. Epub 2021 Mar 1 doi: 10.1007/s12094-021-02557-1. PMID: 33650029
Te Grootenhuis NC, Pouwer AW, de Bock GH, Hollema H, Bulten J, van der Zee AGJ, de Hullu JA, Oonk MHM
Gynecol Oncol 2018 Mar;148(3):622-631. Epub 2017 Nov 12 doi: 10.1016/j.ygyno.2017.11.006. PMID: 29137809
Sznurkowski JJ
Eur J Cancer Care (Engl) 2016 Jul;25(4):638-46. Epub 2016 Feb 16 doi: 10.1111/ecc.12455. PMID: 26880231
van Seters M, van Beurden M, de Craen AJ
Gynecol Oncol 2005 May;97(2):645-51. doi: 10.1016/j.ygyno.2005.02.012. PMID: 15863172

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

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