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Neuroendocrine carcinoma

MedGen UID:
104919
•Concept ID:
C0206695
•
Neoplastic Process
Synonyms: Carcinoma, Neuroendocrine; Carcinomas, Neuroendocrine; Neuroendocrine Carcinoma; Neuroendocrine Carcinomas
SNOMED CT: Neuroendocrine carcinoma (253000007); Neuroendocrine carcinoma (1286767006)
 
Monarch Initiative: MONDO:0002120

Definition

A usually aggressive carcinoma composed of malignant cells exhibiting neuroendocrine differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroendocrine carcinoma

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Merkel cell carcinoma: An updated review of pathogenesis, diagnosis, and treatment options.
Hernandez LE, Mohsin N, Yaghi M, Frech FS, Dreyfuss I, Nouri K
Dermatol Ther 2022 Mar;35(3):e15292. Epub 2022 Jan 5 doi: 10.1111/dth.15292. PMID: 34967084
Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms.
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma.
Sorbye H, Grande E, Pavel M, Tesselaar M, Fazio N, Reed NS, Knigge U, Christ E, Ambrosini V, Couvelard A, Tiensuu Janson E
J Neuroendocrinol 2023 Mar;35(3):e13249. Epub 2023 Mar 16 doi: 10.1111/jne.13249. PMID: 36924180
Small Cell (Neuroendocrine) Carcinoma of the Cervix: An Analysis for 19 Cases and Literature Review.
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas.
Oronsky B, Ma PC, Morgensztern D, Carter CA
Neoplasia 2017 Dec;19(12):991-1002. Epub 2017 Nov 5 doi: 10.1016/j.neo.2017.09.002. PMID: 29091800Free PMC Article

Diagnosis

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma.
Sorbye H, Grande E, Pavel M, Tesselaar M, Fazio N, Reed NS, Knigge U, Christ E, Ambrosini V, Couvelard A, Tiensuu Janson E
J Neuroendocrinol 2023 Mar;35(3):e13249. Epub 2023 Mar 16 doi: 10.1111/jne.13249. PMID: 36924180
Neuroendocrine Carcinoma of the Gallbladder.
Sharma A, Saluja SS, Nag HH, Sharma M, Sakhuja P
Am Surg 2022 Nov;88(11):2768-2770. Epub 2020 Sep 16 doi: 10.1177/0003134820951466. PMID: 32935998
Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms.
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Lung Cancer Pathology: Current Concepts.
Travis WD
Clin Chest Med 2020 Mar;41(1):67-85. Epub 2020 Jan 2 doi: 10.1016/j.ccm.2019.11.001. PMID: 32008630
Large cell/neuroendocrine carcinoma.
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008

Therapy

Advancing immunotherapy in small cell lung cancer.
Carlisle JW, Leal T
Cancer 2023 Nov 15;129(22):3525-3534. Epub 2023 Aug 21 doi: 10.1002/cncr.34977. PMID: 37602492
European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma.
Sorbye H, Grande E, Pavel M, Tesselaar M, Fazio N, Reed NS, Knigge U, Christ E, Ambrosini V, Couvelard A, Tiensuu Janson E
J Neuroendocrinol 2023 Mar;35(3):e13249. Epub 2023 Mar 16 doi: 10.1111/jne.13249. PMID: 36924180
Pralsetinib: First Approval.
Markham A
Drugs 2020 Nov;80(17):1865-1870. doi: 10.1007/s40265-020-01427-4. PMID: 33136236
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Large cell/neuroendocrine carcinoma.
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008

Prognosis

An update on the diagnosis of gastroenteropancreatic neuroendocrine neoplasms.
Fang JM, Li J, Shi J
World J Gastroenterol 2022 Mar 14;28(10):1009-1023. doi: 10.3748/wjg.v28.i10.1009. PMID: 35431496Free PMC Article
Epidemiology, Incidence, and Prevalence of Neuroendocrine Neoplasms: Are There Global Differences?
Das S, Dasari A
Curr Oncol Rep 2021 Mar 14;23(4):43. doi: 10.1007/s11912-021-01029-7. PMID: 33719003Free PMC Article
Sinonasal Undifferentiated Carcinoma.
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835
Immunohistochemistry, carcinomas of unknown primary, and incidence rates.
Stelow EB, Yaziji H
Semin Diagn Pathol 2018 Mar;35(2):143-152. Epub 2017 Nov 23 doi: 10.1053/j.semdp.2017.11.012. PMID: 29224972
Merkel cell carcinoma.
Becker JC
Ann Oncol 2010 Oct;21 Suppl 7:vii81-5. doi: 10.1093/annonc/mdq366. PMID: 20943647

Clinical prediction guides

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma.
Sorbye H, Grande E, Pavel M, Tesselaar M, Fazio N, Reed NS, Knigge U, Christ E, Ambrosini V, Couvelard A, Tiensuu Janson E
J Neuroendocrinol 2023 Mar;35(3):e13249. Epub 2023 Mar 16 doi: 10.1111/jne.13249. PMID: 36924180
Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.
Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Neuroendocrine neoplasms of the lung: Concepts and terminology.
Wick MR, Marchevsky AM
Semin Diagn Pathol 2015 Nov;32(6):445-55. Epub 2015 Sep 25 doi: 10.1053/j.semdp.2015.09.012. PMID: 26500079
Medullary Thyroid Carcinoma: Imaging.
Delorme S, Raue F
Recent Results Cancer Res 2015;204:91-116. doi: 10.1007/978-3-319-22542-5_4. PMID: 26494385

Recent systematic reviews

Management Strategies and Outcomes for Small Intestinal Neuroendocrine Tumours with Involvement of the Superior Mesenteric Vessels: A Systematic Review.
Kmiotek E, Lakda S, Borakati A, Ogunbiyi O, Mandair D, Caplin M, Toumpanakis C, Mirnezami R
Curr Oncol 2023 Oct 18;30(10):9192-9204. doi: 10.3390/curroncol30100664. PMID: 37887564Free PMC Article
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
A systematic review on sinonasal mixed adenoneuroendocrine carcinoma.
Issa K, Smith BD, Kaplan SJ, Madden J, Jang DW, Zomorodi A, Brizel D, Abi Hachem R
Int Forum Allergy Rhinol 2021 Sep;11(9):1391-1394. Epub 2021 May 19 doi: 10.1002/alr.22811. PMID: 34013656
Commonwealth Neuroendocrine Tumour Research Collaboration and the North American Neuroendocrine Tumor Society Guidelines for the Diagnosis and Management of Patients With Lung Neuroendocrine Tumors: An International Collaborative Endorsement and Update of the 2015 European Neuroendocrine Tumor Society Expert Consensus Guidelines.
Singh S, Bergsland EK, Card CM, Hope TA, Kunz PL, Laidley DT, Lawrence B, Leyden S, Metz DC, Michael M, Modahl LE, Myrehaug S, Padda SK, Pommier RF, Ramirez RA, Soulen M, Strosberg J, Sung A, Thawer A, Wei B, Xu B, Segelov E
J Thorac Oncol 2020 Oct;15(10):1577-1598. Epub 2020 Jul 11 doi: 10.1016/j.jtho.2020.06.021. PMID: 32663527
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article

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    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

    Consumer resources

    Reviews

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