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| Status |
Public on Jun 30, 2007 |
| Title |
SNP array analysis of neuroblastoma tumors |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
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| Summary |
Chromosome 1p LOH was seen in one-third of cases. LOH events on chromosomes 11q and 1p were generally accompanied by copy number loss. The one exception was on chromosome 11p, where LOH in all 4 cases was accompanied by normal copy number or diploidy, implying uniparental disomy. Amplification of MYCN was also noted, and also, amplification of a second gene, ALK, in a single case.
Keywords: SNP array analysis
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| Overall design |
We analyzed paired blood and primary tumor samples from 22 children with high-risk neuroblastoma for loss of heterozygosity (LOH) and DNA copy number change.
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| Contributor(s) |
George R, Attiyeh E |
| Citation(s) |
17327916, 18923525 |
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| Submission date |
Jun 29, 2007 |
| Last update date |
Feb 18, 2014 |
| Contact name |
Rani E. George |
| E-mail(s) |
[email protected]
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| Phone |
6176325281
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| Organization name |
Dana-Farber Cancer Institute
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| Department |
Pediatric Oncology
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| Lab |
A. Thomas Look
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| Street address |
Dana 322, 44 Binney St
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (2) |
| GPL1266 |
[Mapping10K_Xba131] Affymetrix Human Mapping 10K SNP Array |
| GPL2641 |
[Mapping10K_Xba142] Affymetrix Human Mapping 10K 2.0 Array |
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| Samples (44)
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| Relations |
| BioProject |
PRJNA101329 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE8333_CopyNumber_1.txt |
2.7 Mb |
(ftp)(http) |
TXT |
| GSE8333_CopyNumber_2.txt |
1.8 Mb |
(ftp)(http) |
TXT |
| GSE8333_RAW.tar |
152.4 Mb |
(http)(custom) |
TAR (of CEL, TXT) |
| GSE8333_Sample_file.txt |
923 b |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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